Details for: TLE5

Gene ID: 166

Symbol: TLE5

Ensembl ID: ENSG00000104964

Description: TLE family member 5, transcriptional modulator

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 5.46
    Marker Score: 3996
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 4.09
    Marker Score: 2394
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.89
    Marker Score: 3302
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.68
    Marker Score: 194766.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.64
    Marker Score: 3245
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.59
    Marker Score: 3540
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.53
    Marker Score: 11155
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.26
    Marker Score: 7960
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.2
    Marker Score: 2812.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.18
    Marker Score: 8911
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.07
    Marker Score: 2869
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.02
    Marker Score: 1054
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.02
    Marker Score: 8812
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.98
    Marker Score: 1490.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.96
    Marker Score: 4355
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.93
    Marker Score: 21810
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.92
    Marker Score: 7356
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.91
    Marker Score: 1255.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.87
    Marker Score: 6050.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.85
    Marker Score: 28222.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.84
    Marker Score: 1566
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.84
    Marker Score: 7598
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.77
    Marker Score: 4592
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.77
    Marker Score: 1668.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.76
    Marker Score: 27935.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.74
    Marker Score: 6235.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.73
    Marker Score: 1525
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.66
    Marker Score: 877
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.65
    Marker Score: 939
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.58
    Marker Score: 2032.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.58
    Marker Score: 3554
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.57
    Marker Score: 796
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.55
    Marker Score: 2687
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 2.54
    Marker Score: 1730
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.5
    Marker Score: 21701
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.48
    Marker Score: 1595
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.47
    Marker Score: 1684
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.47
    Marker Score: 2321
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.44
    Marker Score: 2358
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.43
    Marker Score: 1774
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.43
    Marker Score: 28238
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.42
    Marker Score: 4326
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.4
    Marker Score: 2435
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.39
    Marker Score: 1592
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.38
    Marker Score: 31690
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.38
    Marker Score: 3505.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.38
    Marker Score: 697
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.38
    Marker Score: 1110
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.36
    Marker Score: 717
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.36
    Marker Score: 4048
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.36
    Marker Score: 1986
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.35
    Marker Score: 1660
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.32
    Marker Score: 10750
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.32
    Marker Score: 23365
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.29
    Marker Score: 14616
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.28
    Marker Score: 14560
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.28
    Marker Score: 2534
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.27
    Marker Score: 2403
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.26
    Marker Score: 3197
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.25
    Marker Score: 2531
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.25
    Marker Score: 8330
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.24
    Marker Score: 4693
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.24
    Marker Score: 1496
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.21
    Marker Score: 3202
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.2
    Marker Score: 29041
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.2
    Marker Score: 4314
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.19
    Marker Score: 1133
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.18
    Marker Score: 5530
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.17
    Marker Score: 29212
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.17
    Marker Score: 3563
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.16
    Marker Score: 5266.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.15
    Marker Score: 1062
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.15
    Marker Score: 5847
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.12
    Marker Score: 9130
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.11
    Marker Score: 609
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.11
    Marker Score: 73009
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.1
    Marker Score: 7458
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.1
    Marker Score: 2228.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.06
    Marker Score: 1269
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.06
    Marker Score: 767
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.06
    Marker Score: 8541
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.05
    Marker Score: 2229
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.05
    Marker Score: 1158
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.05
    Marker Score: 775
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.05
    Marker Score: 489
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.04
    Marker Score: 12123.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.04
    Marker Score: 968
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.04
    Marker Score: 1450
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.04
    Marker Score: 13261
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.03
    Marker Score: 4452
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.02
    Marker Score: 3588
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.02
    Marker Score: 22731
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.02
    Marker Score: 2110.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.01
    Marker Score: 463
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.01
    Marker Score: 2159
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2
    Marker Score: 2160
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2
    Marker Score: 1918
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2
    Marker Score: 2072
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.98
    Marker Score: 1163
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.98
    Marker Score: 1891

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Other Information

**Key characteristics**: * TLE5 is a transmembrane protein with a cytoplasmic domain and a nuclear transactivation domain. * It is expressed in a variety of cell types, including effector memory CD4-positive T cells, alpha-beta T cells, and macrophages. * It is involved in the regulation of immune responses, developmental processes, and cancer progression. **Pathways and functions**: * TLE5 negatively regulates the canonical Wnt signaling pathway, which is essential for maintaining tissue homeostasis and preventing cancer. * It does this by promoting the degradation of beta-catenin through the destruction complex, thereby blocking its interaction with co-repressors and allowing beta-catenin to translocate to the nucleus. * TLE5 also negatively regulates the transcription of DNA-templated genes and suppresses the expression of WNT target genes. * It plays a role in the regulation of cell growth, proliferation, and differentiation by modulating the expression of various target genes involved in these processes. **Clinical significance**: * Mutations in the TLE5 gene have been linked to several human cancers, including colorectal, lung, and breast cancer. * Targeting TLE5 has emerged as a promising therapeutic approach for these malignancies, as it can inhibit tumor growth and metastasis. * However, further research is needed to develop effective TLE5 inhibitors that can be safely used in humans. **Additional information**: * TLE5 is a conserved protein with significant sequence similarities in mammals. * It is a member of the TLE family of transcriptional modulators, which also include TLE1, TLE2, and TLE4. * TLE5 is a highly regulated gene, with its expression being controlled by various factors including growth factors, cytokines, and other signaling pathways.

Genular Protein ID: 2813430557

Symbol: TLE5_HUMAN

Name: Amino-terminal enhancer of split

UniProtKB Accession Codes:

Q08117 B2RBL0 Q12808 Q14CJ1 Q96TG9 Q9UDY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9809752

Title: Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein.

PubMed ID: 9809752

DOI: 10.1089/dna.1998.17.911

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8365415

Title: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

PubMed ID: 8365415

DOI: 10.1111/j.1432-1033.1993.tb18151.x

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 11390640

Title: Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.

PubMed ID: 11390640

DOI: 10.1128/mcb.21.13.4110-4118.2001

PubMed ID: 12441302

Title: Six3 and Six6 activity is modulated by members of the groucho family.

PubMed ID: 12441302

DOI: 10.1242/dev.00185

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

Sequence Information:

  • Length: 197
  • Mass: 21970
  • Checksum: 3851663AA6921A9F
  • Sequence:
    • MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH 
YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN 
SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK 
NGHDGDTHQE DDGEKSD

Genular Protein ID: 1555992136

Symbol: Q8WY48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WY48

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 3 SAM 1

Sequence Information:

  • Length: 103
  • Mass: 11192
  • Checksum: 5B4189E7EB29CEAA
  • Sequence:
    • MGDQVPREQD LAKRSSPGPS PVLNMCNRQS AWATALSPWY CMHAMLAAPF PSWAPRVSPD 
PGSQVCSHLH LPHSPPLLVP DTSTPTWSSP IAHKRGGTRD ELS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.