Genular: Defining Cellular Identity and Function

Details for: Mafb

Gene ID: 16658

Symbol: Mafb

Ensembl ID: ENSMUSG00000074622

Description: MAF bZIP transcription factor B

Associated with

Abducens nerve formation
(GO:0021599)
Brain segmentation
(GO:0035284)
Cornified envelope assembly
(GO:1903575)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Identical protein binding
(GO:0042802)
Inner ear morphogenesis
(GO:0042472)
Keratinocyte differentiation
(GO:0030216)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of osteoclast differentiation
(GO:0045671)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of myeloid cell differentiation
(GO:0045637)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Rhombomere 5 development
(GO:0021571)
Rhombomere 6 development
(GO:0021572)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Segment specification
(GO:0007379)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
T cell differentiation in thymus
(GO:0033077)
Thymus development
(GO:0048538)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Transcription factor MafB

Genular Protein ID: 1419298578

Symbol: MAFB_MOUSE

Name: Transcription factor MafB

UniProtKB Accession Codes:

P54841 Q3U3C8 Q3UPT9

Database IDs:

Citations:

PubMed ID: 8001130

Title: The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.

PubMed ID: 8001130

DOI: 10.1016/0092-8674(94)90033-7

PubMed ID: 10721736

Title: Molecular cloning and functional characterization of the mouse mafB gene.

PubMed ID: 10721736

DOI: 10.1016/s0378-1119(99)00500-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10383433

Title: Regulation of lens fiber cell differentiation by transcription factor c-Maf.

PubMed ID: 10383433

DOI: 10.1074/jbc.274.27.19254

PubMed ID: 10790365

Title: MafB is an inducer of monocytic differentiation.

PubMed ID: 10790365

DOI: 10.1093/emboj/19.9.1987

PubMed ID: 11823429

Title: Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.

PubMed ID: 11823429

DOI: 10.1093/emboj/21.3.365

PubMed ID: 14513037

Title: MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth.

PubMed ID: 14513037

DOI: 10.1038/nn1129

PubMed ID: 15135046

Title: Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.

PubMed ID: 15135046

DOI: 10.1016/j.febslet.2004.03.069

PubMed ID: 16443760

Title: MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

PubMed ID: 16443760

DOI: 10.2337/diabetes.55.02.06.db05-0946

PubMed ID: 16847325

Title: MafB is essential for renal development and F4/80 expression in macrophages.

PubMed ID: 16847325

DOI: 10.1128/mcb.00001-06

PubMed ID: 16943423

Title: Development of macrophages with altered actin organization in the absence of MafB.

PubMed ID: 16943423

DOI: 10.1128/mcb.00245-06

PubMed ID: 17901057

Title: Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.

PubMed ID: 17901057

DOI: 10.1074/jbc.m702795200

PubMed ID: 17548468

Title: SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression.

PubMed ID: 17548468

DOI: 10.1128/mcb.01811-06

PubMed ID: 17360442

Title: MafB is required for islet beta cell maturation.

PubMed ID: 17360442

DOI: 10.1073/pnas.0700013104

PubMed ID: 18199433

Title: Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

PubMed ID: 18199433

DOI: 10.1016/j.ydbio.2007.12.009

PubMed ID: 17977745

Title: Math5 expression and function in the central auditory system.

PubMed ID: 17977745

DOI: 10.1016/j.mcn.2007.09.006

PubMed ID: 19143053

Title: A new MAFia in cancer.

PubMed ID: 19143053

DOI: 10.1038/nrc2460

PubMed ID: 19440205

Title: Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.

PubMed ID: 19440205

DOI: 10.1038/emboj.2009.127

PubMed ID: 27181683

Title: Loss of MAFB function in humans and mice causes Duane syndrome, aberrant extraocular muscle innervation, and inner-ear defects.

PubMed ID: 27181683

DOI: 10.1016/j.ajhg.2016.03.023

Sequence Information:

Length: 323
Mass: 35809
Checksum: D77AE07ABD9C2AD2
Sequence:

MAAELSMGQE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL 
STPCSSVPSS PSFSPTEPKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP 
LQSFDGFRSA HHHHHHHHPH PHHGYPGAGV THDDLGQHAH PHHHHHHQAS PPPSSAASPA 
QQLPTSHPGP GPHATAAATA AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK 
QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK 
LANSGFREAG STSDSPSSPE FFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mafb

Associated with

Other Information

The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. PubMed ID: 8001130

Molecular cloning and functional characterization of the mouse mafB gene. PubMed ID: 10721736

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of lens fiber cell differentiation by transcription factor c-Maf. PubMed ID: 10383433

MafB is an inducer of monocytic differentiation. PubMed ID: 10790365

Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. PubMed ID: 11823429

MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. PubMed ID: 14513037

Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. PubMed ID: 15135046

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. PubMed ID: 16443760

MafB is essential for renal development and F4/80 expression in macrophages. PubMed ID: 16847325

Development of macrophages with altered actin organization in the absence of MafB. PubMed ID: 16943423

Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. PubMed ID: 17901057

SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression. PubMed ID: 17548468

MafB is required for islet beta cell maturation. PubMed ID: 17360442

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. PubMed ID: 18199433

Math5 expression and function in the central auditory system. PubMed ID: 17977745

A new MAFia in cancer. PubMed ID: 19143053

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. PubMed ID: 19440205

Loss of MAFB function in humans and mice causes Duane syndrome, aberrant extraocular muscle innervation, and inner-ear defects. PubMed ID: 27181683