Details for: Klf4

Gene ID: 16600

Symbol: Klf4

Ensembl ID: ENSMUSG00000003032

Description: Kruppel-like transcription factor 4 (gut)

Associated with

  • Beta-catenin binding
    (GO:0008013)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Chromatin
    (GO:0000785)
  • Chromatin dna binding
    (GO:0031490)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Defense response to tumor cell
    (GO:0002357)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Epidermal cell differentiation
    (GO:0009913)
  • Epidermis development
    (GO:0008544)
  • Epidermis morphogenesis
    (GO:0048730)
  • Establishment of skin barrier
    (GO:0061436)
  • Euchromatin
    (GO:0000791)
  • Fat cell differentiation
    (GO:0045444)
  • Gene expression
    (GO:0010467)
  • Glandular epithelial cell differentiation
    (GO:0002067)
  • Histone deacetylase binding
    (GO:0042826)
  • Metal ion binding
    (GO:0046872)
  • Microtubule cytoskeleton
    (GO:0015630)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000342)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of leukocyte adhesion to arterial endothelial cell
    (GO:1904998)
  • Negative regulation of muscle hyperplasia
    (GO:0014740)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of response to cytokine stimulus
    (GO:0060761)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Phosphatidylinositol 3-kinase regulator activity
    (GO:0035014)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of hemoglobin biosynthetic process
    (GO:0046985)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of telomerase activity
    (GO:0051973)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-embryonic camera-type eye development
    (GO:0031077)
  • Post-embryonic hemopoiesis
    (GO:0035166)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Regulation of axon regeneration
    (GO:0048679)
  • Regulation of blastocyst development
    (GO:0120222)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to organic substance
    (GO:0010033)
  • Response to retinoic acid
    (GO:0032526)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii sequence-specific dna-binding transcription factor recruiting activity
    (GO:0001010)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stem cell population maintenance
    (GO:0019827)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 3085992639

Symbol: KLF4_MOUSE

Name: Krueppel-like factor 4

UniProtKB Accession Codes:

Q60793 P70421 Q3U2D6 Q3URS6 Q78K30 Q9R255

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 ELM 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 9 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8702718

Title: Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest.

PubMed ID: 8702718

DOI: 10.1074/jbc.271.33.20009

PubMed ID: 8940147

Title: A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells.

PubMed ID: 8940147

DOI: 10.1074/jbc.271.49.31384

PubMed ID: 10556311

Title: Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4).

PubMed ID: 10556311

DOI: 10.1093/nar/27.23.4562

PubMed ID: 12441126

Title: STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression.

PubMed ID: 12441126

DOI: 10.1006/excr.2002.5633

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10431239

Title: Klf4 is a transcription factor required for establishing the barrier function of the skin.

PubMed ID: 10431239

DOI: 10.1038/11926

PubMed ID: 15358627

Title: Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.

PubMed ID: 15358627

DOI: 10.1182/blood-2004-07-2681

PubMed ID: 16904174

Title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

PubMed ID: 16904174

DOI: 10.1016/j.cell.2006.07.024

PubMed ID: 16954384

Title: Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells.

PubMed ID: 16954384

DOI: 10.1128/mcb.00468-06

PubMed ID: 17060454

Title: Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.

PubMed ID: 17060454

DOI: 10.1128/mcb.00846-06

PubMed ID: 19816951

Title: Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.

PubMed ID: 19816951

DOI: 10.1002/stem.231

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20071344

Title: Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression.

PubMed ID: 20071344

DOI: 10.1074/jbc.m109.077958

PubMed ID: 24161396

Title: Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator.

PubMed ID: 24161396

DOI: 10.1016/j.bbrc.2013.10.073

PubMed ID: 29593216

Title: Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

PubMed ID: 29593216

DOI: 10.1038/s41467-018-03008-2

PubMed ID: 35922041

Title: IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.

PubMed ID: 35922041

DOI: 10.1093/stmcls/sxac055

Sequence Information:

  • Length: 483
  • Mass: 51880
  • Checksum: 5D1B0BF7948C49B3
  • Sequence:
    • MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRPAGAP TNRWREELSH MKRLPPLPGR 
PYDLAATVAT DLESGGAGAA CSSNNPALLA RRETEEFNDL LDLDFILSNS LTHQESVAAT 
VTTSASASSS SSPASSGPAS APSTCSFSYP IRAGGDPGVA ASNTGGGLLY SRESAPPPTA 
PFNLADINDV SPSGGFVAEL LRPELDPVYI PPQQPQPPGG GLMGKFVLKA SLTTPGSEYS 
SPSVISVSKG SPDGSHPVVV APYSGGPPRM CPKIKQEAVP SCTVSRSLEA HLSAGPQLSN 
GHRPNTHDFP LGRQLPTRTT PTLSPEELLN SRDCHPGLPL PPGFHPHPGP NYPPFLPDQM 
QSQVPSLHYQ ELMPPGSCLP EEPKPKRGRR SWPRKRTATH TCDYAGCGKT YTKSSHLKAH 
LRTHTGEKPY HCDWDGCGWK FARSDELTRH YRKHTGHRPF QCQKCDRAFS RSDHLALHMK 
RHF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.