Genular: Defining Cellular Identity and Function

Details for: Ajuba

Gene ID: 16475

Symbol: Ajuba

Ensembl ID: ENSMUSG00000022178

Description: ajuba LIM protein

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to hypoxia
(R-MMU-1234174)
G2/m transition
(R-MMU-69275)
Mitotic g2-g2/m phases
(R-MMU-453274)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Actin filament binding
(GO:0051015)
Adherens junction
(GO:0005912)
Alpha-catenin binding
(GO:0045294)
Anchoring junction
(GO:0070161)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell cycle
(GO:0007049)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Focal adhesion
(GO:0005925)
Focal adhesion assembly
(GO:0048041)
Glycerophospholipid biosynthetic process
(GO:0046474)
Golgi apparatus
(GO:0005794)
Lamellipodium
(GO:0030027)
Lamellipodium assembly
(GO:0030032)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of kinase activity
(GO:0033673)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cellular biosynthetic process
(GO:0031328)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Protein binding
(GO:0005515)
Protein kinase activator activity
(GO:0030295)
Protein localization
(GO:0008104)
Regulation of cell migration
(GO:0030334)
Regulation of cellular response to hypoxia
(GO:1900037)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gtpase activity
(GO:0043087)
Regulatory ncrna-mediated gene silencing
(GO:0031047)
Response to hypoxia
(GO:0001666)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

LIM domain-containing protein ajuba

Genular Protein ID: 878576715

Symbol: AJUBA_MOUSE

Name: LIM domain-containing protein ajuba

UniProtKB Accession Codes:

Q91XC0 P97472

Database IDs:

Citations:

PubMed ID: 10330178

Title: Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.

PubMed ID: 10330178

DOI: 10.1128/mcb.19.6.4379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11029037

Title: Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions.

PubMed ID: 11029037

DOI: 10.1091/mbc.11.10.3299

PubMed ID: 15728191

Title: The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.

PubMed ID: 15728191

DOI: 10.1083/jcb.200406083

PubMed ID: 15870270

Title: The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.

PubMed ID: 15870270

DOI: 10.1128/mcb.25.10.3956-3966.2005

PubMed ID: 17909014

Title: The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling.

PubMed ID: 17909014

DOI: 10.1158/0008-5472.can-07-2987

PubMed ID: 18331720

Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

PubMed ID: 18331720

DOI: 10.1016/j.devcel.2008.01.005

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 547
Mass: 57920
Checksum: C326772AC1C155B2
Sequence:

MERLGEKASR LLEKLRLSDS GSAKFGRRKG EASRSGSDGT PGAGKGRLSG LGGPRKSGHR 
GANGGPGDEP LEPAREQGPL DAERNARGSF EAQRFEGSFP GGPPPTRALP LPLSSPPDFR 
LETTAPALSP RSSFASSSAS DASKPSSPRG SLLLDGAGAS GAGGSRPCSN RTSGISMGYD 
QRHGSPLPAG PCLFGLPLTT APAGYPGGAP SAYPELHAAL DRLCAHRSVG FGCQESRHSY 
PPALGSPGAL TGAVVGTAGP LERRGAQPGR HSVTGYGDCA AGARYQDELT ALLRLTVATG 
GREAGARGEP SGIEPSGLEE SPGPFVPEAS RSRIREPEAR EDYFGTCIKC NKGIYGQSNA 
CQALDSLYHT QCFVCCSCGR TLRCKAFYSV NGSVYCEEDY LFSGFQEAAE KCCVCGHLIL 
EKILQAMGKS YHPGCFRCIV CNKCLDGVPF TVDFSNQVYC VTDYHKNYAP KCAACGQPIL 
PSEGCEDIVR VISMDRDYHF ECYHCEDCRM QLSDEEGCCC FPLDGHLLCH GCHMQRLSAR 
QPSTNYI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ajuba

Associated with

Other Information

Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. PubMed ID: 10330178

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. PubMed ID: 11029037

The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. PubMed ID: 15728191

The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. PubMed ID: 15870270

The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. PubMed ID: 17909014

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. PubMed ID: 18331720

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079