DDOST | ENSG00000244038 | NCBI 1650

Details for: DDOST

Gene ID: 1650

Symbol: DDOST

Ensembl ID: ENSG00000244038

Description: dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Asparagine n-linked glycosylation
(R-HSA-446203)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of spike protein
(R-HSA-9694548)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation
(R-HSA-72766)
Translation of structural proteins
(R-HSA-9694635)
Viral infection pathways
(R-HSA-9824446)
Azurophil granule membrane
(GO:0035577)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme activator activity
(GO:0008047)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Oligosaccharyltransferase complex
(GO:0008250)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein glycosylation
(GO:0006486)
Protein n-linked glycosylation
(GO:0006487)
Protein n-linked glycosylation via asparagine
(GO:0018279)
Regulation of protein stability
(GO:0031647)
Response to cytokine
(GO:0034097)
T cell activation
(GO:0042110)

Other Information

Proteins

OST48_HUMAN

Genular Protein ID: 3331852351

Symbol: OST48_HUMAN

Name: N/A

UniProtKB Accession Codes:

P39656 B2RDQ4 B4DJE3 B4DLI2 O43244 Q5VWA5 Q8NI93 Q9BUI2

Database IDs:

Citations:

PubMed ID: 9367678

Title: Genome organization of human 48-kDa oligosaccharyltransferase (DDOST).

PubMed ID: 9367678

DOI: 10.1006/geno.1997.4966

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22467853

Title: The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.

PubMed ID: 22467853

DOI: 10.1242/jcs.103952

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 23606741

Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

PubMed ID: 23606741

DOI: 10.1242/jcs.115410

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29765154

Title: The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.

PubMed ID: 29765154

DOI: 10.1038/s41388-018-0281-5

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

PubMed ID: 22305527

Title: DDOST mutations identified by whole-exome sequencing are implicated in congenital disorders of glycosylation.

PubMed ID: 22305527

DOI: 10.1016/j.ajhg.2011.12.024

Sequence Information:

Length: 456
Mass: 50801
Checksum: 2707ABAC8FF158CB
Sequence:

MGYFRCARAG SFGRRRKMEP STAARAWALF WLLLPLLGAV CASGPRTLVL LDNLNVRETH 
SLFFRSLKDR GFELTFKTAD DPSLSLIKYG EFLYDNLIIF SPSVEDFGGN INVETISAFI 
DGGGSVLVAA SSDIGDPLRE LGSECGIEFD EEKTAVIDHH NYDISDLGQH TLIVADTENL 
LKAPTIVGKS SLNPILFRGV GMVADPDNPL VLDILTGSST SYSFFPDKPI TQYPHAVGKN 
TLLIAGLQAR NNARVIFSGS LDFFSDSFFN SAVQKAAPGS QRYSQTGNYE LAVALSRWVF 
KEEGVLRVGP VSHHRVGETA PPNAYTVTDL VEYSIVIQQL SNGKWVPFDG DDIQLEFVRI 
DPFVRTFLKK KGGKYSVQFK LPDVYGVFQF KVDYNRLGYT HLYSSTQVSV RPLQHTQYER 
FIPSAYPYYA SAFSMMLGLF IFSIVFLHMK EKEKSD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DDOST

Associated with

Other Information

Genome organization of human 48-kDa oligosaccharyltransferase (DDOST). PubMed ID: 9367678

Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7788527

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. PubMed ID: 22467853

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins. PubMed ID: 25135935

OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation. PubMed ID: 23606741

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation. PubMed ID: 29765154

Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. PubMed ID: 31831667

DDOST mutations identified by whole-exome sequencing are implicated in congenital disorders of glycosylation. PubMed ID: 22305527