Genular: Defining Cellular Identity and Function

Details for: Kif5b

Gene ID: 16573

Symbol: Kif5b

Ensembl ID: ENSMUSG00000006740

Description: kinesin family member 5B

Associated with

Adaptive immune system
(R-MMU-1280218)
Copi-dependent golgi-to-er retrograde traffic
(R-MMU-6811434)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Golgi-to-er retrograde transport
(R-MMU-8856688)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Kinesins
(R-MMU-983189)
Membrane trafficking
(R-MMU-199991)
Mhc class ii antigen presentation
(R-MMU-2132295)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate ktn1
(R-MMU-5625970)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Vesicle-mediated transport
(R-MMU-5653656)
Anterograde axonal protein transport
(GO:0099641)
Anterograde dendritic transport of neurotransmitter receptor complex
(GO:0098971)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Axonal growth cone
(GO:0044295)
Axon guidance
(GO:0007411)
Cellular response to type ii interferon
(GO:0071346)
Centriolar satellite
(GO:0034451)
Centrosome localization
(GO:0051642)
Ciliary rootlet
(GO:0035253)
Cytoplasm
(GO:0005737)
Cytoplasm organization
(GO:0007028)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endocytic vesicle
(GO:0030139)
Identical protein binding
(GO:0042802)
Jun kinase binding
(GO:0008432)
Kinesin complex
(GO:0005871)
Lysosome
(GO:0005764)
Lysosome localization
(GO:0032418)
Membrane
(GO:0016020)
Membrane-bounded organelle
(GO:0043227)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule-based process
(GO:0007017)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule lateral binding
(GO:0099609)
Microtubule motor activity
(GO:0003777)
Mitochondrial transport
(GO:0006839)
Mitochondrion
(GO:0005739)
Mitochondrion transport along microtubule
(GO:0047497)
Mitocytosis
(GO:0160040)
Natural killer cell mediated cytotoxicity
(GO:0042267)
Neuron projection
(GO:0043005)
Nucleotide binding
(GO:0000166)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytic vesicle
(GO:0045335)
Plus-end-directed microtubule motor activity
(GO:0008574)
Plus-end-directed vesicle transport along microtubule
(GO:0072383)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of intracellular protein transport
(GO:0090316)
Positive regulation of potassium ion transport
(GO:0043268)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of vesicle fusion
(GO:0031340)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of membrane potential
(GO:0042391)
Retrograde neuronal dense core vesicle transport
(GO:1990049)
Stress granule disassembly
(GO:0035617)
Synaptic vesicle transport
(GO:0048489)
Vesicle
(GO:0031982)
Vesicle transport along microtubule
(GO:0047496)

Other Information

Proteins

Kinesin-1 heavy chain
Q9CUT6_MOUSE

Genular Protein ID: 575743009

Symbol: KINH_MOUSE

Name: Kinesin-1 heavy chain

UniProtKB Accession Codes:

Q61768 O08711 Q5BL10 Q61580

Database IDs:

Citations:

PubMed ID: 9112396

Title: Suppression of the expression of a pancreatic beta-cell form of the kinesin heavy chain by antisense oligonucleotides inhibits insulin secretion from primary cultures of mouse beta-cells.

PubMed ID: 9112396

DOI: 10.1210/endo.138.5.5139

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8170981

Title: Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization.

PubMed ID: 8170981

DOI: 10.1073/pnas.91.9.3744

PubMed ID: 9657148

Title: Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.

PubMed ID: 9657148

DOI: 10.1016/s0092-8674(00)81459-2

PubMed ID: 11986669

Title: Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.

PubMed ID: 11986669

DOI: 10.1038/nature743

PubMed ID: 17532644

Title: Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.

PubMed ID: 17532644

DOI: 10.1016/j.mcn.2007.04.008

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19886865

Title: TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis.

PubMed ID: 19886865

DOI: 10.1042/bc20090091

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21976701

Title: Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.

PubMed ID: 21976701

DOI: 10.1091/mbc.e11-01-0068

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 963
Mass: 109551
Checksum: C3D3461A0C314901
Sequence:

MADPAECNIK VMCRFRPLNE SEVNRGDKYV AKFQGEDTVM IASKPYAFDR VFQSSTSQEQ 
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY 
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM 
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK 
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI 
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKTLRNTIQW 
LENELNRWRN GETVPIDEQF DKEKANLEAF TADKDIAITS DKPAAAVGMA GSFTDAERRK 
CEEELAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE 
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL 
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE 
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL 
EESVDSLGEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR 
DEVEAKEKLI TDLQDQNQKM VLEQERLRVE HERLKATDQE KSRKLHELTV MQDRREQARQ 
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEVDSD DTGGSAAQKQ KISFLENNLE 
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD 
RIKEAVRSKN MARRGHSAQI AKPIRPGQHP AASPTHPGTV RGGGSFVQNN QPVGLRGGGG 
KQS

Genular Protein ID: 3992566585

Symbol: Q9CUT6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9CUT6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 67
Mass: 6963
Checksum: CC3571D0D20D26AF
Sequence:

QEVGRIKEAV RSKNMARRGH SAQIAKPIRP GQHPAASPTH PGTVRGGGSF VQNNQPVGLR 
GGGGKQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kif5b

Associated with

Other Information

Suppression of the expression of a pancreatic beta-cell form of the kinesin heavy chain by antisense oligonucleotides inhibits insulin secretion from primary cultures of mouse beta-cells. PubMed ID: 9112396

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. PubMed ID: 8170981

Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. PubMed ID: 9657148

Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. PubMed ID: 11986669

Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. PubMed ID: 17532644

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. PubMed ID: 19886865

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. PubMed ID: 21976701

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073