Genular: Defining Cellular Identity and Function

Details for: Itpr3

Gene ID: 16440

Symbol: Itpr3

Ensembl ID: ENSMUSG00000042644

Description: inositol 1,4,5-triphosphate receptor 3

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Cardiac conduction
(R-MMU-5576891)
Effects of pip2 hydrolysis
(R-MMU-114508)
Elevation of cytosolic ca2+ levels
(R-MMU-139853)
G alpha (q) signalling events
(R-MMU-416476)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Integration of energy metabolism
(R-MMU-163685)
Ion homeostasis
(R-MMU-5578775)
Metabolism
(R-MMU-1430728)
Muscle contraction
(R-MMU-397014)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet calcium homeostasis
(R-MMU-418360)
Platelet homeostasis
(R-MMU-418346)
Regulation of insulin secretion
(R-MMU-422356)
Sensory perception
(R-MMU-9709957)
Sensory perception of sweet, bitter, and umami (glutamate) taste
(R-MMU-9717207)
Sensory perception of taste
(R-MMU-9717189)
Signaling by gpcr
(R-MMU-372790)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Brush border
(GO:0005903)
Calcium-release channel activity
(GO:0015278)
Calcium channel activity
(GO:0005262)
Calcium ion binding
(GO:0005509)
Calcium ion homeostasis
(GO:0055074)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Cellular response to camp
(GO:0071320)
Cytoplasm
(GO:0005737)
Cytoplasmic side of endoplasmic reticulum membrane
(GO:0098554)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Inositol 1,3,4,5 tetrakisphosphate binding
(GO:0043533)
Inositol 1,4,5 trisphosphate binding
(GO:0070679)
Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
(GO:0005220)
Inositol hexakisphosphate binding
(GO:0000822)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Neuronal cell body
(GO:0043025)
Nuclear envelope
(GO:0005635)
Nuclear outer membrane
(GO:0005640)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol binding
(GO:0035091)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Presynapse
(GO:0098793)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to calcium ion
(GO:0051592)
Sarcoplasmic reticulum
(GO:0016529)
Secretory granule membrane
(GO:0030667)
Sensory perception of bitter taste
(GO:0050913)
Sensory perception of sweet taste
(GO:0050916)
Sensory perception of umami taste
(GO:0050917)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

Inositol 1,4,5-trisphosphate receptor type 3

Genular Protein ID: 3965506527

Symbol: ITPR3_MOUSE

Name: Inositol 1,4,5-trisphosphate receptor type 3

UniProtKB Accession Codes:

P70227 Q5DWM4 Q8CED5 Q91Z08

Database IDs:

Citations:

PubMed ID: 15632133

Title: Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

PubMed ID: 15632133

DOI: 10.1074/jbc.m413824200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1374893

Title: Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

PubMed ID: 1374893

DOI: 10.1073/pnas.89.10.4265

PubMed ID: 9065779

Title: Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

PubMed ID: 9065779

DOI: 10.1042/bj3220575

PubMed ID: 11149946

Title: Regulating ankyrin dynamics: roles of sigma-1 receptors.

PubMed ID: 11149946

DOI: 10.1073/pnas.98.2.491

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20071408

Title: Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells.

PubMed ID: 20071408

DOI: 10.1093/chemse/bjp097

PubMed ID: 20813840

Title: Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

PubMed ID: 20813840

DOI: 10.1074/jbc.m110.140129

PubMed ID: 21030605

Title: PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.

PubMed ID: 21030605

DOI: 10.1126/science.1189157

PubMed ID: 23650607

Title: Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes.

PubMed ID: 23650607

DOI: 10.1016/j.fob.2012.08.005

PubMed ID: 20843799

Title: Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.

PubMed ID: 20843799

DOI: 10.1074/jbc.m110.140160

Sequence Information:

Length: 2670
Mass: 304275
Checksum: 9B5BA808B195C58F
Sequence:

MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 
PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 
VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 
DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 
VRLFHAEQEK FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGLGAQGR TGRRNAGEKI KYRLVAVPHG 
NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNAPIDVEEE RPIRLMLGTC 
PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 
FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE 
LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE LICKCVLDPK 
NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN NEHHEKSVRQ LAQEARAGNA 
HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISKQLGVELL FLCMADEMLP FDLRASFCHL 
MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY 
LNNVVSEAVP FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 
MLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPAGVGVPEQ LDRSKFEDNE 
HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSST 
ATMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLL HLTMHDYPSL VSGALQLLFK 
HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEVE 
AGATKDKKER PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 
DAHKVMLDLL QIPYDKSDNK MLEILRYTHQ FLQKFCAGNP GNQALLHKHL QLFLTPGLLE 
AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM 
IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN 
VYTEIKCTSL LPLEDVVTVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL 
FENFTLDMAL VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ 
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA LLSSGGSCSA 
AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIM ALEERLKPLV QAELSVLVDM 
LHWPELLFPE GSEAYQRCES GGFLSKLIRH TKGLMESEEK LCVKVLRTLQ QMLLKKSKFG 
DRGNQLRKML LQNYLQNRKS GARGELTDPT GSGLDQDWSA IAATQCRLDK EGATKLVCDL 
ITSTKNEKIF QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET 
KSTVAVNMSD LGSQPREDRE PADPATKGRV SSFSMPSSSR YLLGLGLHRG HDMSERAQNN 
EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DIMCGSTTGG 
LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT ALILNDISPL 
CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN 
SEVSPREVGH NIYILALQLS RHNKQLQHLL KPVRRIQEEE AEGISSMLSL NNKQLSQMLK 
SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET KHRLFTTTEQ 
DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM TLWGSISFNL AVFINIIIAF 
FYPYVEGAST GVLGSPLISL LFWILICFSI AALFTKRYSV RPLIVALILR SIYYLGIGPT 
LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY 
SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR 
LPGNHSRASP LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEEPDST ERACDTLLMC 
IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA 
DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT 
DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTS 
QLNELKEQMT EQRKRRQRLG FVDVQNCMSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itpr3

Associated with

Other Information

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. PubMed ID: 15632133

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues. PubMed ID: 1374893

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin. PubMed ID: 9065779

Regulating ankyrin dynamics: roles of sigma-1 receptors. PubMed ID: 11149946

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells. PubMed ID: 20071408

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. PubMed ID: 20813840

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. PubMed ID: 21030605

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes. PubMed ID: 23650607

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating. PubMed ID: 20843799