Genular: Defining Cellular Identity and Function

Details for: Cd47

Gene ID: 16423

Symbol: Cd47

Ensembl ID: ENSMUSG00000055447

Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Associated with

Cell-cell communication
(R-MMU-1500931)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Extracellular matrix organization
(R-MMU-1474244)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Integrin cell surface interactions
(R-MMU-216083)
Neutrophil degranulation
(R-MMU-6798695)
Signal regulatory protein family interactions
(R-MMU-391160)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Atp export
(GO:1904669)
Cell-cell adhesion mediator activity
(GO:0098632)
Cell adhesion
(GO:0007155)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to interleukin-12
(GO:0071349)
Cellular response to type ii interferon
(GO:0071346)
Extracellular exosome
(GO:0070062)
Inflammatory response
(GO:0006954)
Membrane
(GO:0016020)
Monocyte aggregation
(GO:0070487)
Negative regulation of phagocytosis
(GO:0050765)
Opsonization
(GO:0008228)
Plasma membrane
(GO:0005886)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of monocyte extravasation
(GO:2000439)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of t cell activation
(GO:0050870)
Protein binding
(GO:0005515)
Protein binding involved in heterotypic cell-cell adhesion
(GO:0086080)
Regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060368)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of interleukin-10 production
(GO:0032653)
Regulation of interleukin-12 production
(GO:0032655)
Regulation of nitric oxide biosynthetic process
(GO:0045428)
Regulation of tumor necrosis factor production
(GO:0032680)
Regulation of type ii interferon production
(GO:0032649)
Response to bacterium
(GO:0009617)
Thrombospondin receptor activity
(GO:0070053)

Other Information

Proteins

Leukocyte surface antigen CD47

Genular Protein ID: 669588607

Symbol: CD47_MOUSE

Name: Leukocyte surface antigen CD47

UniProtKB Accession Codes:

Q61735 Q921Z2

Database IDs:

Citations:

PubMed ID: 7691831

Title: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding.

PubMed ID: 7691831

DOI: 10.1083/jcb.123.2.485

PubMed ID: 9504415

Title: Integrin-associated protein (IAP, also termed CD47) is involved in stroma-supported erythropoiesis.

PubMed ID: 9504415

DOI: 10.1093/oxfordjournals.jbchem.a021895

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10856220

Title: Role of CD47 as a marker of self on red blood cells.

PubMed ID: 10856220

DOI: 10.1126/science.288.5473.2051

PubMed ID: 15917238

Title: CD47 augments Fas/CD95-mediated apoptosis.

PubMed ID: 15917238

DOI: 10.1074/jbc.m500922200

PubMed ID: 18156939

Title: Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts.

PubMed ID: 18156939

DOI: 10.1097/sla.0b013e31815685dc

PubMed ID: 20610415

Title: Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation.

PubMed ID: 20610415

DOI: 10.1093/cvr/cvq218

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23591719

Title: Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors.

PubMed ID: 23591719

DOI: 10.1038/srep01673

PubMed ID: 27742621

Title: TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

PubMed ID: 27742621

DOI: 10.1093/cvr/cvw218

PubMed ID: 32679764

Title: CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.

PubMed ID: 32679764

DOI: 10.3390/cells9071695

Sequence Information:

Length: 303
Mass: 33098
Checksum: 87C0E6EF758FFF58
Sequence:

MWPLAAALLL GSCCCGSAQL LFSNVNSIEF TSCNETVVIP CIVRNVEAQS TEEMFVKWKL 
NKSYIFIYDG NKNSTTTDQN FTSAKISVSD LINGIASLKM DKRDAMVGNY TCEVTELSRE 
GKTVIELKNR TVSWFSPNEK ILIVIFPILA ILLFWGKFGI LTLKYKSSHT NKRIILLLVA 
GLVLTVIVVV GAILLIPGEK PVKNASGLGL IVISTGILIL LQYNVFMTAF GMTSFTIAIL 
ITQVLGYVLA LVGLCLCIMA CEPVHGPLLI SGLGIIALAE LLGLVYMKFV ASNQRTIQPP 
RNR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd47

Associated with

Other Information

Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding. PubMed ID: 7691831

Integrin-associated protein (IAP, also termed CD47) is involved in stroma-supported erythropoiesis. PubMed ID: 9504415

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of CD47 as a marker of self on red blood cells. PubMed ID: 10856220

CD47 augments Fas/CD95-mediated apoptosis. PubMed ID: 15917238

Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. PubMed ID: 18156939

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation. PubMed ID: 20610415

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors. PubMed ID: 23591719

TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. PubMed ID: 27742621

CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. PubMed ID: 32679764