Details for: CRISP1

Gene ID: 167

Symbol: CRISP1

Ensembl ID: ENSG00000124812

Description: cysteine rich secretory protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 11.4524
    Cell Significance Index: 195.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 8.4731
    Cell Significance Index: 109.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.6329
    Cell Significance Index: 222.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3815
    Cell Significance Index: 51.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4888
    Cell Significance Index: 47.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4726
    Cell Significance Index: 35.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3877
    Cell Significance Index: 62.9000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.3466
    Cell Significance Index: 14.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0347
    Cell Significance Index: 196.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7420
    Cell Significance Index: 73.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6557
    Cell Significance Index: 9.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6102
    Cell Significance Index: 13.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5941
    Cell Significance Index: 536.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4343
    Cell Significance Index: 6.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4174
    Cell Significance Index: 45.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3874
    Cell Significance Index: 63.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3147
    Cell Significance Index: 18.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2406
    Cell Significance Index: 6.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2261
    Cell Significance Index: 15.6400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1519
    Cell Significance Index: 1.7200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1462
    Cell Significance Index: 1.8500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1240
    Cell Significance Index: 1.7000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1124
    Cell Significance Index: 1.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0743
    Cell Significance Index: 1.2500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0670
    Cell Significance Index: 0.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0646
    Cell Significance Index: 1.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0480
    Cell Significance Index: 1.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0442
    Cell Significance Index: 2.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0347
    Cell Significance Index: 1.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0290
    Cell Significance Index: 0.4700
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.0262
    Cell Significance Index: 0.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0199
    Cell Significance Index: 0.5000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0036
    Cell Significance Index: 0.0500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0015
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0022
    Cell Significance Index: -0.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0025
    Cell Significance Index: -0.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0041
    Cell Significance Index: -0.7400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0041
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0048
    Cell Significance Index: -0.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0051
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0069
    Cell Significance Index: -0.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0076
    Cell Significance Index: -0.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0079
    Cell Significance Index: -0.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0083
    Cell Significance Index: -0.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0086
    Cell Significance Index: -0.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0100
    Cell Significance Index: -1.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0122
    Cell Significance Index: -0.7500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0145
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0191
    Cell Significance Index: -0.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0192
    Cell Significance Index: -0.2900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0193
    Cell Significance Index: -0.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0194
    Cell Significance Index: -0.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0195
    Cell Significance Index: -0.8000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0206
    Cell Significance Index: -0.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0209
    Cell Significance Index: -0.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0227
    Cell Significance Index: -1.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0234
    Cell Significance Index: -0.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0242
    Cell Significance Index: -1.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0253
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0260
    Cell Significance Index: -0.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0270
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0284
    Cell Significance Index: -0.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0287
    Cell Significance Index: -0.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0295
    Cell Significance Index: -0.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0307
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0315
    Cell Significance Index: -0.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0315
    Cell Significance Index: -0.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0316
    Cell Significance Index: -0.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0317
    Cell Significance Index: -1.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0333
    Cell Significance Index: -0.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0334
    Cell Significance Index: -0.8500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0338
    Cell Significance Index: -0.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0365
    Cell Significance Index: -0.9100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0366
    Cell Significance Index: -0.4800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0372
    Cell Significance Index: -0.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0379
    Cell Significance Index: -0.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0411
    Cell Significance Index: -0.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0411
    Cell Significance Index: -0.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0412
    Cell Significance Index: -0.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0424
    Cell Significance Index: -0.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0435
    Cell Significance Index: -0.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRISP1 is a secreted protein that belongs to the cysteine-rich secretory protein family. It is characterized by its unique structure, consisting of a secretory signal peptide, a cysteine-rich domain, and a C-terminal tail. This protein is highly expressed in various cell types, including erythrocytes, megakaryocytes, and hematopoietic stem cells. Its expression is also observed in endothelial cells and precursor B cells, suggesting a broad range of cellular functions. **Pathways and Functions:** CRISP1 is involved in multiple cellular pathways, including: 1. **Fertilization:** CRISP1 plays a crucial role in the fusion of sperm to the egg plasma membrane, a process essential for single fertilization. This protein is also involved in the regulation of the acrosome reaction, a critical step in fertilization. 2. **Cell Signaling:** CRISP1 acts as a calcium channel regulator, modulating calcium influx into cells. This function is essential for various cellular processes, including cell proliferation, differentiation, and survival. 3. **Immune Regulation:** CRISP1 is expressed in immune cells, such as plasma cells and precursor B cells, suggesting its involvement in immune responses. Its expression in erythrocytes and endothelial cells further supports its role in immune regulation and vascular health. 4. **Extracellular Space:** CRISP1 is secreted into the extracellular space, where it can interact with other proteins and modulate cellular signaling pathways. **Clinical Significance:** The dysregulation of CRISP1 has been implicated in various diseases, including: 1. **Reproductive Disorders:** Abnormalities in CRISP1 expression have been linked to infertility and miscarriage. 2. **Immune Diseases:** Alterations in CRISP1 expression have been observed in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** CRISP1 has been implicated in cancer progression, particularly in hematological malignancies. 4. **Vascular Diseases:** Dysregulation of CRISP1 has been linked to vascular dysfunction and atherosclerosis. In conclusion, CRISP1 is a multifunctional protein that plays a critical role in immune regulation, cell signaling, and fertilization. Its dysregulation has been implicated in various diseases, highlighting the importance of CRISP1 in maintaining cellular homeostasis and overall health. Further research is necessary to fully understand the mechanisms by which CRISP1 regulates cellular processes and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 2059426742

Symbol: CRIS1_HUMAN

Name: Cysteine-rich secretory protein 1

UniProtKB Accession Codes:

P54107 B5BU98 O00698 Q13248 Q14082 Q96SF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8665901

Title: The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.

PubMed ID: 8665901

DOI: 10.1111/j.1432-1033.1996.t01-1-00827.x

PubMed ID: 8543280

Title: Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization.

PubMed ID: 8543280

PubMed ID: 8838800

Title: Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1).

PubMed ID: 8838800

DOI: 10.1006/geno.1996.0131

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 249
  • Mass: 28481
  • Checksum: 85BED3DDEAD62A9C
  • Sequence:
    • MEIKHLLFLV AAACLLPMLS MKKKSARDQF NKLVTDLPNV QEEIVNIHNA LRRRVVPPAS 
NMLKMSWSEE AAQNARIFSK YCDMTESNPL ERRLPNTFCG ENMHMTSYPV SWSSVIGVWY 
SESTSFKHGE WTTTDDDITT DHYTQIVWAT SYLIGCAIAS CRQQGSPRYL YVCHYCHEGN 
DPETKNEPYK TGVPCEACPS NCEDKLCTNP CIYYDEYFDC DIQVHYLGCN HSTTILFCKA 
TCLCDTEIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.