Details for: Klf2

Gene ID: 16598

Symbol: Klf2

Ensembl ID: ENSMUSG00000055148

Description: Kruppel-like transcription factor 2 (lung)

Associated with

  • Cell morphogenesis
    (GO:0000902)
  • Cellular response to fluid shear stress
    (GO:0071498)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Cellular stress response to acid chemical
    (GO:0097533)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Epigenetic regulation of gene expression
    (GO:0040029)
  • Erythrocyte homeostasis
    (GO:0034101)
  • Erythrocyte maturation
    (GO:0043249)
  • In utero embryonic development
    (GO:0001701)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism growth
    (GO:0035264)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of sprouting angiogenesis
    (GO:1903671)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of retinoic acid receptor signaling pathway
    (GO:0048386)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Type i pneumocyte differentiation
    (GO:0060509)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 3177478901

Symbol: KLF2_MOUSE

Name: Krueppel-like factor 2

UniProtKB Accession Codes:

Q60843 B2RS60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 34 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 7565748

Title: Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family.

PubMed ID: 7565748

DOI: 10.1128/mcb.15.11.5957

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375995

Title: Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.

PubMed ID: 11375995

DOI: 10.1074/jbc.m103670200

PubMed ID: 15003522

Title: WWP1-dependent ubiquitination and degradation of the lung Kruppel-like factor, KLF2.

PubMed ID: 15003522

DOI: 10.1016/j.bbrc.2004.02.033

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 354
  • Mass: 37657
  • Checksum: 31A99C00DFC5B810
  • Sequence:
    • MALSEPILPS FATFASPCER GLQERWPRNE PEAGGTDEDL NNVLDFILSM GLDGLGAENP 
PEPPPQPPPP AFYYPEPGAP PPYSIPAASL GTELLRPDLD PPQGPALHGR FLLAPPGRLV 
KAEPPEVDGG GYGCAPGLAH GPRGLKLEGA PGATGACMRG PAGRPPPPPD TPPLSPDGPL 
RIPASGPRNP FPPPFGPGPS FGGPGPALHY GPPAPGAFGL FEDAAAAAAA LGLAPPATRG 
LLTPPSSPLE LLEAKPKRGR RSWPRKRAAT HTCSYTNCGK TYTKSSHLKA HLRTHTGEKP 
YHCNWEGCGW KFARSDELTR HYRKHTGHRP FQCHLCDRAF SRSDHLALHM KRHM

Genular Protein ID: 585278075

Symbol: Q3V293_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V293

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 354
  • Mass: 37585
  • Checksum: A00A0BFE95E713A5
  • Sequence:
    • MALSEPILPS FATFASPCER GLQGRWPRNE PEAGGTDEDL NNVLDFILSM GLDGLGAENP 
PEPPPQPPPP AFYYPEPGAP PPYSIPAASL GTELLRPDLD PPQGPALHGR FLLAPPGRLV 
KAEPPEVDGG GYGCAPGLAH GPRGLKLEGA PGATGACMRG PAGRPPPPPD TPPLSPDGPL 
RIPASGPRNP FPPPFGPGPS FGGPGPALHY GPPAPGAFGL FEDAAAAAAA LGLAPPATRG 
LLTPPSSPLE LLEAKPKRGR RSWPRKRAAT HTCSYTNCGK TYTKSSHLKA HLRTHTGEKP 
YHCNWEGCGW KFARSDELTR HYRKHTGHRP FQCHLCDRAF SRSDHLALHM KRHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.