Genular: Defining Cellular Identity and Function

Details for: Kcnq1

Gene ID: 16535

Symbol: Kcnq1

Ensembl ID: ENSMUSG00000009545

Description: potassium voltage-gated channel, subfamily Q, member 1

Associated with

Muscle contraction
(R-MMU-397014)
Neuronal system
(R-MMU-112316)
Phase 2 - plateau phase
(R-MMU-5576893)
Phase 3 - rapid repolarisation
(R-MMU-5576890)
Potassium channels
(R-MMU-1296071)
Voltage gated potassium channels
(R-MMU-1296072)
Adrenergic receptor signaling pathway
(GO:0071875)
Atrial cardiac muscle cell action potential
(GO:0086014)
Auditory receptor cell development
(GO:0060117)
Calmodulin binding
(GO:0005516)
Cardiac conduction
(GO:0061337)
Cardiac muscle contraction
(GO:0060048)
Cellular response to camp
(GO:0071320)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chloride ion homeostasis
(GO:0055064)
Cochlea development
(GO:0090102)
Corticosterone secretion
(GO:0035934)
Cytoplasm
(GO:0005737)
Delayed rectifier potassium channel activity
(GO:0005251)
Detection of mechanical stimulus involved in sensory perception of sound
(GO:0050910)
Digestive system process
(GO:0022600)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Erythrocyte differentiation
(GO:0030218)
Gastric acid secretion
(GO:0001696)
Gastrin-induced gastric acid secretion
(GO:0001698)
Glucose metabolic process
(GO:0006006)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Inner ear morphogenesis
(GO:0042472)
Intestinal absorption
(GO:0050892)
Intracellular chloride ion homeostasis
(GO:0030644)
Iodide transport
(GO:0015705)
Lysosome
(GO:0005764)
Membrane repolarization
(GO:0086009)
Membrane repolarization during action potential
(GO:0086011)
Membrane repolarization during atrial cardiac muscle cell action potential
(GO:0098914)
Membrane repolarization during cardiac muscle cell action potential
(GO:0086013)
Membrane repolarization during ventricular cardiac muscle cell action potential
(GO:0098915)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of delayed rectifier potassium channel activity
(GO:1902260)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of voltage-gated potassium channel activity
(GO:1903817)
Non-motile cilium assembly
(GO:1905515)
Outward rectifier potassium channel activity
(GO:0015271)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Positive regulation of cardiac muscle contraction
(GO:0060452)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of potassium ion transmembrane transport
(GO:1901381)
Potassium channel activity
(GO:0005267)
Potassium ion export across plasma membrane
(GO:0097623)
Potassium ion homeostasis
(GO:0055075)
Potassium ion import across plasma membrane
(GO:1990573)
Potassium ion transmembrane transport
(GO:0071805)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein kinase a regulatory subunit binding
(GO:0034237)
Protein phosphatase 1 binding
(GO:0008157)
Regulation of atrial cardiac muscle cell membrane repolarization
(GO:0060372)
Regulation of blood pressure
(GO:0008217)
Regulation of gastric acid secretion
(GO:0060453)
Regulation of heart rate
(GO:0002027)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of membrane potential
(GO:0042391)
Regulation of membrane repolarization
(GO:0060306)
Regulation of transporter activity
(GO:0032409)
Regulation of ventricular cardiac muscle cell membrane repolarization
(GO:0060307)
Regulation of voltage-gated sodium channel activity
(GO:1905150)
Renal absorption
(GO:0070293)
Renal sodium ion absorption
(GO:0070294)
Response to anesthetic
(GO:0072347)
Response to insulin
(GO:0032868)
Rhythmic behavior
(GO:0007622)
Scaffold protein binding
(GO:0097110)
Sensory perception of sound
(GO:0007605)
Social behavior
(GO:0035176)
Sodium ion transport
(GO:0006814)
Stomach development
(GO:0062094)
Transmembrane transport
(GO:0055085)
Transmembrane transporter binding
(GO:0044325)
Ventricular cardiac muscle cell action potential
(GO:0086005)
Voltage-gated potassium channel activity
(GO:0005249)
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
(GO:0086089)
Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
(GO:0086008)
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
(GO:1902282)

Other Information

Proteins

Potassium voltage-gated channel subfamily KQT member 1

Genular Protein ID: 982201484

Symbol: KCNQ1_MOUSE

Name: Potassium voltage-gated channel subfamily KQT member 1

UniProtKB Accession Codes:

P97414 O88702 Q3U4H1 Q7TNZ1 Q7TPL7 Q80VR7

Database IDs:

Citations:

PubMed ID: 15004216

Title: Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current.

PubMed ID: 15004216

DOI: 10.1124/jpet.103.063743

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8900282

Title: K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current.

PubMed ID: 8900282

DOI: 10.1038/384078a0

PubMed ID: 9618174

Title: Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.

PubMed ID: 9618174

DOI: 10.1093/hmg/7.7.1149

PubMed ID: 11120752

Title: Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.

PubMed ID: 11120752

DOI: 10.1172/jci10897

PubMed ID: 16314573

Title: KCNQ1-dependent transport in renal and gastrointestinal epithelia.

PubMed ID: 16314573

DOI: 10.1073/pnas.0505860102

PubMed ID: 17597584

Title: Kcnq1 contributes to an adrenergic-sensitive steady-state K+ current in mouse heart.

PubMed ID: 17597584

DOI: 10.1016/j.bbrc.2007.06.038

PubMed ID: 19491250

Title: KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion.

PubMed ID: 19491250

DOI: 10.1113/jphysiol.2009.173302

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24595108

Title: KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

PubMed ID: 24595108

DOI: 10.1126/scisignal.2005025

Sequence Information:

Length: 668
Mass: 74514
Checksum: 8CE35CBA3102B85B
Sequence:

MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY APIAPTGAPG 
LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL ARTHIQGRVY NFLERPTGWK 
CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR 
SKYVGIWGRL RFARKPISII DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV 
DRQGGTWRLL GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD 
ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF ALKVQQKQRQ 
KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR SHTLLSPSPK PKKSVMVKKK 
KFKLDKDNGM SPGEKMFNVP HITYDPPEDR RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR 
TNSFAEDLDL EGETLLTPIT HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV 
IEQYSQGHLN LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ 
LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS LPTYEQLTVP 
QTGPDEGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kcnq1

Associated with

Other Information

Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current. PubMed ID: 15004216

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. PubMed ID: 8900282

Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. PubMed ID: 9618174

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. PubMed ID: 11120752

KCNQ1-dependent transport in renal and gastrointestinal epithelia. PubMed ID: 16314573

Kcnq1 contributes to an adrenergic-sensitive steady-state K+ current in mouse heart. PubMed ID: 17597584

KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion. PubMed ID: 19491250

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. PubMed ID: 24595108