Genular: Defining Cellular Identity and Function

Details for: Krt1

Gene ID: 16678

Symbol: Krt1

Ensembl ID: ENSMUSG00000046834

Description: keratin 1

Associated with

Developmental biology
(R-MMU-1266738)
Formation of the cornified envelope
(R-MMU-6809371)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Carbohydrate binding
(GO:0030246)
Collagen-containing extracellular matrix
(GO:0062023)
Complement activation, lectin pathway
(GO:0001867)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Establishment of skin barrier
(GO:0061436)
Intermediate filament
(GO:0005882)
Intermediate filament organization
(GO:0045109)
Keratin filament
(GO:0045095)
Keratinization
(GO:0031424)
Membrane
(GO:0016020)
Negative regulation of inflammatory response
(GO:0050728)
Peptide cross-linking
(GO:0018149)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein heterotetramerization
(GO:0051290)
Structural constituent of skin epidermis
(GO:0030280)

Other Information

Proteins

Keratin, type II cytoskeletal 1

Genular Protein ID: 1120982032

Symbol: K2C1_MOUSE

Name: Keratin, type II cytoskeletal 1

UniProtKB Accession Codes:

P04104 Q149E0 Q9D2K8

Database IDs:

Citations:

PubMed ID: 2581964

Title: Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits.

PubMed ID: 2581964

DOI: 10.1016/s0021-9258(18)88900-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11408584

Title: Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex.

PubMed ID: 11408584

DOI: 10.1091/mbc.12.6.1775

PubMed ID: 11841545

Title: Sequential reorganization of cornified cell keratin filaments involving filaggrin-mediated compaction and keratin 1 deimination.

PubMed ID: 11841545

DOI: 10.1046/j.0022-202x.2001.01671.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24751727

Title: Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.

PubMed ID: 24751727

DOI: 10.1038/jid.2014.197

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 16528356

Title: A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis.

PubMed ID: 16528356

DOI: 10.1038/sj.jid.5700241

Sequence Information:

Length: 637
Mass: 65606
Checksum: D2016D15066FD0A5
Sequence:

MSLQCSSRSL CRGGGGSRNF SSGSAGLVSF QRRSTSSSMR RSGGGGGGRF SGGGFCGSSG 
SGFGSKSLMN LGGGRSISKS VAGGGGSFCG GFGGGSYGGG GFGGGSYGGG GFGGGSFGGG 
GFGGSGFGGG LGGGGGFGSG GGFGGGRFGS MGPVCPPGGI QEVTINQSLL QPLNVEVDPQ 
IQKVKSQERE QIKSLNDKFA SFIDKVRFLE QQNQVLQTKW ELLQQVDTTT RTQNLDPFFE 
NYISILRRKV DSLKSDQSRM DSELKNMQDL VEEYRTKYED EINKRTNAEN EFVTIKKDVD 
SAYMTKVELQ AKADALQQDI DFFSALYQME MSQMQTQISE TNVVLSMDNN RSLDLDGIIS 
EVKAQYDSIC QRSKAEAETF YQSKYEELQI TAGKHGDSVR NTKMEISELN RMIQRLRSEI 
DGCKKQISQI QQNINDAEQR GEKALKDAQN KLNEIEDALS QCKEDLARLL RDFQELMNTK 
LALDMEIATY KKLLEGEEIR MSGECTPNVS VSVSTSHTSM SGSSSRGGGS GGGRYGGGGS 
YGGGSGGGSY GGSSGGGGSG GSYGGGSGGG SYGGGSGGGS SGSHRGGSGG GGGSSGGSYG 
GSSGGGRGGS SSGGGGVKSS GSSTVKFVST SYSRGTK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Krt1

Associated with

Other Information

Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits. PubMed ID: 2581964

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. PubMed ID: 11408584

Sequential reorganization of cornified cell keratin filaments involving filaggrin-mediated compaction and keratin 1 deimination. PubMed ID: 11841545

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. PubMed ID: 24751727

Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure. PubMed ID: 24940650

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis. PubMed ID: 16528356