Genular: Defining Cellular Identity and Function

Details for: Kcnb1

Gene ID: 16500

Symbol: Kcnb1

Ensembl ID: ENSMUSG00000050556

Description: potassium voltage gated channel, Shab-related subfamily, member 1

Associated with

Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Neuronal system
(R-MMU-112316)
Potassium channels
(R-MMU-1296071)
Regulation of insulin secretion
(R-MMU-422356)
Voltage gated potassium channels
(R-MMU-1296072)
Action potential
(GO:0001508)
Apical plasma membrane
(GO:0016324)
Axon
(GO:0030424)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to calcium ion
(GO:0071277)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to nutrient levels
(GO:0031669)
Cholinergic synapse
(GO:0098981)
Clustering of voltage-gated potassium channels
(GO:0045163)
Delayed rectifier potassium channel activity
(GO:0005251)
Dendrite
(GO:0030425)
Dendrite membrane
(GO:0032590)
Exocytosis
(GO:0006887)
Glucose homeostasis
(GO:0042593)
Glutamate receptor signaling pathway
(GO:0007215)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion channel complex
(GO:0034702)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of insulin secretion
(GO:0046676)
Neuronal cell body
(GO:0043025)
Neuronal cell body membrane
(GO:0032809)
Neuron projection
(GO:0043005)
Outward rectifier potassium channel activity
(GO:0015271)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of calcium ion-dependent exocytosis
(GO:0045956)
Positive regulation of catecholamine secretion
(GO:0033605)
Positive regulation of long-term synaptic depression
(GO:1900454)
Positive regulation of norepinephrine secretion
(GO:0010701)
Positive regulation of protein targeting to membrane
(GO:0090314)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Potassium channel activity
(GO:0005267)
Potassium ion export across plasma membrane
(GO:0097623)
Potassium ion transmembrane transport
(GO:0071805)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homooligomerization
(GO:0051260)
Protein localization to plasma membrane
(GO:0072659)
Proximal dendrite
(GO:1990635)
Regulation of action potential
(GO:0098900)
Regulation of motor neuron apoptotic process
(GO:2000671)
Snare binding
(GO:0000149)
Synapse
(GO:0045202)
Transmembrane transport
(GO:0055085)
Transmembrane transporter binding
(GO:0044325)
Vesicle docking involved in exocytosis
(GO:0006904)
Voltage-gated potassium channel activity
(GO:0005249)
Voltage-gated potassium channel complex
(GO:0008076)

Other Information

Proteins

Voltage-gated potassium channel subunit Kv2.1

Genular Protein ID: 343755772

Symbol: KCNB1_MOUSE

Name: Voltage-gated potassium channel subunit Kv2.1

UniProtKB Accession Codes:

Q03717 Q8K0D1

Database IDs:

Citations:

PubMed ID: 2002364

Title: A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties.

PubMed ID: 2002364

DOI: 10.1523/jneurosci.11-03-00869.1991

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10414301

Title: Molecular diversity of K+ channels.

PubMed ID: 10414301

DOI: 10.1111/j.1749-6632.1999.tb11293.x

PubMed ID: 10506487

Title: Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit.

PubMed ID: 10506487

DOI: 10.1161/01.res.85.7.623

PubMed ID: 10921884

Title: Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon.

PubMed ID: 10921884

DOI: 10.1093/emboj/19.15.4036

PubMed ID: 12270920

Title: Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

PubMed ID: 12270920

DOI: 10.1074/jbc.m205532200

PubMed ID: 14684365

Title: Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias.

PubMed ID: 14684365

DOI: 10.1152/ajpheart.00303.2003

PubMed ID: 15858231

Title: Molecular determinants of voltage-gated potassium currents in vascular smooth muscle.

PubMed ID: 15858231

DOI: 10.1385/cbb:42:2:167

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17767909

Title: Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

PubMed ID: 17767909

DOI: 10.1016/j.cmet.2007.07.010

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 19383458

Title: A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.

PubMed ID: 19383458

DOI: 10.1016/j.bpj.2009.01.029

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22056818

Title: AMIGO is an auxiliary subunit of the Kv2.1 potassium channel.

PubMed ID: 22056818

DOI: 10.1038/embor.2011.204

PubMed ID: 23161216

Title: The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.

PubMed ID: 23161216

DOI: 10.1124/jpet.112.199083

PubMed ID: 24494598

Title: Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.

PubMed ID: 24494598

DOI: 10.1111/gbb.12120

PubMed ID: 24477962

Title: A unique ion channel clustering domain on the axon initial segment of mammalian neurons.

PubMed ID: 24477962

DOI: 10.1002/cne.23551

PubMed ID: 19357235

Title: Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons.

PubMed ID: 19357235

DOI: 10.1152/ajpcell.00088.2009

Sequence Information:

Length: 857
Mass: 95591
Checksum: 5FE2D80E58E60710
Sequence:

MPAGMTKHGS RSTSSLPPEP MEIVRSKACS RRVRLNVGGL AHEVLWRTLD RLPRTRLGKL 
RDCNTHDSLL QVCDDYSLED NEYFFDRHPG AFTSILNFYR TGRLHMMEEM CALSFSQELD 
YWGIDEIYLE SCCQARYHQK KEQMNEELKR EAETLREREG EEFDNTCCAE KRKKLWDLLE 
KPNSSVAAKI LAIISIMFIV LSTIALSLNT LPELQSLDEF GQSTDNPQLA HVEAVCIAWF 
TMEYLLRFLS SPKKWKFFKG PLNAIDLLAI LPYYVTIFLT ESNKSVLQFQ NVRRVVQIFR 
IMRILRILKL ARHSTGLQSL GFTLRRSYNE LGLLILFLAM GIMIFSSLVF FAEKDEDDTK 
FKSIPASFWW ATITMTTVGY GDIYPKTLLG KIVGGLCCIA GVLVIALPIP IIVNNFSEFY 
KEQKRQEKAI KRREALERAK RNGSIVSMNM KDAFARSIEM MDIVVEKNGE GVAKKDKVQD 
NHLSPNKWKW TKRALSETSS SKSFETKEQG SPEKARSSSS PQHLNVQQLQ DMYSKMAKTQ 
SQPILNTKEM APQSQPQEEL EMGSMPSPVA PLPTRTEGVI DMRSMSSIDS FISCATDFPE 
ATRFSHSPLA SLSGKSGGST APEVGWRGAL GASGGRLMET NPIPEASRSG FFVESPRSSM 
KTHNPMKLRA LKVNFLEGDP TPLLPALGLY HDPLRNRGGA AAAVAGLECA SLLDKPVLSP 
ESSIYTTASA RTPPRSPEKH TAIAFNFEAG VHQYIDTDTD DEGQLLYSVD SSPPKSLHGS 
TSPKFSLGAR TEKNHFESSP LPTSPKFLRP NCVYASEGLP GKGPGAQEKC KLENHTSPDV 
HMLPGGGAHG STRDQSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kcnb1

Associated with

Other Information

A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties. PubMed ID: 2002364

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular diversity of K+ channels. PubMed ID: 10414301

Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit. PubMed ID: 10506487

Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. PubMed ID: 10921884

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion. PubMed ID: 12270920

Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias. PubMed ID: 14684365

Molecular determinants of voltage-gated potassium currents in vascular smooth muscle. PubMed ID: 15858231

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. PubMed ID: 17767909

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. PubMed ID: 19383458

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

AMIGO is an auxiliary subunit of the Kv2.1 potassium channel. PubMed ID: 22056818

The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. PubMed ID: 23161216

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. PubMed ID: 24494598

A unique ion channel clustering domain on the axon initial segment of mammalian neurons. PubMed ID: 24477962

Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons. PubMed ID: 19357235