Genular: Defining Cellular Identity and Function

Details for: Krt8

Gene ID: 16691

Symbol: Krt8

Ensembl ID: ENSMUSG00000049382

Description: keratin 8

Associated with

Developmental biology
(R-MMU-1266738)
Formation of the cornified envelope
(R-MMU-6809371)
Keratinization
(R-MMU-6805567)
Apicolateral plasma membrane
(GO:0016327)
Cell-cell junction
(GO:0005911)
Cell differentiation involved in embryonic placenta development
(GO:0060706)
Cell periphery
(GO:0071944)
Costamere
(GO:0043034)
Cytoplasm
(GO:0005737)
Dystrophin-associated glycoprotein complex
(GO:0016010)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Hepatocyte apoptotic process
(GO:0097284)
Intermediate filament
(GO:0005882)
Intermediate filament cytoskeleton
(GO:0045111)
Keratin filament
(GO:0045095)
Nucleus
(GO:0005634)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Response to hydrostatic pressure
(GO:0051599)
Response to other organism
(GO:0051707)
Sarcolemma
(GO:0042383)
Sarcomere organization
(GO:0045214)
Scaffold protein binding
(GO:0097110)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Z disc
(GO:0030018)

Other Information

Proteins

Keratin, type II cytoskeletal 8

Genular Protein ID: 954878376

Symbol: K2C8_MOUSE

Name: Keratin, type II cytoskeletal 8

UniProtKB Accession Codes:

P11679 Q3KQK5 Q3TGI1 Q3TJE1 Q3TKY7 Q61463 Q61518 Q61519

Database IDs:

Citations:

PubMed ID: 2454862

Title: Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells.

PubMed ID: 2454862

DOI: 10.1111/j.1432-0436.1988.tb00794.x

PubMed ID: 2464527

Title: Nucleotide sequence of mouse EndoA cytokeratin cDNA reveals polypeptide characteristics of the type-II keratin subfamily.

PubMed ID: 2464527

DOI: 10.1016/0378-1119(88)90604-x

PubMed ID: 2467842

Title: Complete sequence of the mouse type-II keratin EndoA: its amino-terminal region resembles mitochondrial signal peptides.

PubMed ID: 2467842

DOI: 10.1016/0378-1119(88)90106-0

PubMed ID: 1717348

Title: Sequence of the EndoA gene encoding mouse cytokeratin and its methylation state in the CpG-rich region.

PubMed ID: 1717348

DOI: 10.1016/0378-1119(91)90247-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12857878

Title: Keratin 20 helps maintain intermediate filament organization in intestinal epithelia.

PubMed ID: 12857878

DOI: 10.1091/mbc.e03-02-0059

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20724476

Title: p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

PubMed ID: 20724476

DOI: 10.1074/jbc.m110.132357

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 25617501

Title: Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.

PubMed ID: 25617501

DOI: 10.1016/j.jhep.2015.01.007

Sequence Information:

Length: 490
Mass: 54565
Checksum: C0C79590F0C28502
Sequence:

MSIRVTQKSY KMSTSGPRAF SSRSFTSGPG ARISSSSFSR VGSSSSSFRG SMGTGVGLGG 
FGGAGVGGIT AVTVNQSLLS PLKLEVDPNI QAVRTQEKEQ IKSLNNKFAS FIDKVRFLEQ 
QNKMLETKWS LLQQQKTSRS NMDNMFESYI NNLRRQLEAL GQEKLKLEAE LGNMQGLVED 
FKNKYEDEIN KRTEMENEFV LIKKDVDEAY MNKVELESRL EGLTDEINFL RQIHEEEIRE 
LQSQISDTSV VLSMDNSRSL DMDGIIAEVR AQYEDIANRS RAEAETMYQI KYEELQTLAG 
KHGDDLRRTK TEISEMNRNI NRLQAEIEAL KGQRASLEAA IADAEQRGEM AIKDAQTKLA 
ELEAALQRAK QDMARQLREY QELMNVKLAL DIEITTYRKL LEGEESRLES GMQNMSIHTK 
TTSGYSGGLS SSYGGLTSPG FSYGMSSFQP GFGSAGGSNT FSRTTKAVVV KKIETRDGKL 
VSESSDVVSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Krt8

Associated with

Other Information

Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells. PubMed ID: 2454862

Nucleotide sequence of mouse EndoA cytokeratin cDNA reveals polypeptide characteristics of the type-II keratin subfamily. PubMed ID: 2464527

Complete sequence of the mouse type-II keratin EndoA: its amino-terminal region resembles mitochondrial signal peptides. PubMed ID: 2467842

Sequence of the EndoA gene encoding mouse cytokeratin and its methylation state in the CpG-rich region. PubMed ID: 1717348

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. PubMed ID: 12857878

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. PubMed ID: 20724476

Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure. PubMed ID: 24940650

Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization. PubMed ID: 25617501