Details for: AEBP1

Gene ID: 165

Symbol: AEBP1

Ensembl ID: ENSG00000106624

Description: AE binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.9873
    Cell Significance Index: -20.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.7523
    Cell Significance Index: -19.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.7476
    Cell Significance Index: -19.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 19.1034
    Cell Significance Index: 306.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6835
    Cell Significance Index: -20.5700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.6017
    Cell Significance Index: 32.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.2057
    Cell Significance Index: 149.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1900
    Cell Significance Index: -20.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.7432
    Cell Significance Index: 43.5200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.6141
    Cell Significance Index: 12.0700
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.3632
    Cell Significance Index: 13.5500
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.2596
    Cell Significance Index: 14.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0973
    Cell Significance Index: 26.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8898
    Cell Significance Index: 259.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4275
    Cell Significance Index: 27.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4239
    Cell Significance Index: 182.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3017
    Cell Significance Index: 83.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8642
    Cell Significance Index: 18.0900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8421
    Cell Significance Index: 5.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6560
    Cell Significance Index: 5.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5919
    Cell Significance Index: 10.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4345
    Cell Significance Index: 63.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4138
    Cell Significance Index: 48.2200
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.3941
    Cell Significance Index: 0.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3813
    Cell Significance Index: 19.2700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3205
    Cell Significance Index: 6.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0918
    Cell Significance Index: 2.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0906
    Cell Significance Index: 3.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0804
    Cell Significance Index: 151.3800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0708
    Cell Significance Index: 0.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0705
    Cell Significance Index: 1.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0510
    Cell Significance Index: 22.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0443
    Cell Significance Index: 30.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0336
    Cell Significance Index: 6.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0213
    Cell Significance Index: 0.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0024
    Cell Significance Index: -0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0041
    Cell Significance Index: -0.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0115
    Cell Significance Index: -3.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0143
    Cell Significance Index: -10.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0154
    Cell Significance Index: -2.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0195
    Cell Significance Index: -6.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0200
    Cell Significance Index: -12.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0251
    Cell Significance Index: -19.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0265
    Cell Significance Index: -14.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0287
    Cell Significance Index: -16.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0301
    Cell Significance Index: -13.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0585
    Cell Significance Index: -12.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0683
    Cell Significance Index: -11.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0898
    Cell Significance Index: -5.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0908
    Cell Significance Index: -11.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0966
    Cell Significance Index: -19.3900
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1018
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1049
    Cell Significance Index: -1.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1069
    Cell Significance Index: -13.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1084
    Cell Significance Index: -11.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1122
    Cell Significance Index: -12.8100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1369
    Cell Significance Index: -1.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1403
    Cell Significance Index: -16.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1754
    Cell Significance Index: -18.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1796
    Cell Significance Index: -12.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1804
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1808
    Cell Significance Index: -20.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2097
    Cell Significance Index: -15.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2121
    Cell Significance Index: -16.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2167
    Cell Significance Index: -17.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2340
    Cell Significance Index: -14.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2455
    Cell Significance Index: -12.8900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.2736
    Cell Significance Index: -3.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2787
    Cell Significance Index: -7.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2939
    Cell Significance Index: -4.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2965
    Cell Significance Index: -19.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3117
    Cell Significance Index: -19.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3156
    Cell Significance Index: -7.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3170
    Cell Significance Index: -19.9800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3292
    Cell Significance Index: -1.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3520
    Cell Significance Index: -16.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3615
    Cell Significance Index: -6.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3877
    Cell Significance Index: -20.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4172
    Cell Significance Index: -11.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4244
    Cell Significance Index: -10.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4296
    Cell Significance Index: -3.4300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4376
    Cell Significance Index: -4.1000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4429
    Cell Significance Index: -2.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4463
    Cell Significance Index: -20.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4646
    Cell Significance Index: -20.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4766
    Cell Significance Index: -19.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5018
    Cell Significance Index: -3.4000
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.5056
    Cell Significance Index: -3.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5148
    Cell Significance Index: -13.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5157
    Cell Significance Index: -18.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5419
    Cell Significance Index: -20.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5594
    Cell Significance Index: -13.5500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.5603
    Cell Significance Index: -6.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5676
    Cell Significance Index: -15.4500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5847
    Cell Significance Index: -3.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AEBP1 is a protein-coding gene that belongs to the AE-binding protein family. Its primary function is to regulate the expression of genes involved in collagen production and deposition. AEBP1 interacts with various proteins, including calmodulin, metallocarboxypeptidases, and RNA polymerase II, to modulate transcriptional activity. Its expression is significantly increased in fibroblasts, suggesting that AEBP1 plays a critical role in the regulation of collagen fibril organization and tissue remodeling. **Pathways and Functions:** AEBP1 is involved in multiple cellular pathways, including: 1. **Collagen fibril organization:** AEBP1 regulates the organization of collagen fibrils, which is essential for maintaining tissue structure and integrity. 2. **Transcriptional regulation:** AEBP1 interacts with RNA polymerase II to regulate the expression of genes involved in collagen production and deposition. 3. **Metallocarboxypeptidase activity:** AEBP1 interacts with metallocarboxypeptidases to regulate the processing of collagen peptides. 4. **DNA-templated transcription:** AEBP1 regulates the expression of genes involved in DNA-templated transcription, which is essential for maintaining tissue homeostasis. **Clinical Significance:** AEBP1 has significant implications for various diseases, including: 1. **Fibrotic disorders:** AEBP1's role in regulating collagen fibril organization makes it a potential target for the treatment of fibrotic disorders, such as pulmonary fibrosis and liver cirrhosis. 2. **Cancer:** AEBP1's expression in cancer cells suggests that it may play a role in regulating tumor growth and metastasis. 3. **Wound healing:** AEBP1's involvement in collagen fibril organization makes it a potential target for the treatment of wound healing disorders. In conclusion, AEBP1 is a critical regulator of collagen fibril organization and transcriptional activity. Its expression in fibroblasts highlights its importance in maintaining tissue homeostasis, and its involvement in various disease pathways suggests that it may be a valuable target for the treatment of fibrotic disorders and cancer. Further research is necessary to fully elucidate the role of AEBP1 in human disease.

Genular Protein ID: 2598183619

Symbol: AEBP1_HUMAN

Name: Adipocyte enhancer-binding protein 1

UniProtKB Accession Codes:

Q8IUX7 Q14113 Q59ER7 Q6ZSC7 Q7KZ79

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9624159

Title: Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.

PubMed ID: 9624159

DOI: 10.1074/jbc.273.25.15654

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8920928

Title: A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line.

PubMed ID: 8920928

DOI: 10.1006/bbrc.1996.1675

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27023906

Title: Expanding the clinical and genetic heterogeneity of hereditary disorders of connective tissue.

PubMed ID: 27023906

DOI: 10.1007/s00439-016-1660-z

PubMed ID: 29606302

Title: Bi-allelic alterations in AEBP1 lead to defective collagen assembly and connective tissue structure resulting in a variant of Ehlers-Danlos syndrome.

PubMed ID: 29606302

DOI: 10.1016/j.ajhg.2018.02.018

Sequence Information:

  • Length: 1158
  • Mass: 130929
  • Checksum: 1D7F4A20451646AE
  • Sequence:
    • MAAVRGAPLL SCLLALLALC PGGRPQTVLT DDEIEEFLEG FLSELEPEPR EDDVEAPPPP 
EPTPRVRKAQ AGGKPGKRPG TAAEVPPEKT KDKGKKGKKD KGPKVPKESL EGSPRPPKKG 
KEKPPKATKK PKEKPPKATK KPKEKPPKAT KKPKEKPPKA TKKPPSGKRP PILAPSETLE 
WPLPPPPSPG PEELPQEGGA PLSNNWQNPG EETHVEAREH QPEPEEETEQ PTLDYNDQIE 
REDYEDFEYI RRQKQPRPPP SRRRRPERVW PEPPEEKAPA PAPEERIEPP VKPLLPPLPP 
DYGDGYVIPN YDDMDYYFGP PPPQKPDAER QTDEEKEELK KPKKEDSSPK EETDKWAVEK 
GKDHKEPRKG EELEEEWTPT EKVKCPPIGM ESHRIEDNQI RASSMLRHGL GAQRGRLNMQ 
TGATEDDYYD GAWCAEDDAR TQWIEVDTRR TTRFTGVITQ GRDSSIHDDF VTTFFVGFSN 
DSQTWVMYTN GYEEMTFHGN VDKDTPVLSE LPEPVVARFI RIYPLTWNGS LCMRLEVLGC 
SVAPVYSYYA QNEVVATDDL DFRHHSYKDM RQLMKVVNEE CPTITRTYSL GKSSRGLKIY 
AMEISDNPGE HELGEPEFRY TAGIHGNEVL GRELLLLLMQ YLCREYRDGN PRVRSLVQDT 
RIHLVPSLNP DGYEVAAQMG SEFGNWALGL WTEEGFDIFE DFPDLNSVLW GAEERKWVPY 
RVPNNNLPIP ERYLSPDATV STEVRAIIAW MEKNPFVLGA NLNGGERLVS YPYDMARTPT 
QEQLLAAAMA AARGEDEDEV SEAQETPDHA IFRWLAISFA SAHLTLTEPY RGGCQAQDYT 
GGMGIVNGAK WNPRTGTIND FSYLHTNCLE LSFYLGCDKF PHESELPREW ENNKEALLTF 
MEQVHRGIKG VVTDEQGIPI ANATISVSGI NHGVKTASGG DYWRILNPGE YRVTAHAEGY 
TPSAKTCNVD YDIGATQCNF ILARSNWKRI REIMAMNGNR PIPHIDPSRP MTPQQRRLQQ 
RRLQHRLRLR AQMRLRRLNA TTTLGPHTVP PTLPPAPATT LSTTIEPWGL IPPTTAGWEE 
SETETYTEVV TEFGTEVEPE FGTKVEPEFE TQLEPEFETQ LEPEFEEEEE EEKEEEIATG 
QAFPFTTVET YTVNFGDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.