Genular: Defining Cellular Identity and Function

Details for: Itpr2

Gene ID: 16439

Symbol: Itpr2

Ensembl ID: ENSMUSG00000030287

Description: inositol 1,4,5-triphosphate receptor 2

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Cardiac conduction
(R-MMU-5576891)
Effects of pip2 hydrolysis
(R-MMU-114508)
Elevation of cytosolic ca2+ levels
(R-MMU-139853)
G alpha (q) signalling events
(R-MMU-416476)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Integration of energy metabolism
(R-MMU-163685)
Ion homeostasis
(R-MMU-5578775)
Metabolism
(R-MMU-1430728)
Muscle contraction
(R-MMU-397014)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet calcium homeostasis
(R-MMU-418360)
Platelet homeostasis
(R-MMU-418346)
Regulation of insulin secretion
(R-MMU-422356)
Signaling by gpcr
(R-MMU-372790)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Axon
(GO:0030424)
Calcium-release channel activity
(GO:0015278)
Calcium channel activity
(GO:0005262)
Calcium ion binding
(GO:0005509)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Cell cortex
(GO:0005938)
Cellular response to camp
(GO:0071320)
Cellular response to ethanol
(GO:0071361)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Inositol 1,4,5 trisphosphate binding
(GO:0070679)
Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
(GO:0005220)
Membrane
(GO:0016020)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nucleoplasm
(GO:0005654)
Phosphatidylinositol binding
(GO:0035091)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to hypoxia
(GO:0001666)
Sarcoplasmic reticulum
(GO:0016529)
Sarcoplasmic reticulum membrane
(GO:0033017)
Scaffold protein binding
(GO:0097110)
Secretory granule membrane
(GO:0030667)
Transmembrane transport
(GO:0055085)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Inositol 1,4,5-trisphosphate receptor type 2
Q8CED6_MOUSE

Genular Protein ID: 340476464

Symbol: ITPR2_MOUSE

Name: Inositol 1,4,5-trisphosphate receptor type 2

UniProtKB Accession Codes:

Q9Z329 B2KF91 P70226 Q5DWM3 Q5DWM5 Q61744 Q8R3B0

Database IDs:

Citations:

PubMed ID: 15632133

Title: Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

PubMed ID: 15632133

DOI: 10.1074/jbc.m413824200

PubMed ID: 9729462

Title: Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor.

PubMed ID: 9729462

DOI: 10.1042/bj3340559

PubMed ID: 20189985

Title: Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.

PubMed ID: 20189985

DOI: 10.1074/jbc.m109.096016

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8063813

Title: Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

PubMed ID: 8063813

DOI: 10.1016/s0021-9258(17)31861-6

PubMed ID: 9065779

Title: Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

PubMed ID: 9065779

DOI: 10.1042/bj3220575

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19608738

Title: Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937.

PubMed ID: 19608738

DOI: 10.1074/jbc.m109.010132

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 25329695

Title: Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.

PubMed ID: 25329695

DOI: 10.1172/jci70720

Sequence Information:

Length: 2701
Mass: 307475
Checksum: E7853104F0BD9B08
Sequence:

MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV 
CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV 
IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD 
KVVLMPVNAG QPLHASNVEL LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV 
RLFHAEQEKF LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI MYTLVSVPHG 
NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TTIPIDTEEE RPVMLKIGTC 
QTKEDKEAFA IVCVPLSEVR DLDFANDANK VLATTVKKLE NGSITQNERR FVTKLLEDLI 
FFVADVTNNG QDVLDVVITK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED 
LGDQRYAPYK YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE LICKFMLSPG 
NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAREGT 
KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR 
LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE 
YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 
SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV HPSKQASPGE 
QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF GDNNDNGDPS ASGTPDTLLP 
SALVPDIDEI AAQAETMFAG RKEKTPVQLD DEGGRTFLRV LIHLIMHDYA PLLSGALQLL 
FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD 
VGEGQAKGGE EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR 
NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP QNQVLLHKHL 
NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD 
GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLNMMC SERARGDESG PLAYHITLVE 
LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE 
IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST 
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA IPVDLDSQVN 
TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM 
MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE 
MLEKKDSFME EGSTLRRILL NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI 
SMSDIQCLLD KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ 
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM RVRDSSLHLR 
EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS AEEKSAEEVT MSPAITIMRP 
ILRFLQLLCE NHNRELQNFL RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINER 
NVALVNQTLE SLTEYCQGPC HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL 
KNNASKLLLA IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS 
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE IVRHDRTMEQ 
IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRNNPALF 
WFSRHISLWG SISFNLAVFI NLAVALFYPF GDDGDEGTLS PMFSVLLWVA VAICTSMLFF 
FSKPVGIRPF LVSVMLRSIY TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV 
ILDMAFLYHV AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME TCQKENCSPT 
IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY 
DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE 
EHIKSEHNMW HYLYFIVLVK VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD 
SEQNEIRNLQ EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP 
H

Genular Protein ID: 3874307777

Symbol: Q8CED6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CED6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 495
Mass: 56373
Checksum: B18ADE3A06BA1AFE
Sequence:

MKWQKKIRNN PALFWFSRHI SLWGSISFNL AVFINLAVAL FYPFGDDGDE GTLSPMFSVL 
LWVAVAICTS MLFFFSKPVG IRPFLVSVML RSIYTIGLGP TLILLGAANL CNKIVFLVSF 
VGNRGTFTRG YRAVILDMAF LYHVAYVLVC MLGLFVHEFF YSFLLFDLVY REETLLNVIK 
SVTRNGRSII LTAVLALILV YLFSIIGFLF LKDDFTMEVD RLKNRTPVTG NHGVPTMTLS 
SMMETCQKEN CSPTIPSSNT AVEEGEDGIE RTCDTLLMCI VTVLNQGLRN GGGVGDVLRR 
PSKDEPLFAA RVVYDLLFFF IVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG 
LERDKFDNKT VSFEEHIKSE HNMWHYLYFI VLVKVKDPTE YTGPESYVAQ MITEKNLDWF 
PRMRAMSLVS NEGDSEQNEI RNLQEKLEST MSLVKQLSGQ LAELKEQMTE QRKNKQRLGF 
LGSNTPHVNH HMPPH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itpr2

Associated with

Other Information

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. PubMed ID: 15632133

Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor. PubMed ID: 9729462

Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. PubMed ID: 20189985

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction. PubMed ID: 8063813

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin. PubMed ID: 9065779

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937. PubMed ID: 19608738

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Abolished InsP3R2 function inhibits sweat secretion in both humans and mice. PubMed ID: 25329695

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073