Details for: DDOST
Gene ID: 1650
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DDOST
Ensembl ID: ENSG00000244038
Description: dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 87.02rCSI 68.46%PRS 69.47
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CSI 67.65rCSI 54.7%PRS 64.1
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CSI 56.41rCSI 48.85%PRS 67.69
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CSI 53.72rCSI 66.46%PRS 59.38
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CSI 48.71rCSI 50.91%PRS 60.69
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CSI 45.62rCSI 43.92%PRS 62.72
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CSI 44.8rCSI 40.46%PRS 59.61
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CSI 43.82rCSI 29.13%PRS 65.8
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CSI 37.7rCSI 36.35%PRS 53.39
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CSI 36.88rCSI 56.99%PRS 60.99
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CSI 34.18rCSI 31.6%PRS 81.85
-
CSI 32.39rCSI 40.65%PRS 73.14
-
CSI 31.65rCSI 33.15%PRS 59.15
-
CSI 30.21rCSI 43.57%PRS 72.16
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CSI 29.24rCSI 24.24%PRS 62.1
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CSI 24.98rCSI 26.17%PRS 66.34
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CSI 23.88rCSI 31.3%PRS 86.69
-
CSI 23.87rCSI 34.41%PRS 73.29
-
CSI 22.03rCSI 21.67%PRS 65.35
-
CSI 21.18rCSI 31.26%PRS 78.25
-
CSI 21.07rCSI 18.5%PRS 68.26
-
CSI 20.93rCSI 40.7%PRS 65.74
-
CSI 18.8rCSI 24.99%PRS 69.25
-
CSI 17.73rCSI 51.07%PRS 75.81
-
CSI 16.98rCSI 12.76%PRS 68.24
-
CSI 16.65rCSI 14.78%PRS 60.61
-
CSI 15.62rCSI 45.28%PRS 52.29
-
CSI 14.85rCSI 35.29%PRS 71.54
-
CSI 14.45rCSI 25.47%PRS 59.44
-
CSI 13.49rCSI 20.74%PRS 58.41
-
CSI 13.09rCSI 12.08%PRS 64.07
-
CSI 13.07rCSI 16.76%PRS 67.67
-
CSI 13.05rCSI 13.86%PRS 72.82
-
CSI 12.88rCSI 48.25%PRS 54.62
-
CSI 12.85rCSI 11.96%PRS 63.32
-
CSI 12.82rCSI 18.76%PRS 67.64
-
CSI 12.21rCSI 12.74%PRS 63.07
-
CSI 12.02rCSI 11.87%PRS 85.07
-
CSI 11.94rCSI 9.44%PRS 49.52
-
CSI 11.61rCSI 20.35%PRS 54.53
-
CSI 11.2rCSI 24.66%PRS 67.05
-
CSI 10.94rCSI 11.2%PRS 76.83
-
CSI 10.74rCSI 12.29%PRS 80.9
-
CSI 9.87rCSI 12.3%PRS 73.58
-
CSI 9.66rCSI 11.2%PRS 70.36
-
CSI 9.51rCSI 62.43%PRS 88.1
-
CSI 9.5rCSI 15.22%PRS 82.99
-
CSI 9.49rCSI 11.69%PRS 76.02
-
CSI 9.31rCSI 11.91%PRS 82.87
-
CSI 9.17rCSI 12.71%PRS 63.67
-
CSI 8.99rCSI 55.52%PRS 88.73
-
CSI 8.95rCSI 6.23%PRS 77.89
-
CSI 8.84rCSI 25.35%PRS 82.32
-
CSI 8.82rCSI 9.46%PRS 62.31
-
CSI 8.78rCSI 6.1%PRS 73.93
-
CSI 8.57rCSI 49.88%PRS 71.62
-
CSI 8.42rCSI 6.74%PRS 82.54
-
CSI 8.34rCSI 13.52%PRS 59.32
-
CSI 8.27rCSI 44.11%PRS 91.01
-
CSI 8.23rCSI 26.68%PRS 62.88
-
CSI 8.21rCSI 9.64%PRS 64.97
-
CSI 8.21rCSI 11.22%PRS 68.81
-
CSI 8.13rCSI 12.42%PRS 72.03
-
CSI 8.1rCSI 5.65%PRS 65.5
-
CSI 7.95rCSI 12.16%PRS 75.98
-
CSI 7.81rCSI 9.94%PRS 69.15
-
CSI 7.74rCSI 48.35%PRS 54.36
-
CSI 7.66rCSI 10.46%PRS 64.42
-
CSI 7.64rCSI 14.45%PRS 80.76
-
CSI 7.63rCSI 83.57%PRS 74.9
-
CSI 7.46rCSI 17.71%PRS 66.36
-
CSI 7.42rCSI 9.72%PRS 76.2
-
CSI 7.35rCSI 14.01%PRS 77.19
-
CSI 7.34rCSI 5.55%PRS 76.65
-
CSI 7.26rCSI 8.17%PRS 78.94
-
CSI 7.25rCSI 6.05%PRS 72.9
-
CSI 7.18rCSI 8.6%PRS 78.94
-
CSI 7.18rCSI 5.83%PRS 63.18
-
CSI 7.15rCSI 10.35%PRS 78.53
-
CSI 7.13rCSI 5.12%PRS 76.85
-
CSI 7.05rCSI 12.08%PRS 71.53
-
CSI 7.05rCSI 9.61%PRS 54.44
-
CSI 6.9rCSI 5.17%PRS 87.85
-
CSI 6.86rCSI 9.79%PRS 64.94
-
CSI 6.81rCSI 12.78%PRS 77.33
-
CSI 6.8rCSI 25.68%PRS 45.02
-
CSI 6.73rCSI 5.57%PRS 64.91
-
CSI 6.73rCSI 15.34%PRS 59.04
-
CSI 6.72rCSI 5.79%PRS 68.1
-
CSI 6.71rCSI 9.13%PRS 74.35
-
CSI 6.58rCSI 5.99%PRS 77.26
-
CSI 6.53rCSI 6.17%PRS 62.24
-
CSI 6.51rCSI 5.71%PRS 72.17
-
CSI 6.47rCSI 7.09%PRS 66.51
-
CSI 6.32rCSI 14.46%PRS 62.61
-
CSI 6.31rCSI 13.03%PRS 64.13
-
CSI 6.27rCSI 9.28%PRS 68
-
CSI 6.23rCSI 6.31%PRS 87.22
-
CSI 6.15rCSI 10.97%PRS 76.17
-
CSI 6.07rCSI 7.01%PRS 55.78
-
CSI 0.3rCSI 1.8%PRS 71.9%
-
CSI 0.3rCSI 1.7%PRS 77.9%
-
CSI 0.3rCSI 1.1%PRS 42.7%
-
CSI 0.4rCSI 6.3%PRS 83.1%
-
CSI 0.4rCSI 1.3%PRS 48.5%
-
CSI 0.4rCSI 2.8%PRS 87.1%
-
CSI 0.5rCSI 7.3%PRS 79.2%
-
CSI 0.5rCSI 2.1%PRS 75.3%
-
CSI 0.6rCSI 3.2%PRS 84.7%
-
CSI 0.6rCSI 0.8%PRS 67.6%
-
CSI 0.6rCSI 1.6%PRS 73.9%
-
CSI 0.6rCSI 3.0%PRS 73.7%
-
CSI 0.6rCSI 4.2%PRS 76.9%
-
CSI 0.7rCSI 1.2%PRS 52.2%
-
CSI 0.8rCSI 17.6%PRS 81.2%
-
CSI 0.8rCSI 3.7%PRS 79.6%
-
CSI 0.9rCSI 2.3%PRS 69.8%
-
CSI 0.9rCSI 2.9%PRS 46.0%
-
CSI 1.0rCSI 4.4%PRS 88.9%
-
CSI 1.0rCSI 3.8%PRS 82.5%
-
CSI 1.0rCSI 2.8%PRS 75.2%
-
CSI 1.1rCSI 4.1%PRS 76.9%
-
CSI 1.1rCSI 12.4%PRS 87.3%
-
CSI 1.2rCSI 11.1%PRS 92.0%
-
CSI 1.2rCSI 2.6%PRS 75.1%
-
CSI 1.2rCSI 2.8%PRS 70.0%
-
CSI 1.2rCSI 1.0%PRS 83.7%
-
CSI 1.2rCSI 30.5%PRS 88.9%
-
CSI 1.3rCSI 2.2%PRS 44.3%
-
CSI 1.3rCSI 2.0%PRS 59.0%
-
CSI 1.4rCSI 4.1%PRS 64.0%
-
CSI 1.4rCSI 2.9%PRS 79.8%
-
CSI 1.4rCSI 7.8%PRS 89.3%
-
CSI 1.5rCSI 1.9%PRS 45.6%
-
CSI 1.5rCSI 2.4%PRS 55.0%
-
CSI 1.5rCSI 1.8%PRS 44.0%
-
CSI 1.5rCSI 3.0%PRS 87.7%
-
CSI 1.5rCSI 1.1%PRS 79.1%
-
CSI 1.5rCSI 1.8%PRS 82.0%
-
CSI 1.6rCSI 15.3%PRS 79.5%
-
CSI 1.6rCSI 4.1%PRS 57.6%
-
CSI 1.7rCSI 3.5%PRS 80.5%
-
CSI 1.7rCSI 1.5%PRS 73.5%
-
CSI 1.8rCSI 4.2%PRS 80.3%
-
CSI 1.8rCSI 7.8%PRS 77.0%
-
CSI 1.8rCSI 4.6%PRS 70.7%
-
CSI 1.8rCSI 3.3%PRS 61.7%
-
CSI 1.9rCSI 3.8%PRS 51.7%
-
CSI 1.9rCSI 3.6%PRS 73.1%
-
CSI 2.0rCSI 3.0%PRS 63.4%
-
CSI 2.0rCSI 5.8%PRS 73.9%
-
CSI 2.0rCSI 10.2%PRS 75.3%
-
CSI 2.1rCSI 3.0%PRS 66.1%
-
CSI 2.1rCSI 9.1%PRS 52.9%
-
CSI 2.1rCSI 6.8%PRS 67.6%
-
CSI 2.1rCSI 5.6%PRS 80.7%
-
CSI 2.2rCSI 4.2%PRS 82.3%
-
CSI 2.2rCSI 4.9%PRS 70.7%
-
CSI 2.3rCSI 1.9%PRS 67.1%
-
CSI 2.3rCSI 3.4%PRS 64.0%
-
CSI 2.3rCSI 2.8%PRS 60.8%
-
CSI 2.3rCSI 13.3%PRS 71.9%
-
CSI 2.4rCSI 43.7%PRS 90.0%
-
CSI 2.4rCSI 4.1%PRS 80.5%
-
CSI 2.4rCSI 3.7%PRS 71.7%
-
CSI 2.4rCSI 9.3%PRS 53.4%
-
CSI 2.5rCSI 27.0%PRS 77.4%
-
CSI 2.5rCSI 3.4%PRS 86.4%
-
CSI 2.5rCSI 4.5%PRS 43.4%
-
CSI 2.5rCSI 7.2%PRS 59.3%
-
CSI 2.6rCSI 1.9%PRS 76.1%
-
CSI 2.6rCSI 3.6%PRS 81.8%
-
CSI 2.6rCSI 4.1%PRS 85.7%
-
CSI 2.6rCSI 3.5%PRS 71.7%
-
CSI 2.6rCSI 6.5%PRS 61.2%
-
CSI 2.6rCSI 5.8%PRS 76.2%
-
CSI 2.7rCSI 6.0%PRS 66.5%
-
CSI 2.7rCSI 13.7%PRS 88.4%
-
CSI 2.7rCSI 2.6%PRS 83.4%
-
CSI 2.7rCSI 5.1%PRS 50.9%
-
CSI 2.8rCSI 7.1%PRS 52.1%
-
CSI 2.8rCSI 15.1%PRS 74.9%
-
CSI 2.9rCSI 4.7%PRS 68.0%
-
CSI 2.9rCSI 11.4%PRS 78.2%
-
CSI 2.9rCSI 5.2%PRS 55.8%
-
CSI 2.9rCSI 7.4%PRS 56.9%
-
CSI 3.0rCSI 5.4%PRS 77.7%
-
CSI 3.0rCSI 22.4%PRS 78.5%
-
CSI 3.0rCSI 1.8%PRS 80.0%
-
CSI 3.0rCSI 3.7%PRS 49.4%
-
CSI 3.0rCSI 8.0%PRS 73.8%
-
CSI 3.1rCSI 4.8%PRS 78.3%
-
CSI 3.1rCSI 3.1%PRS 56.1%
-
CSI 3.2rCSI 15.1%PRS 79.0%
-
CSI 3.3rCSI 14.6%PRS 90.2%
-
CSI 3.3rCSI 11.9%PRS 90.9%
-
CSI 3.5rCSI 5.3%PRS 67.0%
-
CSI 3.5rCSI 4.2%PRS 71.7%
-
CSI 3.5rCSI 34.2%PRS 80.6%
-
CSI 3.5rCSI 4.3%PRS 70.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3331852351
Symbol: OST48_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9367678
Title: Genome organization of human 48-kDa oligosaccharyltransferase (DDOST).
PubMed ID: 9367678
PubMed ID: 7788527
Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7788527
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22467853
Title: The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.
PubMed ID: 22467853
DOI: 10.1242/jcs.103952
PubMed ID: 25135935
Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.
PubMed ID: 25135935
PubMed ID: 23606741
Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.
PubMed ID: 23606741
DOI: 10.1242/jcs.115410
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29765154
Title: The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.
PubMed ID: 29765154
PubMed ID: 31831667
Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.
PubMed ID: 31831667
PubMed ID: 22305527
Title: DDOST mutations identified by whole-exome sequencing are implicated in congenital disorders of glycosylation.
PubMed ID: 22305527
Sequence Information:
- Length: 456
- Mass: 50801
- Checksum: 2707ABAC8FF158CB
- Sequence:
MGYFRCARAG SFGRRRKMEP STAARAWALF WLLLPLLGAV CASGPRTLVL LDNLNVRETH SLFFRSLKDR GFELTFKTAD DPSLSLIKYG EFLYDNLIIF SPSVEDFGGN INVETISAFI DGGGSVLVAA SSDIGDPLRE LGSECGIEFD EEKTAVIDHH NYDISDLGQH TLIVADTENL LKAPTIVGKS SLNPILFRGV GMVADPDNPL VLDILTGSST SYSFFPDKPI TQYPHAVGKN TLLIAGLQAR NNARVIFSGS LDFFSDSFFN SAVQKAAPGS QRYSQTGNYE LAVALSRWVF KEEGVLRVGP VSHHRVGETA PPNAYTVTDL VEYSIVIQQL SNGKWVPFDG DDIQLEFVRI DPFVRTFLKK KGGKYSVQFK LPDVYGVFQF KVDYNRLGYT HLYSSTQVSV RPLQHTQYER FIPSAYPYYA SAFSMMLGLF IFSIVFLHMK EKEKSD