Genular: Defining Cellular Identity and Function

Details for: Kcna5

Gene ID: 16493

Symbol: Kcna5

Ensembl ID: ENSMUSG00000045534

Description: potassium voltage-gated channel, shaker-related subfamily, member 5

Associated with

Cardiac conduction
(R-MMU-5576891)
Muscle contraction
(R-MMU-397014)
Neuronal system
(R-MMU-112316)
Phase 3 - rapid repolarisation
(R-MMU-5576890)
Potassium channels
(R-MMU-1296071)
Voltage gated potassium channels
(R-MMU-1296072)
Alpha-actinin binding
(GO:0051393)
Atrial cardiac muscle cell action potential
(GO:0086014)
Cell surface
(GO:0009986)
Delayed rectifier potassium channel activity
(GO:0005251)
Intercalated disc
(GO:0014704)
Intracellular canaliculus
(GO:0046691)
Membrane
(GO:0016020)
Membrane hyperpolarization
(GO:0060081)
Membrane raft
(GO:0045121)
Membrane repolarization during atrial cardiac muscle cell action potential
(GO:0098914)
Membrane repolarization during bundle of his cell action potential
(GO:0086050)
Membrane repolarization during sa node cell action potential
(GO:0086052)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion channel complex
(GO:0034702)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of cytosolic calcium ion concentration
(GO:0051481)
Notch signaling pathway
(GO:0007219)
Outward rectifier potassium channel activity
(GO:0015271)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of myoblast proliferation
(GO:2000288)
Potassium channel activity
(GO:0005267)
Potassium channel complex
(GO:0034705)
Potassium ion export across plasma membrane
(GO:0097623)
Potassium ion homeostasis
(GO:0055075)
Potassium ion transmembrane transport
(GO:0071805)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Protein complex oligomerization
(GO:0051259)
Protein homooligomerization
(GO:0051260)
Protein kinase binding
(GO:0019901)
Regulation of atrial cardiac muscle cell membrane repolarization
(GO:0060372)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of membrane potential
(GO:0042391)
Regulation of potassium ion transport
(GO:0043266)
Regulation of vasoconstriction
(GO:0019229)
Scaffold protein binding
(GO:0097110)
Signaling receptor binding
(GO:0005102)
Transmembrane transport
(GO:0055085)
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
(GO:0086089)
Voltage-gated potassium channel activity involved in bundle of his cell action potential repolarization
(GO:0086087)
Voltage-gated potassium channel activity involved in sa node cell action potential repolarization
(GO:0086090)
Voltage-gated potassium channel complex
(GO:0008076)
Z disc
(GO:0030018)

Other Information

Proteins

Potassium voltage-gated channel subfamily A member 5

Genular Protein ID: 1065452453

Symbol: KCNA5_MOUSE

Name: Potassium voltage-gated channel subfamily A member 5

UniProtKB Accession Codes:

Q61762 Q9Z1R6

Database IDs:

Citations:

PubMed ID: 8226976

Title: Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel.

PubMed ID: 8226976

DOI: 10.1016/s0021-9258(20)80523-7

PubMed ID: 11349004

Title: Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation.

PubMed ID: 11349004

DOI: 10.1161/hh0901.090929

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 602
Mass: 66580
Checksum: 02926E85DC022DDA
Sequence:

MEISLVPMEN GSAMTLRGGG EAGASCVQSP RGECGCPPTA GLNNQSKETS PRRRATHEDA 
GQGGRPLPPM PQELPQPRRP SAEDEEGEGD PGLGTVEEDQ APQDSGSLHH QRVLINISGL 
RFETQLGTLA QFPNTLLGDP VKRLRYFDPL RNEYFFDRNR PSFDGILYYY QSGGRLRRPV 
NVSLDVFADE IRFYQLGDEA MERFREDEGF IKEEEKPLPR NEFQRQVWLI FEYPESSGSA 
RAIAIVSVLV ILISIITFCL ETLPEFRDER ELLRHPPVPP QPPAPAPGAN GSGSGVLSSG 
PTVAPLLPRT LADPFFIVET TCVIWFTFEL LVRFFACPSK AEFSRNIMNI IDIVAIFPYF 
ITLGTELAEQ QPGGGGQNGQ QAMSLAILRV IRLVRVFRIF KLSRHSKGLQ ILGKTLQASM 
RELGLLIFFL FIGVILFSSA VYFAEADNQG SHFSSIPDAF WWAVVTMTTV GYGDMRPITV 
GGKIVGSLCA IAGVLTIALP VPVIVSNFNY FYHRETDHEE QAALKEEQGI QRRESGLDTG 
GQRKVSCSKA SFCKTGGPLE STDSIRRGSC PLEKCHLKAK SNVDLRRSLY ALCLDTSRET 
DL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kcna5

Associated with

Other Information

Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel. PubMed ID: 8226976

Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation. PubMed ID: 11349004

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Database document:

PubMed ID: 8226976

PubMed ID: 11349004

PubMed ID: 16141072

PubMed ID: 15489334