Details for: TLE5

Gene ID: 166

Symbol: TLE5

Ensembl ID: ENSG00000104964

Description: TLE family member 5, transcriptional modulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 5.46
    Marker Score: 3,996
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 4.09
    Marker Score: 2,394
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.89
    Marker Score: 3,302
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.68
    Marker Score: 194,767
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.64
    Marker Score: 3,245
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.59
    Marker Score: 3,540
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.53
    Marker Score: 11,155
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.26
    Marker Score: 7,960
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.2
    Marker Score: 2,813
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.18
    Marker Score: 8,911
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.07
    Marker Score: 2,869
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.02
    Marker Score: 1,054
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.02
    Marker Score: 8,812
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.98
    Marker Score: 1,491
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.96
    Marker Score: 4,355
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.93
    Marker Score: 21,810
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.92
    Marker Score: 7,356
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.91
    Marker Score: 1,256
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.87
    Marker Score: 6,051
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.85
    Marker Score: 28,223
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.84
    Marker Score: 1,566
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.84
    Marker Score: 7,598
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.77
    Marker Score: 4,592
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.77
    Marker Score: 1,669
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.76
    Marker Score: 27,936
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.74
    Marker Score: 6,236
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.73
    Marker Score: 1,525
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.66
    Marker Score: 877
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.65
    Marker Score: 939
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.58
    Marker Score: 2,033
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.58
    Marker Score: 3,554
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.57
    Marker Score: 796
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.55
    Marker Score: 2,687
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 2.54
    Marker Score: 1,730
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.5
    Marker Score: 21,701
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.48
    Marker Score: 1,595
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.47
    Marker Score: 1,684
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.47
    Marker Score: 2,321
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.44
    Marker Score: 2,358
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.43
    Marker Score: 1,774
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.43
    Marker Score: 28,238
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.42
    Marker Score: 4,326
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.4
    Marker Score: 2,435
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.39
    Marker Score: 1,592
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.38
    Marker Score: 31,690
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.38
    Marker Score: 3,506
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.38
    Marker Score: 697
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.38
    Marker Score: 1,110
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.36
    Marker Score: 717
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.36
    Marker Score: 4,048
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.36
    Marker Score: 1,986
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.35
    Marker Score: 1,660
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.32
    Marker Score: 10,750
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.32
    Marker Score: 23,365
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.29
    Marker Score: 14,616
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.28
    Marker Score: 14,560
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.28
    Marker Score: 2,534
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.27
    Marker Score: 2,403
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.26
    Marker Score: 3,197
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.25
    Marker Score: 2,531
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.25
    Marker Score: 8,330
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.24
    Marker Score: 4,693
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.24
    Marker Score: 1,496
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.21
    Marker Score: 3,202
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.2
    Marker Score: 29,041
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.2
    Marker Score: 4,314
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.19
    Marker Score: 1,133
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.18
    Marker Score: 5,530
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.17
    Marker Score: 29,212
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.17
    Marker Score: 3,563
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.16
    Marker Score: 5,267
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.15
    Marker Score: 1,062
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.15
    Marker Score: 5,847
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.12
    Marker Score: 9,130
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.11
    Marker Score: 609
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.11
    Marker Score: 73,009
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.1
    Marker Score: 7,458
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.1
    Marker Score: 2,229
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.06
    Marker Score: 1,269
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.06
    Marker Score: 767
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.06
    Marker Score: 8,541
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.05
    Marker Score: 2,229
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.05
    Marker Score: 1,158
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.05
    Marker Score: 775
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.05
    Marker Score: 489
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.04
    Marker Score: 12,124
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.04
    Marker Score: 968
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.04
    Marker Score: 1,450
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.04
    Marker Score: 13,261
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.03
    Marker Score: 4,452
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.02
    Marker Score: 3,588
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.02
    Marker Score: 22,731
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.02
    Marker Score: 2,111
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.01
    Marker Score: 463
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.01
    Marker Score: 2,159
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2
    Marker Score: 2,160
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2
    Marker Score: 1,918
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2
    Marker Score: 2,072
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.98
    Marker Score: 1,163
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.98
    Marker Score: 1,891

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Modulator**: TLE5 belongs to the TLE family, which has been implicated in regulating gene expression through interactions with transcription factors and chromatin-modifying complexes. 2. **Negative Regulation**: TLE5 has been shown to negatively regulate various signaling pathways, including the canonical Wnt signaling pathway, cytokine response, and transcription by RNA polymerase II. 3. **Cellular Localization**: TLE5 is predominantly expressed in immune cells, including T cells, B cells, and trophoblasts. 4. **Protein-Protein Interactions**: TLE5 interacts with various transcription factors and chromatin-modifying complexes, including the destruction complex, which degrades beta-catenin. **Pathways and Functions:** 1. **Wnt Signaling Pathway**: TLE5 negatively regulates the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Cytokine Response**: TLE5 negatively regulates the response to cytokines, which are essential for immune cell development and function. 3. **Transcriptional Regulation**: TLE5 acts as a transcriptional corepressor, regulating the expression of target genes involved in immune cell development and function. 4. **Cellular Response to Extracellular Stimuli**: TLE5 negatively regulates the cellular response to extracellular stimuli, including growth factors and cytokines. **Clinical Significance:** 1. **Immune Cell Development**: TLE5's involvement in immune cell development highlights its potential significance in immunology and disease. 2. **Cancer**: Aberrant expression of TLE5 has been implicated in various cancers, including leukemia and lymphoma. 3. **Autoimmune Diseases**: TLE5's role in regulating immune cell function may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Immunotherapy**: Understanding TLE5's function in immune cells may provide insights into the development of novel immunotherapies for cancer and autoimmune diseases. In conclusion, TLE5 is a transcriptional modulator that plays a critical role in regulating immune cell development and function. Its involvement in various signaling pathways and cellular processes highlights its potential significance in immunology and disease. Further research is needed to fully elucidate TLE5's function and its clinical significance.

Genular Protein ID: 2813430557

Symbol: TLE5_HUMAN

Name: Amino-terminal enhancer of split

UniProtKB Accession Codes:

Q08117 B2RBL0 Q12808 Q14CJ1 Q96TG9 Q9UDY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9809752

Title: Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein.

PubMed ID: 9809752

DOI: 10.1089/dna.1998.17.911

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8365415

Title: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

PubMed ID: 8365415

DOI: 10.1111/j.1432-1033.1993.tb18151.x

PubMed ID: 10660609

Title: Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats.

PubMed ID: 10660609

DOI: 10.1074/jbc.275.6.4383

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 11390640

Title: Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.

PubMed ID: 11390640

DOI: 10.1128/mcb.21.13.4110-4118.2001

PubMed ID: 12441302

Title: Six3 and Six6 activity is modulated by members of the groucho family.

PubMed ID: 12441302

DOI: 10.1242/dev.00185

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

Sequence Information:

  • Length: 197
  • Mass: 21970
  • Checksum: 3851663AA6921A9F
  • Sequence:
    • MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH 
YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN 
SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK 
NGHDGDTHQE DDGEKSD

Genular Protein ID: 1555992136

Symbol: Q8WY48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WY48

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 3 SAM 1

Sequence Information:

  • Length: 103
  • Mass: 11192
  • Checksum: 5B4189E7EB29CEAA
  • Sequence:
    • MGDQVPREQD LAKRSSPGPS PVLNMCNRQS AWATALSPWY CMHAMLAAPF PSWAPRVSPD 
PGSQVCSHLH LPHSPPLLVP DTSTPTWSSP IAHKRGGTRD ELS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.