Genular: Defining Cellular Identity and Function

Details for: Jun

Gene ID: 16476

Symbol: Jun

Ensembl ID: ENSMUSG00000052684

Description: jun proto-oncogene

Associated with

Activation of the ap-1 family of transcription factors
(R-MMU-450341)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated mapk activation
(R-MMU-2871796)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-MMU-450282)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Oxidative stress induced senescence
(R-MMU-2559580)
Signaling by interleukins
(R-MMU-449147)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Axon regeneration
(GO:0031103)
Camp response element binding
(GO:0035497)
Cell population proliferation
(GO:0008283)
Cellular response to reactive oxygen species
(GO:0034614)
Chromatin binding
(GO:0003682)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
General transcription initiation factor binding
(GO:0140296)
Gtpase activator activity
(GO:0005096)
Hmg box domain binding
(GO:0071837)
Identical protein binding
(GO:0042802)
Leading edge cell differentiation
(GO:0035026)
Learning
(GO:0007612)
Liver development
(GO:0001889)
Microglial cell activation
(GO:0001774)
Monocyte differentiation
(GO:0030224)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein autophosphorylation
(GO:0031953)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Release from viral latency
(GO:0019046)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to muscle stretch
(GO:0035994)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor binding
(GO:0008134)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

AH119

Genular Protein ID: 1405492187

Symbol: JUN_MOUSE

Name: AH119

UniProtKB Accession Codes:

P05627

Database IDs:

Citations:

PubMed ID: 3136397

Title: Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts.

PubMed ID: 3136397

DOI: 10.1038/334535a0

PubMed ID: 2457172

Title: Induction of proto-oncogene JUN/AP-1 by serum and TPA.

PubMed ID: 2457172

DOI: 10.1038/334629a0

PubMed ID: 3186736

Title: Induction of protooncogene c-jun by serum growth factors.

PubMed ID: 3186736

DOI: 10.1073/pnas.85.22.8464

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2498083

Title: The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

PubMed ID: 2498083

DOI: 10.1002/j.1460-2075.1989.tb03441.x

PubMed ID: 9447996

Title: Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.

PubMed ID: 9447996

DOI: 10.1128/mcb.18.2.989

PubMed ID: 11397794

Title: Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.

PubMed ID: 11397794

DOI: 10.1074/jbc.m101522200

PubMed ID: 11704680

Title: Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors.

PubMed ID: 11704680

DOI: 10.1074/jbc.m110417200

PubMed ID: 14707112

Title: Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.

PubMed ID: 14707112

DOI: 10.1084/jem.20030421

PubMed ID: 17210646

Title: Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.

PubMed ID: 17210646

DOI: 10.1128/mcb.02253-06

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20852630

Title: Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

PubMed ID: 20852630

DOI: 10.1038/ncb2098

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 27458189

Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.

PubMed ID: 27458189

DOI: 10.15252/embj.201593070

PubMed ID: 29272704

Title: AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.

PubMed ID: 29272704

DOI: 10.1016/j.molcel.2017.11.026

Sequence Information:

Length: 334
Mass: 35944
Checksum: 2BE0E4025B8B1CA3
Sequence:

MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 
LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA 
LSSGGGAPSY GAAGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG 
ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST 
ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Jun

Associated with

Other Information

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts. PubMed ID: 3136397

Induction of proto-oncogene JUN/AP-1 by serum and TPA. PubMed ID: 2457172

Induction of protooncogene c-jun by serum growth factors. PubMed ID: 3186736

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. PubMed ID: 2498083

Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb. PubMed ID: 9447996

Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. PubMed ID: 11397794

Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. PubMed ID: 11704680

Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. PubMed ID: 14707112

Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. PubMed ID: 17210646

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. PubMed ID: 20852630

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. PubMed ID: 27458189

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. PubMed ID: 29272704