Genular: Defining Cellular Identity and Function

Details for: Jak2

Gene ID: 16452

Symbol: Jak2

Ensembl ID: ENSMUSG00000024789

Description: Janus kinase 2

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cyclin d associated events in g1
(R-MMU-69231)
Cytokine signaling in immune system
(R-MMU-1280215)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-MMU-9027276)
Erythropoietin activates ras
(R-MMU-9027284)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G1 phase
(R-MMU-69236)
Growth hormone receptor signaling
(R-MMU-982772)
Hemostasis
(R-MMU-109582)
Ifng signaling activates mapks
(R-MMU-9732724)
Il-6-type cytokine receptor ligand interactions
(R-MMU-6788467)
Immune system
(R-MMU-168256)
Inactivation of csf3 (g-csf) signaling
(R-MMU-9705462)
Interferon gamma signaling
(R-MMU-877300)
Interferon signaling
(R-MMU-913531)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin-4 and interleukin-13 signaling
(R-MMU-6785807)
Interleukin-6 family signaling
(R-MMU-6783589)
Interleukin-6 signaling
(R-MMU-1059683)
Interleukin-12 family signaling
(R-MMU-447115)
Interleukin-12 signaling
(R-MMU-9020591)
Interleukin-20 family signaling
(R-MMU-8854691)
Interleukin-23 signaling
(R-MMU-9020933)
Interleukin-27 signaling
(R-MMU-9020956)
Interleukin-35 signalling
(R-MMU-8984722)
Interleukin receptor shc signaling
(R-MMU-912526)
Mapk1 (erk2) activation
(R-MMU-112411)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk3 (erk1) activation
(R-MMU-110056)
Mapk family signaling cascades
(R-MMU-5683057)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Prolactin receptor signaling
(R-MMU-1170546)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Raf/map kinase cascade
(R-MMU-5673001)
Raf activation
(R-MMU-5673000)
Regulation of ifng signaling
(R-MMU-877312)
Signaling by csf3 (g-csf)
(R-MMU-9674555)
Signaling by erythropoietin
(R-MMU-9006335)
Signaling by interleukins
(R-MMU-449147)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Acetylcholine receptor binding
(GO:0033130)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
Chromatin organization
(GO:0006325)
Cytokine-mediated signaling pathway
(GO:0019221)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth hormone receptor binding
(GO:0005131)
Heme binding
(GO:0020037)
Histone binding
(GO:0042393)
Histone h3y41 kinase activity
(GO:0035401)
Hormone-mediated signaling pathway
(GO:0009755)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Insulin receptor substrate binding
(GO:0043560)
Interleukin-12 receptor binding
(GO:0005143)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Microglial cell activation
(GO:0001774)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cell population proliferation
(GO:0008285)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Peptide hormone receptor binding
(GO:0051428)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphorylation
(GO:0016310)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of platelet activation
(GO:0010572)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor signaling pathway via jak-stat
(GO:0007259)
Response to oxidative stress
(GO:0006979)
Sh2 domain binding
(GO:0042169)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Transcription by rna polymerase ii
(GO:0006366)
Transferase activity
(GO:0016740)
Type 1 angiotensin receptor binding
(GO:0031702)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Janus kinase 2

Genular Protein ID: 2712519592

Symbol: JAK2_MOUSE

Name: Janus kinase 2

UniProtKB Accession Codes:

Q62120 G5E852 Q62124 Q7TQD0

Database IDs:

Citations:

PubMed ID: 8378315

Title: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

PubMed ID: 8378315

DOI: 10.1073/pnas.90.18.8429

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2482828

Title: The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.

PubMed ID: 2482828

DOI: 10.1016/0378-1119(89)90465-4

PubMed ID: 2466296

Title: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.

PubMed ID: 2466296

DOI: 10.1073/pnas.86.5.1603

PubMed ID: 8343951

Title: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.

PubMed ID: 8343951

DOI: 10.1016/0092-8674(93)90414-l

PubMed ID: 7775438

Title: The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.

PubMed ID: 7775438

DOI: 10.1074/jbc.270.23.13814

PubMed ID: 8702638

Title: An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells.

PubMed ID: 8702638

DOI: 10.1074/jbc.271.32.19483

PubMed ID: 9473212

Title: Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription.

PubMed ID: 9473212

PubMed ID: 9573010

Title: Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.

PubMed ID: 9573010

PubMed ID: 9590173

Title: Jak2 is essential for signaling through a variety of cytokine receptors.

PubMed ID: 9590173

DOI: 10.1016/s0092-8674(00)81167-8

PubMed ID: 9590174

Title: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.

PubMed ID: 9590174

DOI: 10.1016/s0092-8674(00)81168-x

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20098430

Title: The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

PubMed ID: 20098430

DOI: 10.1038/nm.2079

PubMed ID: 10842184

Title: Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.

PubMed ID: 10842184

DOI: 10.1074/jbc.m004238200

PubMed ID: 11779507

Title: The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

PubMed ID: 11779507

DOI: 10.1016/s1097-2765(01)00401-4

PubMed ID: 11923481

Title: Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers.

PubMed ID: 11923481

DOI: 10.1210/mend.16.4.0800

PubMed ID: 17024180

Title: Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2.

PubMed ID: 17024180

DOI: 10.1038/sj.emboj.7601365

PubMed ID: 17565041

Title: SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms.

PubMed ID: 17565041

DOI: 10.1210/me.2007-0111

PubMed ID: 20304997

Title: Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.

PubMed ID: 20304997

DOI: 10.1210/me.2009-0355

PubMed ID: 21726629

Title: Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation.

PubMed ID: 21726629

DOI: 10.1016/j.cellsig.2011.06.015

PubMed ID: 21368206

Title: Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses.

PubMed ID: 21368206

DOI: 10.1073/pnas.1011115108

PubMed ID: 21423214

Title: Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.

PubMed ID: 21423214

DOI: 10.1038/onc.2011.68

PubMed ID: 17208428

Title: Jak2: normal function and role in hematopoietic disorders.

PubMed ID: 17208428

DOI: 10.1016/j.gde.2006.12.009

PubMed ID: 16824542

Title: Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.

PubMed ID: 16824542

DOI: 10.1016/j.jmb.2006.05.070

Sequence Information:

Length: 1132
Mass: 130595
Checksum: 7BA35989B880D0A6
Sequence:

MGMACLTMTE MEATSTSPVH QNGDIPGSAN SVKQIEPVLQ VYLYHSLGQA EGEYLKFPSG 
EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH DILYRIRFYF 
PHWYCSGSSR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 
MAVLDMMRIA KEKDQTPLAV YNSVSYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 
SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR 
GKHKESETLT EQDVQLYCDF PDIIDVSIKQ ANQECSNESR IVTVHKQDGK VLEIELSSLK 
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT 
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSNLKDLLNC 
YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGISDV QISPTLQRHN NVNQMVFHKI 
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHKTEVLL KVLDKAHRNY SESFFEAASM 
MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA 
MHFLEEKSLI HGNVCAKNIL LIREEDRRTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL 
ANLINNCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 
ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE 
LLKSNGRLPR PEGCPDEIYV IMTECWNNNV SQRPSFRDLS LRVDQIRDSI AA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Jak2

Associated with

Other Information

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. PubMed ID: 8378315

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. PubMed ID: 2482828

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. PubMed ID: 2466296

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. PubMed ID: 8343951

The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. PubMed ID: 7775438

An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells. PubMed ID: 8702638

Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription. PubMed ID: 9473212

Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. PubMed ID: 9573010

Jak2 is essential for signaling through a variety of cytokine receptors. PubMed ID: 9590173

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. PubMed ID: 9590174

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. PubMed ID: 20098430

Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. PubMed ID: 10842184

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. PubMed ID: 11779507

Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. PubMed ID: 11923481

Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. PubMed ID: 17024180

SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. PubMed ID: 17565041

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. PubMed ID: 20304997

Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation. PubMed ID: 21726629

Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. PubMed ID: 21368206

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. PubMed ID: 21423214

Jak2: normal function and role in hematopoietic disorders. PubMed ID: 17208428

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. PubMed ID: 16824542