Genular: Defining Cellular Identity and Function

Details for: Jarid2

Gene ID: 16468

Symbol: Jarid2

Ensembl ID: ENSMUSG00000038518

Description: jumonji and AT-rich interaction domain containing 2

Associated with

Epigenetic regulation of gene expression
(R-MMU-212165)
Gene expression (transcription)
(R-MMU-74160)
Prc2 methylates histones and dna
(R-MMU-212300)
Cardiac muscle cell proliferation
(GO:0060038)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Dna binding
(GO:0003677)
Esc/e(z) complex
(GO:0035098)
Facultative heterochromatin formation
(GO:0140718)
Histone demethylase activity
(GO:0032452)
Histone h3k27 methyltransferase activity
(GO:0046976)
Histone methyltransferase complex
(GO:0035097)
Liver development
(GO:0001889)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Negative regulation of cardiac muscle cell proliferation
(GO:0060044)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein localization to pericentric heterochromatin
(GO:1902682)
Random inactivation of x chromosome
(GO:0060816)
Regulation of cell population proliferation
(GO:0042127)
Regulation of gene expression
(GO:0010468)
Spleen development
(GO:0048536)
Stem cell differentiation
(GO:0048863)
Thymus development
(GO:0048538)
Transcription factor binding
(GO:0008134)
Ubiquitin binding
(GO:0043130)
Ubiquitin modification-dependent histone binding
(GO:0061649)

Other Information

Proteins

Protein Jumonji

Genular Protein ID: 1085885203

Symbol: JARD2_MOUSE

Name: Protein Jumonji

UniProtKB Accession Codes:

Q62315 Q3TPU4 Q3UHS7 Q99LD1

Database IDs:

Citations:

PubMed ID: 7758946

Title: Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation.

PubMed ID: 7758946

DOI: 10.1101/gad.9.10.1211

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9376320

Title: Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice.

PubMed ID: 9376320

DOI: 10.1016/s0925-4773(97)00082-8

PubMed ID: 10446263

Title: jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background.

PubMed ID: 10446263

DOI: 10.1016/s0925-4773(99)00100-8

PubMed ID: 10913339

Title: Jumonji is a nuclear protein that participates in the negative regulation of cell growth.

PubMed ID: 10913339

DOI: 10.1006/bbrc.2000.3138

PubMed ID: 10807864

Title: Jumonji, a nuclear protein that is necessary for normal heart development.

PubMed ID: 10807864

DOI: 10.1161/01.res.86.9.932

PubMed ID: 12852854

Title: jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression.

PubMed ID: 12852854

DOI: 10.1016/s1534-5807(03)00189-8

PubMed ID: 12890668

Title: JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor.

PubMed ID: 12890668

DOI: 10.1074/jbc.m307386200

PubMed ID: 15542826

Title: Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.

PubMed ID: 15542826

DOI: 10.1128/mcb.24.23.10151-10160.2004

PubMed ID: 17521633

Title: Characterization of zinc finger protein 496 that interacts with Jumonji/JARID2.

PubMed ID: 17521633

DOI: 10.1016/j.febslet.2007.05.006

PubMed ID: 15870077

Title: Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein.

PubMed ID: 15870077

DOI: 10.1074/jbc.m414482200

PubMed ID: 20064376

Title: Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

PubMed ID: 20064376

DOI: 10.1016/j.cell.2009.12.003

PubMed ID: 20064375

Title: Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

PubMed ID: 20064375

DOI: 10.1016/j.cell.2009.12.002

PubMed ID: 19010785

Title: A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.

PubMed ID: 19010785

DOI: 10.1074/jbc.m804994200

PubMed ID: 20075857

Title: JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

PubMed ID: 20075857

DOI: 10.1038/nature08788

PubMed ID: 26523946

Title: Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.

PubMed ID: 26523946

DOI: 10.1002/stem.2243

PubMed ID: 19455710

Title: Solution structure of the AT-rich interaction domain of Jumonji/JARID2.

PubMed ID: 19455710

DOI: 10.1002/prot.22449

Sequence Information:

Length: 1234
Mass: 137445
Checksum: B56E172C5E5745B5
Sequence:

MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNAQKRQHGE GLAGSLKAVN 
GLLGNAQAKA LGPASEQSEN EKDDASQVSS TSNDVSSSDF EEGPSRKRPR LQAQRKFAQS 
QPNSPSTTPV KIVEPLLPPP ATQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ 
DEEDVEEEDD ETEDVKATTN NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK 
HRSKEATPGK EKHSEPRADS RREQASGAQP TAASAAASSA KGLAANHQPP PSHRSAQDLR 
KQVSKVNGVT RMSSLGAGTN SAKKIREVRP SPSKTVKYTA TVTKGTVTYT KAKRELVKET 
KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAASGLKAS SRLNPKSCTK 
EVGGRQLREG LRNSKRRLEE AQQVDKPQSP PKKMKGVAGN AEAPGKKASA ASGEKSLLNG 
HVKKEVPERS LERNRPKRAA AGKNMLGKQA HGKTEGTPCE NRSTSQPESS HKPHDPQGKP 
EKGSGKSGWA AMDEIPVLRP SAKEFHDPLI YIESVRAQVE KYGMCRVIPP PDWRPECKLN 
DEMRFVTQIQ HIHKLGRRWG PNVQRLACIK KHLRSQGITM DELPLIGGCE LDLACFFRLI 
NEMGGMQQVT DLKKWNKLAD MLRIPKTAQD RLAKLQEAYC QYLLSYDSLS PEEHRRLEKE 
VLMEKEILEK RKGPLEGHTE SDHHKFHSLP RFEPKNGLVH GVTPRNGFRS KLKEVGRAPL 
KTGRRRLFAQ EKEVVKEEEE DKGVLNDFHK CIYKGRSVSL TTFYRTARNI MNMCFSKEPA 
PAEIEQEYWR LVEEKDCHVA VHCGKVDTNT HGSGFPVGKS EPFSRHGWNL TVLPNNTGSI 
LRHLGAVPGV TIPWLNIGMV FSTSCWSRDQ NHLPYIDYLH TGADCIWYCI PAEEENKLED 
VVHTLLQGNG TPGLQMLESN VMISPEVLCK KGIKVHRTVQ QSGQFVVCFP GSFVSKVCCG 
YNVSETVHFA TTQWTSMGFE TAKEMKRRHI AKPFSMEKLL YQIAQAEAKK ENGPTLSTIS 
ALLDELRDTE LRQRRLLFEA GLHSSARYGS HDGNSTVADG KKKPRKWLQL ETSERRCQIC 
QHLCYLSMVV QENENVVFCL ECALRHVEKQ KSCRGLKLMY RYDEEQIISL VNQICGKVSG 
KHGGIENCLN KPTPKRGPRK RATVDVPPSR LPSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Jarid2

Associated with

Other Information

Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. PubMed ID: 7758946

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice. PubMed ID: 9376320

jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background. PubMed ID: 10446263

Jumonji is a nuclear protein that participates in the negative regulation of cell growth. PubMed ID: 10913339

Jumonji, a nuclear protein that is necessary for normal heart development. PubMed ID: 10807864

jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. PubMed ID: 12852854

JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. PubMed ID: 12890668

Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. PubMed ID: 15542826

Characterization of zinc finger protein 496 that interacts with Jumonji/JARID2. PubMed ID: 17521633

Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. PubMed ID: 15870077

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. PubMed ID: 20064376

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. PubMed ID: 20064375

A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. PubMed ID: 19010785

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. PubMed ID: 20075857

Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. PubMed ID: 26523946

Solution structure of the AT-rich interaction domain of Jumonji/JARID2. PubMed ID: 19455710