Genular: Defining Cellular Identity and Function

Details for: Kl

Gene ID: 16591

Symbol: Kl

Ensembl ID: ENSMUSG00000058488

Description: klotho

Associated with

Downstream signaling of activated fgfr1
(R-MMU-5654687)
Fgfr1 ligand binding and activation
(R-MMU-190242)
Fgfr1c and klotho ligand binding and activation
(R-MMU-190374)
Frs-mediated fgfr1 signaling
(R-MMU-5654693)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipase c-mediated cascade: fgfr1
(R-MMU-5654219)
Pi-3k cascade:fgfr1
(R-MMU-5654689)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc-mediated cascade:fgfr1
(R-MMU-5654688)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signal transduction
(R-MMU-162582)
Beta-glucuronidase activity
(GO:0004566)
Calcium ion homeostasis
(GO:0055074)
Carbohydrate metabolic process
(GO:0005975)
Determination of adult lifespan
(GO:0008340)
Energy reserve metabolic process
(GO:0006112)
Extracellular region
(GO:0005576)
Fibroblast growth factor binding
(GO:0017134)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Hydrolase activity, hydrolyzing o-glycosyl compounds
(GO:0004553)
Membrane
(GO:0016020)
Metabolic process
(GO:0008152)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Norepinephrine biosynthetic process
(GO:0042421)
Plasma membrane
(GO:0005886)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of mapkkk cascade by fibroblast growth factor receptor signaling pathway
(GO:0090080)
Protein binding
(GO:0005515)

Other Information

Proteins

Klotho

Genular Protein ID: 2093328663

Symbol: KLOT_MOUSE

Name: Klotho

UniProtKB Accession Codes:

O35082 B2RR78 O70175 O70621

Database IDs:

Citations:

PubMed ID: 9363890

Title: Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed ID: 9363890

DOI: 10.1038/36285

PubMed ID: 9537505

Title: Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein.

PubMed ID: 9537505

DOI: 10.1016/s0014-5793(98)00127-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10631108

Title: Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.

PubMed ID: 10631108

DOI: 10.1006/bbrc.1999.2009

PubMed ID: 11095966

Title: Disruption of klotho gene causes an abnormal energy homeostasis in mice.

PubMed ID: 11095966

DOI: 10.1006/bbrc.2000.3864

PubMed ID: 11016890

Title: Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging.

PubMed ID: 11016890

DOI: 10.1053/meta.2000.8606

PubMed ID: 11411791

Title: Upregulation of the klotho gene expression by thyroid hormone and during adipose differentiation in 3T3-L1 adipocytes.

PubMed ID: 11411791

DOI: 10.1016/s0024-3205(01)01092-x

PubMed ID: 12204354

Title: Expression of Klotho protein in the inner ear.

PubMed ID: 12204354

DOI: 10.1016/s0378-5955(02)00483-5

PubMed ID: 14528024

Title: Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system.

PubMed ID: 14528024

DOI: 10.1210/me.2003-0048

PubMed ID: 15485693

Title: HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.

PubMed ID: 15485693

DOI: 10.1016/j.cardiores.2004.07.011

PubMed ID: 15665504

Title: Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.

PubMed ID: 15665504

DOI: 10.1247/csf.29.91

PubMed ID: 15135068

Title: Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.

PubMed ID: 15135068

DOI: 10.1016/j.febslet.2004.03.090

PubMed ID: 14701853

Title: Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.

PubMed ID: 14701853

DOI: 10.1074/jbc.m312392200

PubMed ID: 16123266

Title: Suppression of aging in mice by the hormone Klotho.

PubMed ID: 16123266

DOI: 10.1126/science.1112766

PubMed ID: 17086194

Title: Klotho converts canonical FGF receptor into a specific receptor for FGF23.

PubMed ID: 17086194

DOI: 10.1038/nature05315

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1014
Mass: 116398
Checksum: 24BD772A1F81B8EC
Sequence:

MLARAPPRRP PRLVLLRLLL LHLLLLALRA RCLSAEPGQG AQTWARFARA PAPEAAGLLH 
DTFPDGFLWA VGSAAYQTEG GWRQHGKGAS IWDTFTHHSG AAPSDSPIVV APSGAPSPPL 
SSTGDVASDS YNNVYRDTEG LRELGVTHYR FSISWARVLP NGTAGTPNRE GLRYYRRLLE 
RLRELGVQPV VTLYHWDLPQ RLQDTYGGWA NRALADHFRD YAELCFRHFG GQVKYWITID 
NPYVVAWHGY ATGRLAPGVR GSSRLGYLVA HNLLLAHAKV WHLYNTSFRP TQGGRVSIAL 
SSHWINPRRM TDYNIRECQK SLDFVLGWFA KPIFIDGDYP ESMKNNLSSL LPDFTESEKR 
LIRGTADFFA LSFGPTLSFQ LLDPNMKFRQ LESPNLRQLL SWIDLEYNHP PIFIVENGWF 
VSGTTKRDDA KYMYYLKKFI METLKAIRLD GVDVIGYTAW SLMDGFEWHR GYSIRRGLFY 
VDFLSQDKEL LPKSSALFYQ KLIEDNGFPP LPENQPLEGT FPCDFAWGVV DNYVQVDTTL 
SQFTDPNVYL WDVHHSKRLI KVDGVVAKKR KPYCVDFSAI RPQITLLREM RVTHFRFSLD 
WALILPLGNQ TQVNHTVLHF YRCMISELVH ANITPVVALW QPAAPHQGLP HALAKHGAWE 
NPHTALAFAD YANLCFKELG HWVNLWITMN EPNTRNMTYR AGHHLLRAHA LAWHLYDDKF 
RAAQKGKISI ALQADWIEPA CPFSQNDKEV AERVLEFDIG WLAEPIFGSG DYPRVMRDWL 
NQKNNFLLPY FTEDEKKLVR GSFDFLAVSH YTTILVDWEK EDPMKYNDYL EVQEMTDITW 
LNSPSQVAVV PWGLRKVLNW LRFKYGDLPM YVTANGIDDD PHAEQDSLRI YYIKNYVNEA 
LKAYVLDDIN LCGYFAYSLS DRSAPKSGFY RYAANQFEPK PSMKHYRKII DSNGFLGSGT 
LGRFCPEEYT VCTECGFFQT RKSLLVFISF LVFTFIISLA LIFHYSKKGQ RSYK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kl

Associated with

Other Information

Mutation of the mouse klotho gene leads to a syndrome resembling ageing. PubMed ID: 9363890

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. PubMed ID: 9537505

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. PubMed ID: 10631108

Disruption of klotho gene causes an abnormal energy homeostasis in mice. PubMed ID: 11095966

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. PubMed ID: 11016890

Upregulation of the klotho gene expression by thyroid hormone and during adipose differentiation in 3T3-L1 adipocytes. PubMed ID: 11411791

Expression of Klotho protein in the inner ear. PubMed ID: 12204354

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. PubMed ID: 14528024

HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. PubMed ID: 15485693

Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. PubMed ID: 15665504

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. PubMed ID: 15135068

Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. PubMed ID: 14701853

Suppression of aging in mice by the hormone Klotho. PubMed ID: 16123266

Klotho converts canonical FGF receptor into a specific receptor for FGF23. PubMed ID: 17086194

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079