Details for: Itk

Gene ID: 16428

Symbol: Itk

Ensembl ID: ENSMUSG00000020395

Description: IL2 inducible T cell kinase

Associated with

Other Information

Genular Protein ID: 2061883772

Symbol: ITK_MOUSE

Name: Tyrosine-protein kinase ITK/TSK

UniProtKB Accession Codes:

Q03526

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 4 CTD 1 ChEBI 12 ChiTaRS 1 DIP 1 DNASU 1 EC 2 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 4 GeneTree 1 Genevisible 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 12 PIR 1 PRINTS 3 PRO 1 PROSITE 7 PROSITE-ProRule 6 PaxDb 1 Pfam 5 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 3 SAM 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1280821

Title: itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

PubMed ID: 1280821

DOI: 10.1073/pnas.89.23.11194

PubMed ID: 8421704

Title: Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

PubMed ID: 8421704

DOI: 10.1073/pnas.90.2.669

PubMed ID: 8476425

Title: Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.

PubMed ID: 8476425

DOI: 10.1006/bbrc.1993.1404

PubMed ID: 8777721

Title: Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

PubMed ID: 8777721

DOI: 10.1016/1074-7613(95)90065-9

PubMed ID: 15662016

Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

PubMed ID: 15662016

DOI: 10.1126/science.1103336

PubMed ID: 19597499

Title: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.

PubMed ID: 19597499

DOI: 10.1038/ni.1766

PubMed ID: 8985255

Title: Regulatory intramolecular association in a tyrosine kinase of the Tec family.

PubMed ID: 8985255

DOI: 10.1038/385093a0

PubMed ID: 7524075

Title: CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

PubMed ID: 7524075

DOI: 10.1073/pnas.91.20.9347

PubMed ID: 8943565

Title: CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK.

PubMed ID: 8943565

DOI: 10.1093/intimm/8.11.1707

PubMed ID: 10570288

Title: Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.

PubMed ID: 10570288

PubMed ID: 10213685

Title: Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.

PubMed ID: 10213685

DOI: 10.1126/science.284.5414.638

PubMed ID: 16860760

Title: Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

PubMed ID: 16860760

DOI: 10.1016/j.immuni.2006.05.011

PubMed ID: 20237289

Title: Disrupting the intermolecular self-association of Itk enhances T cell signaling.

PubMed ID: 20237289

DOI: 10.4049/jimmunol.0901908

PubMed ID: 21036902

Title: Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.

PubMed ID: 21036902

DOI: 10.1074/jbc.m110.148205

PubMed ID: 23562159

Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.

PubMed ID: 23562159

DOI: 10.1016/j.immuni.2013.01.010

Sequence Information:

  • Length: 625
  • Mass: 72292
  • Checksum: F7A4A18A8A1AADDC
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 
KCVEIVKSDI SIPCHYKYPF QTLVYLQVVH DNYLLYVFAP DCESRQRWVL TLKEETRNNN 
SLVSKYHPNF WMDGRWRCCS QLEKPAVGCA PYDPSKNASK KPLPPTPEDN RRSFQEPEET 
LVIALYDYQT NDPQELALRC DEEYYLLDSS EIHWWRVQDK NGHEGYAPSS YLVEKSPNNL 
ETYEWYNKSI SRDKAEKLLL DTGKEGAFMV RDSRTPGTYT VSVFTKAIIS ENPCIKHYHI 
KETNDSPKRY YVAEKYVFDS IPLLIQYHQY NGGGLVTRLR YPVCSWRQKA PVTAGLRYGK 
WVIQPSELTF VQEIGSGQFG LVHLGYWLNK DKVAIKTIQE GAMSEEDFIE EAEVMMKLSH 
PKLVQLYGVC LEQAPICLVF EFMEHGCLSD YLRSQRGLFA AETLLGMCLD VCEGMAYLEK 
ACVIHRDLAA RNCLVGENQV IKVSDFGMTR FVLDDQYTSS TGTKFPVKWA SPEVFSFSRY 
SSKSDVWSFG VLMWEVFSEG KIPYENRSNS EVVEDISTGF RLYKPRLASC HVYQIMNHCW 
KEKPEDRPPF SQLLSQLAEI AEAGL

Genular Protein ID: 1356629314

Symbol: Q5STT8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5STT8

Database IDs:

AGR 1 ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 4 GeneTree 1 HOGENOM 1 InterPro 15 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 11 PROSITE-ProRule 4 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 5 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 619
  • Mass: 71574
  • Checksum: FF97AA30F8545B6B
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ RWVLTLKEET RNNNSLVSKY 
HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK NASKKPLPPT PEDNRRSFQE PEETLVIALY 
DYQTNDPQEL ALRCDEEYYL LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY 
NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIISENPCIK HYHIKETNDS 
PKRYYVAEKY VFDSIPLLIQ YHQYNGGGLV TRLRYPVCSW RQKAPVTAGL RYGKWVIQPS 
ELTFVQEIGS GQFGLVHLGY WLNKDKVAIK TIQEGAMSEE DFIEEAEVMM KLSHPKLVQL 
YGVCLEQAPI CLVFEFMEHG CLSDYLRSQR GLFAAETLLG MCLDVCEGMA YLEKACVIHR 
DLAARNCLVG ENQVIKVSDF GMTRFVLDDQ YTSSTGTKFP VKWASPEVFS FSRYSSKSDV 
WSFGVLMWEV FSEGKIPYEN RSNSEVVEDI STGFRLYKPR LASCHVYQIM NHCWKEKPED 
RPPFSQLLSQ LAEIAEAGL

Genular Protein ID: 4056828232

Symbol: A1A560_MOUSE

Name: N/A

UniProtKB Accession Codes:

A1A560

Database IDs:

AGR 1 ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 GO 7 Gene3D 4 InterPro 15 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 11 PROSITE-ProRule 4 Pfam 5 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 5 SUPFAM 4 UCSC 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 618
  • Mass: 71446
  • Checksum: 30E940B26E3B0268
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKRTL KGSIELSRIK 
CVEIVKSDIS IPCHYKYPFQ VVHDNYLLYV FAPDCESRQR WVLTLKEETR NNNSLVSKYH 
PNFWMDGRWR CCSQLEKPAV GCAPYDPSKN ASKKPLPPTP EDNRRSFQEP EETLVIALYD 
YQTNDPQELA LRCDEEYYLL DSSEIHWWRV QDKNGHEGYA PSSYLVEKSP NNLETYEWYN 
KSISRDKAEK LLLDTGKEGA FMVRDSRTPG TYTVSVFTKA IISENPCIKH YHIKETNDSP 
KRYYVAEKYV FDSIPLLIQY HQYNGGGLVT RLRYPVCSWR QKAPVTAGLR YGKWVIQPSE 
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAAETLLGM CLDVCEGMAY LEKACVIHRD 
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASCHVYQIMN HCWKEKPEDR 
PPFSQLLSQL AEIAEAGL

Genular Protein ID: 1944278288

Symbol: Q5STT7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5STT7

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 7 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 264
  • Mass: 31287
  • Checksum: A8C30A72892DC755
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ RWVLTLKEET RNNNSLVSKY 
HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK NASKKPLPPT PEDNRRSFQE PEETLVIALY 
DYQTNDPQEL ALRCDEEYYL LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY 
NKSISRDKAE KLLLDTVKKW TRIL

Genular Protein ID: 47589037

Symbol: Q3U5G1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U5G1

Database IDs:

AGR 1 ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 7 Gene3D 4 InterPro 15 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 11 PROSITE-ProRule 4 Pfam 5 RefSeq 4 Rhea 3 RuleBase 1 SAM 1 SMART 5 SUPFAM 4 UCSC 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 622
  • Mass: 71888
  • Checksum: 77BDD985078C354B
  • Sequence:
    • MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ RWVLTLKEKT RNNNSLVSKY 
HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK NASKKPLPPT PEDNRVSERS FQEPEETLVI 
ALYDYQTNDP QELALRCDEE YYLLDSSEIH WWRVQDKNGH EGYAPSSYLV EKSPNNLETY 
EWYNKSISRD KAEKLLLDTG KEGAFMVRDS RTPGTYTVSV FTKAIISENP CIKHYHIKET 
NDSPKRYYVA EKYVFDSIPL LIQYHQYNGG GLVTRLRYPV CSWRQKAPVT AGLRYGKWVI 
QPSELTFVQE IGSGQFGLVH LGYWLNKDKV AIKTIQEGAM SEEDFIEEAE VMMKLSHPKL 
VQLYGVCLEQ APICLVFEFM EHGCLSDYLR SQRGLFAAET LLGMCLDVCE GMAYLEKACV 
IHRDLAARNC LVGENQVIKV SDFGMTRFVL DDQYTSSTGT KFPVKWASPE VFSFSRYSSK 
SDVWSFGVLM WEVFSEGKIP YENRSNSEVV EDISTGFRLY KPRLASCHVY QIMNHCWKEK 
PEDRPPFSQL LSQLAEIAEA GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.