Details for: AEBP1

Gene ID: 165

Symbol: AEBP1

Ensembl ID: ENSG00000106624

Description: AE binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.67
    Marker Score: 5051
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.05
    Marker Score: 103856
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.98
    Marker Score: 7811
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.73
    Marker Score: 708
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.37
    Marker Score: 987
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.21
    Marker Score: 509
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.14
    Marker Score: 1222
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.13
    Marker Score: 1818
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.11
    Marker Score: 9083
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.97
    Marker Score: 442
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.95
    Marker Score: 486
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.94
    Marker Score: 486
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.92
    Marker Score: 543
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.85
    Marker Score: 525
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.81
    Marker Score: 1285
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.75
    Marker Score: 514
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.74
    Marker Score: 1657
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.74
    Marker Score: 2085
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.72
    Marker Score: 3241
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.66
    Marker Score: 18731
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.66
    Marker Score: 820
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.59
    Marker Score: 1540
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.58
    Marker Score: 3042
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.57
    Marker Score: 991
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.56
    Marker Score: 501
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.54
    Marker Score: 7573.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.51
    Marker Score: 995
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.46
    Marker Score: 9521
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.41
    Marker Score: 349
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.38
    Marker Score: 911
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.38
    Marker Score: 1803
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.37
    Marker Score: 981
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.34
    Marker Score: 1649
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.28
    Marker Score: 3483.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.26
    Marker Score: 543
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.17
    Marker Score: 299
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.17
    Marker Score: 308
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.16
    Marker Score: 11793
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.16
    Marker Score: 469
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.13
    Marker Score: 3069
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16755
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.03
    Marker Score: 574
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71776
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48001
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.99
    Marker Score: 654
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.99
    Marker Score: 1048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.97
    Marker Score: 4052.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.96
    Marker Score: 1483
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.96
    Marker Score: 245
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.93
    Marker Score: 542
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5228
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1831
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1543
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.87
    Marker Score: 473
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5269
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.86
    Marker Score: 995
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.84
    Marker Score: 477
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.83
    Marker Score: 303
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.83
    Marker Score: 314
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 387
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.81
    Marker Score: 17287
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.8
    Marker Score: 948
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4820
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.79
    Marker Score: 829
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.78
    Marker Score: 10342
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1234
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.74
    Marker Score: 750
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.74
    Marker Score: 221
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.74
    Marker Score: 792
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556.5
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.71
    Marker Score: 201
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 422
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.7
    Marker Score: 604
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.69
    Marker Score: 170
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.69
    Marker Score: 1622.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.68
    Marker Score: 965.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.67
    Marker Score: 166
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.65
    Marker Score: 1349
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.64
    Marker Score: 229
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.64
    Marker Score: 6455.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.64
    Marker Score: 1272
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 676
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.63
    Marker Score: 287
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.62
    Marker Score: 701
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.62
    Marker Score: 150
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.61
    Marker Score: 386
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.6
    Marker Score: 443
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.59
    Marker Score: 205
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 394
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.58
    Marker Score: 281
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.56
    Marker Score: 979
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 370

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Other Information

**Key characteristics:** * AEBP1 is a secreted protein that is expressed in high levels in the skin, lung, and mammary gland. * The protein is a type I transmembrane protein that has a molecular weight of approximately 120 kDa. * AEBP1 is a dimer of two identical subunits that are held together by a disulfide bond. * The protein is a transcriptional repressor that binds to DNA sequences that are involved in the regulation of collagen fibril assembly. * AEBP1 is also a regulator of the expression of other genes that are involved in collagen fibril assembly. **Pathways and functions:** * AEBP1 binds to collagen type I and helps to promote its assembly into collagen fibrils. * The protein also binds to other extracellular matrix proteins, such as fibronectin and elastin, and helps to regulate their interactions with collagen. * AEBP1 is involved in the formation of the skin barrier, the basement membrane, and the extracellular matrix. * The protein is also involved in the regulation of wound healing and tissue regeneration. **Clinical significance:** Mutations in the AEBP1 gene have been linked to a number of human diseases, including psoriasis, rheumatoid arthritis, and fibrotic diseases. These diseases are characterized by the deposition of collagen in tissues, which can lead to tissue damage and dysfunction. AEBP1 is a potential target for the treatment of these diseases.

Genular Protein ID: 2598183619

Symbol: AEBP1_HUMAN

Name: Adipocyte enhancer-binding protein 1

UniProtKB Accession Codes:

Q8IUX7 Q14113 Q59ER7 Q6ZSC7 Q7KZ79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9624159

Title: Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.

PubMed ID: 9624159

DOI: 10.1074/jbc.273.25.15654

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8920928

Title: A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line.

PubMed ID: 8920928

DOI: 10.1006/bbrc.1996.1675

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27023906

Title: Expanding the clinical and genetic heterogeneity of hereditary disorders of connective tissue.

PubMed ID: 27023906

DOI: 10.1007/s00439-016-1660-z

PubMed ID: 29606302

Title: Bi-allelic alterations in AEBP1 lead to defective collagen assembly and connective tissue structure resulting in a variant of Ehlers-Danlos syndrome.

PubMed ID: 29606302

DOI: 10.1016/j.ajhg.2018.02.018

Sequence Information:

  • Length: 1158
  • Mass: 130929
  • Checksum: 1D7F4A20451646AE
  • Sequence:
    • MAAVRGAPLL SCLLALLALC PGGRPQTVLT DDEIEEFLEG FLSELEPEPR EDDVEAPPPP 
EPTPRVRKAQ AGGKPGKRPG TAAEVPPEKT KDKGKKGKKD KGPKVPKESL EGSPRPPKKG 
KEKPPKATKK PKEKPPKATK KPKEKPPKAT KKPKEKPPKA TKKPPSGKRP PILAPSETLE 
WPLPPPPSPG PEELPQEGGA PLSNNWQNPG EETHVEAREH QPEPEEETEQ PTLDYNDQIE 
REDYEDFEYI RRQKQPRPPP SRRRRPERVW PEPPEEKAPA PAPEERIEPP VKPLLPPLPP 
DYGDGYVIPN YDDMDYYFGP PPPQKPDAER QTDEEKEELK KPKKEDSSPK EETDKWAVEK 
GKDHKEPRKG EELEEEWTPT EKVKCPPIGM ESHRIEDNQI RASSMLRHGL GAQRGRLNMQ 
TGATEDDYYD GAWCAEDDAR TQWIEVDTRR TTRFTGVITQ GRDSSIHDDF VTTFFVGFSN 
DSQTWVMYTN GYEEMTFHGN VDKDTPVLSE LPEPVVARFI RIYPLTWNGS LCMRLEVLGC 
SVAPVYSYYA QNEVVATDDL DFRHHSYKDM RQLMKVVNEE CPTITRTYSL GKSSRGLKIY 
AMEISDNPGE HELGEPEFRY TAGIHGNEVL GRELLLLLMQ YLCREYRDGN PRVRSLVQDT 
RIHLVPSLNP DGYEVAAQMG SEFGNWALGL WTEEGFDIFE DFPDLNSVLW GAEERKWVPY 
RVPNNNLPIP ERYLSPDATV STEVRAIIAW MEKNPFVLGA NLNGGERLVS YPYDMARTPT 
QEQLLAAAMA AARGEDEDEV SEAQETPDHA IFRWLAISFA SAHLTLTEPY RGGCQAQDYT 
GGMGIVNGAK WNPRTGTIND FSYLHTNCLE LSFYLGCDKF PHESELPREW ENNKEALLTF 
MEQVHRGIKG VVTDEQGIPI ANATISVSGI NHGVKTASGG DYWRILNPGE YRVTAHAEGY 
TPSAKTCNVD YDIGATQCNF ILARSNWKRI REIMAMNGNR PIPHIDPSRP MTPQQRRLQQ 
RRLQHRLRLR AQMRLRRLNA TTTLGPHTVP PTLPPAPATT LSTTIEPWGL IPPTTAGWEE 
SETETYTEVV TEFGTEVEPE FGTKVEPEFE TQLEPEFETQ LEPEFEEEEE EEKEEEIATG 
QAFPFTTVET YTVNFGDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.