Details for: Kcna2

Gene ID: 16490

Symbol: Kcna2

Ensembl ID: ENSMUSG00000040724

Description: potassium voltage-gated channel, shaker-related subfamily, member 2

Associated with

Other Information

Genular Protein ID: 2897363344

Symbol: KCNA2_MOUSE

Name: Potassium voltage-gated channel subfamily A member 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2305265

Title: A family of three mouse potassium channel genes with intronless coding regions.

PubMed ID: 2305265

DOI: 10.1126/science.2305265

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1691985

Title: Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction.

PubMed ID: 1691985

DOI: 10.1016/0014-5793(90)80719-y

PubMed ID: 8361541

Title: Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons.

PubMed ID: 8361541

DOI: 10.1038/365075a0

PubMed ID: 8046438

Title: Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain.

PubMed ID: 8046438

DOI: 10.1523/jneurosci.14-08-04588.1994

PubMed ID: 9635436

Title: The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.

PubMed ID: 9635436

DOI: 10.1016/s0092-8674(00)81212-x

PubMed ID: 9852577

Title: Heteromultimeric delayed-rectifier K+ channels in Schwann cells: developmental expression and role in cell proliferation.

PubMed ID: 9852577

DOI: 10.1523/jneurosci.18-24-10398.1998

PubMed ID: 12527813

Title: Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels.

PubMed ID: 12527813

DOI: 10.1124/mol.63.2.409

PubMed ID: 17925011

Title: Sleep in Kcna2 knockout mice.

PubMed ID: 17925011

DOI: 10.1186/1741-7007-5-42

PubMed ID: 17634333

Title: Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons.

PubMed ID: 17634333

DOI: 10.1152/jn.00640.2006

PubMed ID: 17917103

Title: Ionic channel function in action potential generation: current perspective.

PubMed ID: 17917103

DOI: 10.1007/s12035-007-8001-0

PubMed ID: 18509034

Title: Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.

PubMed ID: 18509034

DOI: 10.1523/jneurosci.4431-07.2008

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 18760366

Title: Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes.

PubMed ID: 18760366

DOI: 10.1016/j.mcn.2008.07.025

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20696761

Title: A new Kv1.2 channelopathy underlying cerebellar ataxia.

PubMed ID: 20696761

DOI: 10.1074/jbc.m110.153676

PubMed ID: 21233214

Title: Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.

PubMed ID: 21233214

DOI: 10.1074/jbc.m110.153262

PubMed ID: 22649228

Title: Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.

PubMed ID: 22649228

DOI: 10.1523/jneurosci.0719-12.2012

PubMed ID: 23332758

Title: Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.

PubMed ID: 23332758

DOI: 10.1016/j.cell.2012.12.004

PubMed ID: 23864368

Title: Association of the Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses.

PubMed ID: 23864368

DOI: 10.1152/jn.00290.2013

PubMed ID: 23981714

Title: Activity-dependent downregulation of D-type K+ channel subunit Kv1.2 in rat hippocampal CA3 pyramidal neurons.

PubMed ID: 23981714

DOI: 10.1113/jphysiol.2013.259002

PubMed ID: 25378149

Title: Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons.

PubMed ID: 25378149

DOI: 10.1523/jneurosci.3369-14.2014

PubMed ID: 26269648

Title: Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.

PubMed ID: 26269648

DOI: 10.1523/jneurosci.1346-15.2015

Sequence Information:

  • Length: 499
  • Mass: 56701
  • Checksum: A8FEA6F3F59AF42A
  • Sequence:
  • MTVATGDPVD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG 
    DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE 
    EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF 
    CLETLPIFRD ENEDMHGGGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR 
    FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR 
    VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERDSQFPS 
    IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE 
    TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA 
    NCTLANTNYV NITKMLTDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.