Details for: CRISP1

Gene ID: 167

Symbol: CRISP1

Ensembl ID: ENSG00000124812

Description: cysteine rich secretory protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.17
    Marker Score: 3971
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 6.28
    Marker Score: 8665.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.16
    Marker Score: 2928
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.49
    Marker Score: 2363
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3176
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.47
    Marker Score: 1034
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.05
    Marker Score: 1354
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 1999
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.97
    Marker Score: 2205
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7494
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1515
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.72
    Marker Score: 1496
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 512
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1279
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.61
    Marker Score: 358
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9373.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 333
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.55
    Marker Score: 876
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.34
    Marker Score: 256
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.27
    Marker Score: 304
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 302
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 122
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.25
    Marker Score: 135
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.25
    Marker Score: 424
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.23
    Marker Score: 553.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 179
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 117
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 95
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.11
    Marker Score: 677
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 181.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.09
    Marker Score: 257
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 997
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 25.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 82
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.03
    Marker Score: 21

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * CRISP1 is a transmembrane protein with a predicted molecular weight of approximately 140 kDa. * It is a cysteine-rich protein that contains a conserved cysteine-rich domain. * CRISP1 is expressed in high levels in the testes of mice and humans. **Pathways and functions:** * CRISP1 is involved in the binding of sperm to the zona pellucida, the outer membrane of the egg. * It also plays a role in the regulation of calcium channel activity, which is essential for sperm penetration of the zona pellucida. * CRISP1 is involved in the fusion of sperm to the egg plasma membrane involved in single fertilization. * It is also involved in the regulation of acrosome reaction, which is the first step in fertilization. **Clinical significance:** * Mutations in the CRISP1 gene have been linked to male infertility in humans. * CRISP1 is a potential target for the treatment of male infertility. **Additional information:** * CRISP1 is a member of the cysteine-rich secretory protein family. * It is expressed in high levels in the testes of mice and humans. * It is a key regulator of sperm-egg interactions and fertilization.

Genular Protein ID: 2059426742

Symbol: CRIS1_HUMAN

Name: Cysteine-rich secretory protein 1

UniProtKB Accession Codes:

P54107 B5BU98 O00698 Q13248 Q14082 Q96SF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8665901

Title: The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.

PubMed ID: 8665901

DOI: 10.1111/j.1432-1033.1996.t01-1-00827.x

PubMed ID: 8543280

Title: Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization.

PubMed ID: 8543280

PubMed ID: 8838800

Title: Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1).

PubMed ID: 8838800

DOI: 10.1006/geno.1996.0131

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 249
  • Mass: 28481
  • Checksum: 85BED3DDEAD62A9C
  • Sequence:
    • MEIKHLLFLV AAACLLPMLS MKKKSARDQF NKLVTDLPNV QEEIVNIHNA LRRRVVPPAS 
NMLKMSWSEE AAQNARIFSK YCDMTESNPL ERRLPNTFCG ENMHMTSYPV SWSSVIGVWY 
SESTSFKHGE WTTTDDDITT DHYTQIVWAT SYLIGCAIAS CRQQGSPRYL YVCHYCHEGN 
DPETKNEPYK TGVPCEACPS NCEDKLCTNP CIYYDEYFDC DIQVHYLGCN HSTTILFCKA 
TCLCDTEIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.