Kpna2 | ENSMUSG00000018362 | NCBI 16647

Details for: Kpna2

Gene ID: 16647

Symbol: Kpna2

Ensembl ID: ENSMUSG00000018362

Description: karyopherin subunit alpha 2

Associated with

Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Dna repair
(R-MMU-73894)
Sensing of dna double strand breaks
(R-MMU-5693548)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Entry of viral genome into host nucleus through nuclear pore complex via importin
(GO:0075506)
Glutamatergic synapse
(GO:0098978)
Histone deacetylase binding
(GO:0042826)
Nls-bearing protein import into nucleus
(GO:0006607)
Nls-dependent protein nuclear import complex
(GO:0042564)
Nuclear import signal receptor activity
(GO:0061608)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of viral life cycle
(GO:1903902)
Postsynapse to nucleus signaling pathway
(GO:0099527)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)

Other Information

Proteins

Importin alpha P1

Genular Protein ID: 2775919474

Symbol: IMA1_MOUSE

Name: Importin alpha P1

UniProtKB Accession Codes:

P52293 Q64292

Database IDs:

Citations:

PubMed ID: 7641681

Title: In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import.

PubMed ID: 7641681

DOI: 10.1002/j.1460-2075.1995.tb00031.x

PubMed ID: 7565597

Title: Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis.

PubMed ID: 7565597

DOI: 10.1007/bf02191602

PubMed ID: 8631802

Title: The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins.

PubMed ID: 8631802

DOI: 10.1074/jbc.271.13.7654

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10692581

Title: Characterization of the nuclear transport of a novel leucine-rich acidic nuclear protein-like protein.

PubMed ID: 10692581

DOI: 10.1016/s0014-5793(00)01218-7

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21454664

Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.

PubMed ID: 21454664

DOI: 10.1074/jbc.m110.213579

PubMed ID: 26689472

Title: Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

PubMed ID: 26689472

DOI: 10.1016/j.freeradbiomed.2015.12.002

PubMed ID: 10764582

Title: Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.

PubMed ID: 10764582

DOI: 10.1006/jmbi.2000.3642

PubMed ID: 10201409

Title: Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.

PubMed ID: 10201409

DOI: 10.1038/7625

PubMed ID: 11448961

Title: Biophysical characterization of interactions involving importin-alpha during nuclear import.

PubMed ID: 11448961

DOI: 10.1074/jbc.m103531200

PubMed ID: 16222336

Title: Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling.

PubMed ID: 16222336

DOI: 10.1038/sj.emboj.7600843

Sequence Information:

Length: 529
Mass: 57928
Checksum: 19E64AA3E9C3C7B5
Sequence:

MSTNENANLP AARLNRFKNK GKDSTEMRRR RIEVNVELRK AKKDEQMLKR RNVSSFPDDA 
TSPLQENRNN QGTVNWSVED IVKGINSNNL ESQLQATQAA RKLLSREKQP PIDNIIRAGL 
IPKFVSFLGK TDCSPIQFES AWALTNIASG TSEQTKAVVD GGAIPAFISL LASPHAHISE 
QAVWALGNIA GDGSAFRDLV IKHGAIDPLL ALLAVPDLST LACGYLRNLT WTLSNLCRNK 
NPAPPLDAVE QILPTLVRLL HHNDPEVLAD SCWAISYLTD GPNERIEMVV KKGVVPQLVK 
LLGATELPIV TPALRAIGNI VTGTDEQTQK VIDAGALAVF PSLLTNPKTN IQKEATWTMS 
NITAGRQDQI QQVVNHGLVP FLVGVLSKAD FKTQKEAAWA ITNYTSGGTV EQIVYLVHCG 
IIEPLMNLLS AKDTKIIQVI LDAISNIFQA AEKLGETEKL SIMIEECGGL DKIEALQRHE 
NESVYKASLN LIEKYFSVEE EEDQNVVPET TSEGFAFQVQ DGAPGTFNF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kpna2

Associated with

Other Information

In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. PubMed ID: 7641681

Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis. PubMed ID: 7565597

The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. PubMed ID: 8631802

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the nuclear transport of a novel leucine-rich acidic nuclear protein-like protein. PubMed ID: 10692581

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Importin alpha protein acts as a negative regulator for Snail protein nuclear import. PubMed ID: 21454664

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. PubMed ID: 26689472

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. PubMed ID: 10764582

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. PubMed ID: 10201409

Biophysical characterization of interactions involving importin-alpha during nuclear import. PubMed ID: 11448961

Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. PubMed ID: 16222336