Genular: Defining Cellular Identity and Function

Details for: Lag3

Gene ID: 16768

Symbol: Lag3

Ensembl ID: ENSMUSG00000030124

Description: lymphocyte-activation gene 3

Associated with

Adaptive immune system
(R-MMU-1280218)
Immune system
(R-MMU-168256)
Mhc class ii antigen presentation
(R-MMU-2132295)
Adaptive immune response
(GO:0002250)
Cell surface receptor signaling pathway
(GO:0007166)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Immune system process
(GO:0002376)
Interleukin-2 production
(GO:0032623)
Membrane
(GO:0016020)
Mhc class ii protein binding
(GO:0042289)
Natural killer cell mediated cytotoxicity
(GO:0042267)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of regulatory t cell differentiation
(GO:0045590)
Negative regulation of t cell activation
(GO:0050868)
Plasmacytoid dendritic cell activation
(GO:0002270)
Plasma membrane
(GO:0005886)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Protein binding
(GO:0005515)
Regulation of immune response
(GO:0050776)
T cell activation
(GO:0042110)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

LAG3_MOUSE

Genular Protein ID: 4195979777

Symbol: LAG3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q61790 Q0VBL2

Database IDs:

Citations:

PubMed ID: 8921170

Title: Cloning of murine LAG-3 by magnetic bead bound homologous probes and PCR (gene-capture PCR).

PubMed ID: 8921170

DOI: 10.1006/abio.1996.0382

PubMed ID: 8602528

Title: Independent modes of natural killing distinguished in mice lacking Lag3.

PubMed ID: 8602528

DOI: 10.1126/science.272.5260.405

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12209638

Title: Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).

PubMed ID: 12209638

DOI: 10.1002/1521-4141(200208)32:8<2255::aid-immu2255>3.0.co;2-a

PubMed ID: 11937541

Title: Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223).

PubMed ID: 11937541

DOI: 10.4049/jimmunol.168.8.3874

PubMed ID: 12421911

Title: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3.

PubMed ID: 12421911

DOI: 10.4049/jimmunol.169.10.5392

PubMed ID: 12672063

Title: The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells.

PubMed ID: 12672063

DOI: 10.1002/eji.200323382

PubMed ID: 15485628

Title: Role of LAG-3 in regulatory T cells.

PubMed ID: 15485628

DOI: 10.1016/j.immuni.2004.08.010

PubMed ID: 15100286

Title: Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.

PubMed ID: 15100286

DOI: 10.4049/jimmunol.172.9.5450

PubMed ID: 15557174

Title: Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223).

PubMed ID: 15557174

DOI: 10.4049/jimmunol.173.11.6806

PubMed ID: 15634887

Title: Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).

PubMed ID: 15634887

DOI: 10.4049/jimmunol.174.2.688

PubMed ID: 17245433

Title: Metalloproteases regulate T-cell proliferation and effector function via LAG-3.

PubMed ID: 17245433

DOI: 10.1038/sj.emboj.7601520

PubMed ID: 19201841

Title: LAG-3 regulates plasmacytoid dendritic cell homeostasis.

PubMed ID: 19201841

DOI: 10.4049/jimmunol.0800185

PubMed ID: 21300912

Title: PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

PubMed ID: 21300912

DOI: 10.1084/jem.20100466

PubMed ID: 21873518

Title: Accelerated autoimmune diabetes in the absence of LAG-3.

PubMed ID: 21873518

DOI: 10.4049/jimmunol.1100714

PubMed ID: 30580966

Title: Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3.

PubMed ID: 30580966

DOI: 10.1016/j.cell.2018.11.010

PubMed ID: 30349037

Title: LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.

PubMed ID: 30349037

DOI: 10.1038/s41590-018-0217-9

Sequence Information:

Length: 521
Mass: 56978
Checksum: 64C29C40EB780E48
Sequence:

MREDLLLGFL LLGLLWEAPV VSSGPGKELP VVWAQEGAPV HLPCSLKSPN LDPNFLRRGG 
VIWQHQPDSG QPTPIPALDL HQGMPSPRQP APGRYTVLSV APGGLRSGRQ PLHPHVQLEE 
RGLQRGDFSL WLRPALRTDA GEYHATVRLP NRALSCSLRL RVGQASMIAS PSGVLKLSDW 
VLLNCSFSRP DRPVSVHWFQ GQNRVPVYNS PRHFLAETFL LLPQVSPLDS GTWGCVLTYR 
DGFNVSITYN LKVLGLEPVA PLTVYAAEGS RVELPCHLPP GVGTPSLLIA KWTPPGGGPE 
LPVAGKSGNF TLHLEAVGLA QAGTYTCSIH LQGQQLNATV TLAVITVTPK SFGLPGSRGK 
LLCEVTPASG KERFVWRPLN NLSRSCPGPV LEIQEARLLA ERWQCQLYEG QRLLGATVYA 
AESSSGAHSA RRISGDLKGG HLVLVLILGA LSLFLLVAGA FGFHWWRKQL LLRRFSALEH 
GIQPFPAQRK IEELERELET EMGQEPEPEP EPQLEPEPRQ L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lag3

Associated with

Other Information

Cloning of murine LAG-3 by magnetic bead bound homologous probes and PCR (gene-capture PCR). PubMed ID: 8921170

Independent modes of natural killing distinguished in mice lacking Lag3. PubMed ID: 8602528

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). PubMed ID: 12209638

Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). PubMed ID: 11937541

Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. PubMed ID: 12421911

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. PubMed ID: 12672063

Role of LAG-3 in regulatory T cells. PubMed ID: 15485628

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. PubMed ID: 15100286

Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223). PubMed ID: 15557174

Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). PubMed ID: 15634887

Metalloproteases regulate T-cell proliferation and effector function via LAG-3. PubMed ID: 17245433

LAG-3 regulates plasmacytoid dendritic cell homeostasis. PubMed ID: 19201841

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. PubMed ID: 21300912

Accelerated autoimmune diabetes in the absence of LAG-3. PubMed ID: 21873518

Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. PubMed ID: 30580966

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII. PubMed ID: 30349037