Details for: TLE5

Gene ID: 166

Symbol: TLE5

Ensembl ID: ENSG00000104964

Description: TLE family member 5, transcriptional modulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 485.3894
    Cell Significance Index: -75.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 296.5975
    Cell Significance Index: -75.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.4163
    Cell Significance Index: -86.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 169.3089
    Cell Significance Index: -87.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.4954
    Cell Significance Index: -79.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.9805
    Cell Significance Index: -82.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.5966
    Cell Significance Index: -60.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.1076
    Cell Significance Index: -39.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1724
    Cell Significance Index: 113.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.9259
    Cell Significance Index: 253.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5936
    Cell Significance Index: 167.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 3.0640
    Cell Significance Index: 881.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9641
    Cell Significance Index: 364.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9356
    Cell Significance Index: 22.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.8764
    Cell Significance Index: 518.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4199
    Cell Significance Index: 71.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2494
    Cell Significance Index: 308.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2334
    Cell Significance Index: 116.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5607
    Cell Significance Index: 852.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4822
    Cell Significance Index: 297.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4422
    Cell Significance Index: 637.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3377
    Cell Significance Index: 62.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2291
    Cell Significance Index: 55.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1233
    Cell Significance Index: 111.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0454
    Cell Significance Index: 374.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9936
    Cell Significance Index: 9.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9117
    Cell Significance Index: 116.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8161
    Cell Significance Index: 49.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7306
    Cell Significance Index: 19.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5532
    Cell Significance Index: 65.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5348
    Cell Significance Index: 15.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5170
    Cell Significance Index: 31.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4954
    Cell Significance Index: 35.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4666
    Cell Significance Index: 60.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4652
    Cell Significance Index: 88.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4135
    Cell Significance Index: 30.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4051
    Cell Significance Index: 8.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2923
    Cell Significance Index: 8.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2816
    Cell Significance Index: 1.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2713
    Cell Significance Index: 4.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2597
    Cell Significance Index: 51.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0741
    Cell Significance Index: 3.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0563
    Cell Significance Index: 41.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0423
    Cell Significance Index: 19.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0277
    Cell Significance Index: 52.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0120
    Cell Significance Index: 9.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0050
    Cell Significance Index: 3.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0042
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0153
    Cell Significance Index: -2.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0213
    Cell Significance Index: -39.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0357
    Cell Significance Index: -55.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0376
    Cell Significance Index: -2.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0551
    Cell Significance Index: -74.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0827
    Cell Significance Index: -13.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0864
    Cell Significance Index: -64.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1007
    Cell Significance Index: -2.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1195
    Cell Significance Index: -12.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1283
    Cell Significance Index: -72.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1506
    Cell Significance Index: -94.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1714
    Cell Significance Index: -19.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1742
    Cell Significance Index: -10.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1844
    Cell Significance Index: -5.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1981
    Cell Significance Index: -3.3200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2166
    Cell Significance Index: -3.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2823
    Cell Significance Index: -41.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2852
    Cell Significance Index: -19.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3870
    Cell Significance Index: -13.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4165
    Cell Significance Index: -87.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5028
    Cell Significance Index: -6.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5245
    Cell Significance Index: -11.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5580
    Cell Significance Index: -14.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5916
    Cell Significance Index: -24.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6090
    Cell Significance Index: -70.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6961
    Cell Significance Index: -72.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7096
    Cell Significance Index: -56.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7429
    Cell Significance Index: -6.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7531
    Cell Significance Index: -9.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7961
    Cell Significance Index: -44.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8358
    Cell Significance Index: -23.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8919
    Cell Significance Index: -21.3900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9467
    Cell Significance Index: -16.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0834
    Cell Significance Index: -34.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0996
    Cell Significance Index: -28.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.1532
    Cell Significance Index: -24.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1730
    Cell Significance Index: -40.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2690
    Cell Significance Index: -77.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2970
    Cell Significance Index: -28.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3746
    Cell Significance Index: -60.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.3961
    Cell Significance Index: -15.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4749
    Cell Significance Index: -22.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5447
    Cell Significance Index: -28.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5799
    Cell Significance Index: -59.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7861
    Cell Significance Index: -62.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.8085
    Cell Significance Index: -66.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.8121
    Cell Significance Index: -38.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8199
    Cell Significance Index: -18.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.8588
    Cell Significance Index: -59.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.8771
    Cell Significance Index: -61.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0152
    Cell Significance Index: -59.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.0872
    Cell Significance Index: -53.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Modulator**: TLE5 belongs to the TLE family, which has been implicated in regulating gene expression through interactions with transcription factors and chromatin-modifying complexes. 2. **Negative Regulation**: TLE5 has been shown to negatively regulate various signaling pathways, including the canonical Wnt signaling pathway, cytokine response, and transcription by RNA polymerase II. 3. **Cellular Localization**: TLE5 is predominantly expressed in immune cells, including T cells, B cells, and trophoblasts. 4. **Protein-Protein Interactions**: TLE5 interacts with various transcription factors and chromatin-modifying complexes, including the destruction complex, which degrades beta-catenin. **Pathways and Functions:** 1. **Wnt Signaling Pathway**: TLE5 negatively regulates the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Cytokine Response**: TLE5 negatively regulates the response to cytokines, which are essential for immune cell development and function. 3. **Transcriptional Regulation**: TLE5 acts as a transcriptional corepressor, regulating the expression of target genes involved in immune cell development and function. 4. **Cellular Response to Extracellular Stimuli**: TLE5 negatively regulates the cellular response to extracellular stimuli, including growth factors and cytokines. **Clinical Significance:** 1. **Immune Cell Development**: TLE5's involvement in immune cell development highlights its potential significance in immunology and disease. 2. **Cancer**: Aberrant expression of TLE5 has been implicated in various cancers, including leukemia and lymphoma. 3. **Autoimmune Diseases**: TLE5's role in regulating immune cell function may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Immunotherapy**: Understanding TLE5's function in immune cells may provide insights into the development of novel immunotherapies for cancer and autoimmune diseases. In conclusion, TLE5 is a transcriptional modulator that plays a critical role in regulating immune cell development and function. Its involvement in various signaling pathways and cellular processes highlights its potential significance in immunology and disease. Further research is needed to fully elucidate TLE5's function and its clinical significance.

Genular Protein ID: 2813430557

Symbol: TLE5_HUMAN

Name: Amino-terminal enhancer of split

UniProtKB Accession Codes:

Q08117 B2RBL0 Q12808 Q14CJ1 Q96TG9 Q9UDY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9809752

Title: Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein.

PubMed ID: 9809752

DOI: 10.1089/dna.1998.17.911

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8365415

Title: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

PubMed ID: 8365415

DOI: 10.1111/j.1432-1033.1993.tb18151.x

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 11390640

Title: Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.

PubMed ID: 11390640

DOI: 10.1128/mcb.21.13.4110-4118.2001

PubMed ID: 12441302

Title: Six3 and Six6 activity is modulated by members of the groucho family.

PubMed ID: 12441302

DOI: 10.1242/dev.00185

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

Sequence Information:

  • Length: 197
  • Mass: 21970
  • Checksum: 3851663AA6921A9F
  • Sequence:
    • MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH 
YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN 
SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK 
NGHDGDTHQE DDGEKSD

Genular Protein ID: 1555992136

Symbol: Q8WY48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WY48

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 3 SAM 1

Sequence Information:

  • Length: 103
  • Mass: 11192
  • Checksum: 5B4189E7EB29CEAA
  • Sequence:
    • MGDQVPREQD LAKRSSPGPS PVLNMCNRQS AWATALSPWY CMHAMLAAPF PSWAPRVSPD 
PGSQVCSHLH LPHSPPLLVP DTSTPTWSSP IAHKRGGTRD ELS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.