TLE5 | ENSG00000104964 | NCBI 166

Details for: TLE5

Gene ID: 166

Symbol: TLE5

Ensembl ID: ENSG00000104964

Description: TLE family member 5, transcriptional modulator

Associated with

Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Repression of wnt target genes
(R-HSA-4641265)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Cellular response to extracellular stimulus
(GO:0031668)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of response to cytokine stimulus
(GO:0060761)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Positive regulation of anoikis
(GO:2000210)
Protein binding
(GO:0005515)
Regulation of growth
(GO:0040008)
Response to interleukin-1
(GO:0070555)
Skeletal system development
(GO:0001501)
Transcription corepressor activity
(GO:0003714)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Amino-terminal enhancer of split
Q8WY48_HUMAN

Genular Protein ID: 2813430557

Symbol: TLE5_HUMAN

Name: Amino-terminal enhancer of split

UniProtKB Accession Codes:

Q08117 B2RBL0 Q12808 Q14CJ1 Q96TG9 Q9UDY9

Database IDs:

Citations:

PubMed ID: 9809752

Title: Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein.

PubMed ID: 9809752

DOI: 10.1089/dna.1998.17.911

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8365415

Title: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

PubMed ID: 8365415

DOI: 10.1111/j.1432-1033.1993.tb18151.x

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 11390640

Title: Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.

PubMed ID: 11390640

DOI: 10.1128/mcb.21.13.4110-4118.2001

PubMed ID: 12441302

Title: Six3 and Six6 activity is modulated by members of the groucho family.

PubMed ID: 12441302

DOI: 10.1242/dev.00185

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

Sequence Information:

Length: 197
Mass: 21970
Checksum: 3851663AA6921A9F
Sequence:

MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH 
YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN 
SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK 
NGHDGDTHQE DDGEKSD

Genular Protein ID: 1555992136

Symbol: Q8WY48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WY48

Database IDs:

Sequence Information:

Length: 103
Mass: 11192
Checksum: 5B4189E7EB29CEAA
Sequence:

MGDQVPREQD LAKRSSPGPS PVLNMCNRQS AWATALSPWY CMHAMLAAPF PSWAPRVSPD 
PGSQVCSHLH LPHSPPLLVP DTSTPTWSSP IAHKRGGTRD ELS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TLE5

Associated with

Other Information

Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein. PubMed ID: 9809752

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. PubMed ID: 8365415

Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. PubMed ID: 10660609

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. PubMed ID: 10748198

Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. PubMed ID: 11390640

Six3 and Six6 activity is modulated by members of the groucho family. PubMed ID: 12441302

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. PubMed ID: 22304967