Details for: Kdr
Associated with
Other Information
Genular Protein ID: 3293646208
Symbol: VGFR2_MOUSE
Name: Fetal liver kinase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7681362
Title: High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
PubMed ID: 7681362
PubMed ID: 1717995
Title: A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
PubMed ID: 1717995
PubMed ID: 8423988
Title: NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo.
PubMed ID: 8423988
PubMed ID: 19668192
Title: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.
PubMed ID: 19668192
DOI: 10.1038/nm.2018
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7559454
Title: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
PubMed ID: 7559454
PubMed ID: 8356051
Title: Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.
PubMed ID: 8356051
PubMed ID: 7596435
Title: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
PubMed ID: 7596435
DOI: 10.1038/376062a0
PubMed ID: 10878616
Title: Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution.
PubMed ID: 10878616
DOI: 10.1002/1097-0177(200007)218:3<507::aid-dvdy1012>3.0.co;2-5
PubMed ID: 12023952
Title: The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.
PubMed ID: 12023952
PubMed ID: 12881528
Title: Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
PubMed ID: 12881528
PubMed ID: 12796773
Title: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
PubMed ID: 12796773
DOI: 10.1038/nm884
PubMed ID: 15026417
Title: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
PubMed ID: 15026417
PubMed ID: 15673613
Title: The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation.
PubMed ID: 15673613
PubMed ID: 17702744
Title: Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.
PubMed ID: 17702744
PubMed ID: 19635461
Title: Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.
PubMed ID: 19635461
PubMed ID: 19652084
Title: Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.
PubMed ID: 19652084
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20705758
Title: Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis.
PubMed ID: 20705758
Sequence Information:
- Length: 1345
- Mass: 150462
- Checksum: 11859F8A58A33A39
- Sequence:
MESKALLAVA LWFCVETRAA SVGLPGDFLH PPKLSTQKDI LTILANTTLQ ITCRGQRDLD WLWPNAQRDS EERVLVTECG GGDSIFCKTL TIPRVVGNDT GAYKCSYRDV DIASTVYVYV RDYRSPFIAS VSDQHGIVYI TENKNKTVVI PCRGSISNLN VSLCARYPEK RFVPDGNRIS WDSEIGFTLP SYMISYAGMV FCEAKINDET YQSIMYIVVV VGYRIYDVIL SPPHEIELSA GEKLVLNCTA RTELNVGLDF TWHSPPSKSH HKKIVNRDVK PFPGTVAKMF LSTLTIESVT KSDQGEYTCV ASSGRMIKRN RTFVRVHTKP FIAFGSGMKS LVEATVGSQV RIPVKYLSYP APDIKWYRNG RPIESNYTMI VGDELTIMEV TERDAGNYTV ILTNPISMEK QSHMVSLVVN VPPQIGEKAL ISPMDSYQYG TMQTLTCTVY ANPPLHHIQW YWQLEEACSY RPGQTSPYAC KEWRHVEDFQ GGNKIEVTKN QYALIEGKNK TVSTLVIQAA NVSALYKCEA INKAGRGERV ISFHVIRGPE ITVQPAAQPT EQESVSLLCT ADRNTFENLT WYKLGSQATS VHMGESLTPV CKNLDALWKL NGTMFSNSTN DILIVAFQNA SLQDQGDYVC SAQDKKTKKR HCLVKQLIIL ERMAPMITGN LENQTTTIGE TIEVTCPASG NPTPHITWFK DNETLVEDSG IVLRDGNRNL TIRRVRKEDG GLYTCQACNV LGCARAETLF IIEGAQEKTN LEVIILVGTA VIAMFFWLLL VIVLRTVKRA NEGELKTGYL SIVMDPDELP LDERCERLPY DASKWEFPRD RLKLGKPLGR GAFGQVIEAD AFGIDKTATC KTVAVKMLKE GATHSEHRAL MSELKILIHI GHHLNVVNLL GACTKPGGPL MVIVEFCKFG NLSTYLRGKR NEFVPYKSKG ARFRQGKDYV GELSVDLKRR LDSITSSQSS ASSGFVEEKS LSDVEEEEAS EELYKDFLTL EHLICYSFQV AKGMEFLASR KCIHRDLAAR NILLSEKNVV KICDFGLARD IYKDPDYVRK GDARLPLKWM APETIFDRVY TIQSDVWSFG VLLWEIFSLG ASPYPGVKID EEFCRRLKEG TRMRAPDYTT PEMYQTMLDC WHEDPNQRPS FSELVEHLGN LLQANAQQDG KDYIVLPMSE TLSMEEDSGL SLPTSPVSCM EEEEVCDPKF HYDNTAGISH YLQNSKRKSR PVSVKTFEDI PLEEPEVKVI PDDSQTDSGM VLASEELKTL EDRNKLSPSF GGMMPSKSRE SVASEGSNQT SGYQSGYHSD DTDTTVYSSD EAGLLKMVDA AVHADSGTTL RSPPV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.