Genular: Defining Cellular Identity and Function

Details for: Krt18

Gene ID: 16668

Symbol: Krt18

Ensembl ID: ENSMUSG00000023043

Description: keratin 18

Associated with

Developmental biology
(R-MMU-1266738)
Formation of the cornified envelope
(R-MMU-6809371)
Keratinization
(R-MMU-6805567)
Cell periphery
(GO:0071944)
Centriolar satellite
(GO:0034451)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Golgi to plasma membrane protein transport
(GO:0043001)
Hepatocyte apoptotic process
(GO:0097284)
Intermediate filament
(GO:0005882)
Intermediate filament cytoskeleton organization
(GO:0045104)
Keratin filament
(GO:0045095)
Microtubule organizing center
(GO:0005815)
Negative regulation of apoptotic process
(GO:0043066)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Scaffold protein binding
(GO:0097110)
Structural molecule activity
(GO:0005198)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Other Information

Proteins

Keratin, type I cytoskeletal 18

Genular Protein ID: 2346819833

Symbol: K1C18_MOUSE

Name: Keratin, type I cytoskeletal 18

UniProtKB Accession Codes:

P05784 Q3TIX1 Q3TJH6 Q3TJW7 Q61766

Database IDs:

Citations:

PubMed ID: 2416755

Title: Molecular cloning and characterization of the Endo B cytokeratin expressed in preimplantation mouse embryos.

PubMed ID: 2416755

DOI: 10.1016/s0021-9258(17)36125-2

PubMed ID: 2467843

Title: Nucleotide sequence and structure of the mouse cytokeratin endoB gene.

PubMed ID: 2467843

DOI: 10.1016/0378-1119(88)90107-2

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2454868

Title: Identification of the gene coding for the Endo B murine cytokeratin and its methylated, stable inactive state in mouse nonepithelial cells.

PubMed ID: 2454868

DOI: 10.1101/gad.2.5.505

PubMed ID: 7504637

Title: Embryonic expression of human keratin 18 and K18-beta-galactosidase fusion genes in transgenic mice.

PubMed ID: 7504637

DOI: 10.1006/dbio.1993.1326

PubMed ID: 7507912

Title: Monoclonal antibodies recognising stage and region specific epitopes in embryonic mouse palatal epithelial cells.

PubMed ID: 7507912

PubMed ID: 9298992

Title: Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.

PubMed ID: 9298992

DOI: 10.1083/jcb.138.6.1379

PubMed ID: 16973199

Title: Superficial cell differentiation during embryonic and postnatal development of mouse urothelium.

PubMed ID: 16973199

DOI: 10.1016/j.tice.2006.07.001

PubMed ID: 17213200

Title: Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations.

PubMed ID: 17213200

DOI: 10.1074/jbc.m604068200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20724476

Title: p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

PubMed ID: 20724476

DOI: 10.1074/jbc.m110.132357

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 25617501

Title: Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.

PubMed ID: 25617501

DOI: 10.1016/j.jhep.2015.01.007

Sequence Information:

Length: 423
Mass: 47538
Checksum: A67ACD6814A02118
Sequence:

MSFTTRSTTF STNYRSLGSV RTPSQRVRPA SSAASVYAGA GGSGSRISVS RSVWGGSVGS 
AGLAGMGGIQ TEKETMQDLN DRLASYLDKV KSLETENRRL ESKIREHLEK KGPQGVRDWG 
HYFKIIEDLR AQIFANSVDN ARIVLQIDNA RLAADDFRVK YETELAMRQS VESDIHGLRK 
VVDDTNITRL QLETEIEALK EELLFMKKNH EEEVQGLEAQ IASSGLTVEV DAPKSQDLSK 
IMADIRAQYE ALAQKNREEL DKYWSQQIEE STTVVTTKSA EIRDAETTLT ELRRTLQTLE 
IDLDSMKNQN INLENSLGDV EARYKAQMEQ LNGVLLHLES ELAQTRAEGQ RQAQEYEALL 
NIKVKLEAEI ATYRRLLEDG EDFSLNDALD SSNSMQTVQK TTTRKIVDGR VVSETNDTRV 
LRH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Krt18

Associated with

Other Information

Molecular cloning and characterization of the Endo B cytokeratin expressed in preimplantation mouse embryos. PubMed ID: 2416755

Nucleotide sequence and structure of the mouse cytokeratin endoB gene. PubMed ID: 2467843

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the gene coding for the Endo B murine cytokeratin and its methylated, stable inactive state in mouse nonepithelial cells. PubMed ID: 2454868

Embryonic expression of human keratin 18 and K18-beta-galactosidase fusion genes in transgenic mice. PubMed ID: 7504637

Monoclonal antibodies recognising stage and region specific epitopes in embryonic mouse palatal epithelial cells. PubMed ID: 7507912

Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. PubMed ID: 9298992

Superficial cell differentiation during embryonic and postnatal development of mouse urothelium. PubMed ID: 16973199

Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations. PubMed ID: 17213200

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. PubMed ID: 20724476

Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure. PubMed ID: 24940650

Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization. PubMed ID: 25617501