Details for: DDOST

Gene ID: 1650

Symbol: DDOST

Ensembl ID: ENSG00000244038

Description: dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.32
    Marker Score: 1976
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.31
    Marker Score: 1633
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.26
    Marker Score: 9733
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8741.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.17
    Marker Score: 75083
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.13
    Marker Score: 13842
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.13
    Marker Score: 5787
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.05
    Marker Score: 27042
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.02
    Marker Score: 12914
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.01
    Marker Score: 4187
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.96
    Marker Score: 2824
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.96
    Marker Score: 2085
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.95
    Marker Score: 552
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.92
    Marker Score: 14288.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.9
    Marker Score: 22087
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9
    Marker Score: 1267
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.89
    Marker Score: 5966
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.88
    Marker Score: 1033
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.87
    Marker Score: 3316
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.86
    Marker Score: 2638
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.86
    Marker Score: 2468.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.85
    Marker Score: 510
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.85
    Marker Score: 18590.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.84
    Marker Score: 1344
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.84
    Marker Score: 7516
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.83
    Marker Score: 2693
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.82
    Marker Score: 1601
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.82
    Marker Score: 4325
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.8
    Marker Score: 1303.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.8
    Marker Score: 630
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.8
    Marker Score: 1808
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.77
    Marker Score: 4020.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.77
    Marker Score: 3010.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.77
    Marker Score: 2604
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.77
    Marker Score: 1904
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.74
    Marker Score: 19653
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.71
    Marker Score: 10127
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.7
    Marker Score: 2128
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.69
    Marker Score: 3861
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.67
    Marker Score: 3933.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.65
    Marker Score: 1556.5
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.64
    Marker Score: 573
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.64
    Marker Score: 431
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.64
    Marker Score: 526
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.62
    Marker Score: 1017
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.61
    Marker Score: 831
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.61
    Marker Score: 1516
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.6
    Marker Score: 396
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.6
    Marker Score: 462
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.6
    Marker Score: 3904.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.6
    Marker Score: 4411
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.59
    Marker Score: 1703
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.59
    Marker Score: 2600.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.57
    Marker Score: 5819
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.57
    Marker Score: 375
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.57
    Marker Score: 901.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.57
    Marker Score: 656
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.56
    Marker Score: 765
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.55
    Marker Score: 499
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.55
    Marker Score: 3918
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.54
    Marker Score: 879
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.54
    Marker Score: 1370
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.54
    Marker Score: 15220
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.54
    Marker Score: 52253
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.53
    Marker Score: 4018
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.53
    Marker Score: 967
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.53
    Marker Score: 1253
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.53
    Marker Score: 2354.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.52
    Marker Score: 1551
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.52
    Marker Score: 1356
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.52
    Marker Score: 5861
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.51
    Marker Score: 2434
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.5
    Marker Score: 1561
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.5
    Marker Score: 352
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.5
    Marker Score: 789
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.49
    Marker Score: 823
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.48
    Marker Score: 2582
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.48
    Marker Score: 427
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.48
    Marker Score: 2896
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.47
    Marker Score: 82428
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.47
    Marker Score: 976
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.46
    Marker Score: 361
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.46
    Marker Score: 77076
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.45
    Marker Score: 3623
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 584
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.45
    Marker Score: 2820
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.44
    Marker Score: 1692
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.44
    Marker Score: 2630
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.44
    Marker Score: 1211
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.43
    Marker Score: 768.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.43
    Marker Score: 6137
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.43
    Marker Score: 679
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.43
    Marker Score: 347
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.43
    Marker Score: 1447.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.43
    Marker Score: 1551
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.43
    Marker Score: 2546
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.42
    Marker Score: 4158.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.42
    Marker Score: 3465.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.42
    Marker Score: 310
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.41
    Marker Score: 18993

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Other Information

## Summary DDOST is a protein involved in the regulation of innate immune responses. It is a non-catalytic subunit of an enzyme that is involved in the processing and maturation of spike proteins of viruses. ## Key characteristics * DDOST is a transmembrane protein with a molecular weight of approximately 150 kDa. * It is expressed in a variety of cell types, including plasma cells, epithelial cells, and macrophages. * It is involved in the regulation of innate immune responses to viral infection. ## Pathways and functions * DDOST is involved in the processing and maturation of viral spike proteins. * It is a key regulator of the innate immune response to viral infection. * It is involved in the regulation of the activation of the Advanced glycosylation endproduct receptor (AREG). * It is involved in the regulation of the activation of the Asparagine n-linked glycosylation (ANG) pathway. * It is involved in the regulation of the activation of the Disease, Enzyme activator activity, Immune system, Infectious disease, Innate immune system, Late sars-cov-2 infection events, Maturation of spike protein, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Protein binding, Protein glycosylation, Sars-cov-2 infection, Sars-cov infections, Srp-dependent cotranslational protein targeting to membrane, Translation, Translation of structural proteins, Viral infection pathways. ## Clinical significance DDOST is a potential therapeutic target for the treatment of viral infection. Mutations in DDOST have been linked to the development of viral infections. These mutations can lead to the loss of function of the protein, which can result in the inability of the immune system to control viral infection. Targeting DDOST with small molecule inhibitors could therefore provide a new treatment for viral infection.

Genular Protein ID: 3331852351

Symbol: OST48_HUMAN

Name: N/A

UniProtKB Accession Codes:

P39656 B2RDQ4 B4DJE3 B4DLI2 O43244 Q5VWA5 Q8NI93 Q9BUI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367678

Title: Genome organization of human 48-kDa oligosaccharyltransferase (DDOST).

PubMed ID: 9367678

DOI: 10.1006/geno.1997.4966

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22467853

Title: The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.

PubMed ID: 22467853

DOI: 10.1242/jcs.103952

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 23606741

Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

PubMed ID: 23606741

DOI: 10.1242/jcs.115410

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29765154

Title: The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.

PubMed ID: 29765154

DOI: 10.1038/s41388-018-0281-5

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

PubMed ID: 22305527

Title: DDOST mutations identified by whole-exome sequencing are implicated in congenital disorders of glycosylation.

PubMed ID: 22305527

DOI: 10.1016/j.ajhg.2011.12.024

Sequence Information:

  • Length: 456
  • Mass: 50801
  • Checksum: 2707ABAC8FF158CB
  • Sequence:
    • MGYFRCARAG SFGRRRKMEP STAARAWALF WLLLPLLGAV CASGPRTLVL LDNLNVRETH 
SLFFRSLKDR GFELTFKTAD DPSLSLIKYG EFLYDNLIIF SPSVEDFGGN INVETISAFI 
DGGGSVLVAA SSDIGDPLRE LGSECGIEFD EEKTAVIDHH NYDISDLGQH TLIVADTENL 
LKAPTIVGKS SLNPILFRGV GMVADPDNPL VLDILTGSST SYSFFPDKPI TQYPHAVGKN 
TLLIAGLQAR NNARVIFSGS LDFFSDSFFN SAVQKAAPGS QRYSQTGNYE LAVALSRWVF 
KEEGVLRVGP VSHHRVGETA PPNAYTVTDL VEYSIVIQQL SNGKWVPFDG DDIQLEFVRI 
DPFVRTFLKK KGGKYSVQFK LPDVYGVFQF KVDYNRLGYT HLYSSTQVSV RPLQHTQYER 
FIPSAYPYYA SAFSMMLGLF IFSIVFLHMK EKEKSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.