Genular: Defining Cellular Identity and Function

Details for: Jup

Gene ID: 16480

Symbol: Jup

Ensembl ID: ENSMUSG00000001552

Description: junction plakoglobin

Associated with

Adherens junctions interactions
(R-MMU-418990)
Cell-cell communication
(R-MMU-1500931)
Cell-cell junction organization
(R-MMU-421270)
Cell junction organization
(R-MMU-446728)
Developmental biology
(R-MMU-1266738)
Formation of the cornified envelope
(R-MMU-6809371)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Keratinization
(R-MMU-6805567)
Neutrophil degranulation
(R-MMU-6798695)
Regulation of cdh11 expression and function
(R-MMU-9759475)
Regulation of cdh11 function
(R-MMU-9762292)
Regulation of expression and function of type ii classical cadherins
(R-MMU-9764260)
Regulation of homotypic cell-cell adhesion
(R-MMU-9759476)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rhoc gtpase cycle
(R-MMU-9013106)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Rhoq gtpase cycle
(R-MMU-9013406)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Actin cytoskeleton
(GO:0015629)
Adherens junction
(GO:0005912)
Alpha-catenin binding
(GO:0045294)
Anchoring junction
(GO:0070161)
Apicolateral plasma membrane
(GO:0016327)
Bundle of his cell-purkinje myocyte adhesion involved in cell communication
(GO:0086073)
Cadherin binding
(GO:0045296)
Canonical wnt signaling pathway
(GO:0060070)
Catenin complex
(GO:0016342)
Cell-cell adhesion
(GO:0098609)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell adhesion molecule binding
(GO:0050839)
Cell migration
(GO:0016477)
Cellular response to indole-3-methanol
(GO:0071681)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoskeletal protein-membrane anchor activity
(GO:0106006)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Desmosome
(GO:0030057)
Desmosome assembly
(GO:0002159)
Detection of mechanical stimulus
(GO:0050982)
Dna-binding transcription factor binding
(GO:0140297)
Fascia adherens
(GO:0005916)
Gamma-catenin-tcf7l2 complex
(GO:0071665)
Intercalated disc
(GO:0014704)
Intermediate filament
(GO:0005882)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to plasma membrane
(GO:0072659)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of cell population proliferation
(GO:0042127)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of ventricular cardiac muscle cell action potential
(GO:0098911)
Skin development
(GO:0043588)
Transcription coactivator activity
(GO:0003713)
Z disc
(GO:0030018)

Other Information

Proteins

Junction plakoglobin

Genular Protein ID: 3694552016

Symbol: PLAK_MOUSE

Name: Junction plakoglobin

UniProtKB Accession Codes:

Q02257 Q8CGD3

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1509266

Title: Plakoglobin and beta-catenin: distinct but closely related.

PubMed ID: 1509266

DOI: 10.1126/science.257.5073.1142-a

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 16325582

Title: Deconstructing the cadherin-catenin-actin complex.

PubMed ID: 16325582

DOI: 10.1016/j.cell.2005.09.020

PubMed ID: 19015309

Title: VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.

PubMed ID: 19015309

DOI: 10.1084/jem.20080406

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 745
Mass: 81801
Checksum: 9609619D94052FC5
Sequence:

MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GIMDEDDACG RQYTLKKTTT 
YTQGVPQNQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQT TNLQRLAEPS 
QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM 
GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE 
SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH 
LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC 
NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY 
GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR 
HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY 
RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT YRPMYSSDVP LDPLDMHMDL 
DGDYPMDTYS DGLRPPYPTA DHMLA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Jup

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Plakoglobin and beta-catenin: distinct but closely related. PubMed ID: 1509266

Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. PubMed ID: 7982500

Deconstructing the cadherin-catenin-actin complex. PubMed ID: 16325582

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. PubMed ID: 19015309

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079