Genular: Defining Cellular Identity and Function

Details for: Lamp2

Gene ID: 16784

Symbol: Lamp2

Ensembl ID: ENSMUSG00000016534

Description: lysosomal-associated membrane protein 2

Associated with

Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Autolysosome
(GO:0044754)
Autophagosome maturation
(GO:0097352)
Autophagosome membrane
(GO:0000421)
Autophagy
(GO:0006914)
Cellular response to starvation
(GO:0009267)
Chaperone-mediated autophagy
(GO:0061684)
Chaperone-mediated autophagy translocation complex
(GO:0061742)
Cytoplasmic vesicle
(GO:0031410)
Endosome
(GO:0005768)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Intracellular membrane-bounded organelle
(GO:0043231)
Ion channel inhibitor activity
(GO:0008200)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lysosomal lumen acidification
(GO:0007042)
Lysosomal matrix
(GO:1990836)
Lysosomal membrane
(GO:0005765)
Lysosomal protein catabolic process
(GO:1905146)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Muscle cell cellular homeostasis
(GO:0046716)
Negative regulation of nlrp3 inflammasome complex assembly
(GO:1900226)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytic vesicle membrane
(GO:0030670)
Plasma membrane
(GO:0005886)
Platelet dense granule membrane
(GO:0031088)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein domain specific binding
(GO:0019904)
Protein stabilization
(GO:0050821)
Protein targeting
(GO:0006605)
Protein targeting to lysosome involved in chaperone-mediated autophagy
(GO:0061740)
Regulation of protein stability
(GO:0031647)
Signaling adaptor activity
(GO:0035591)
Trans-golgi network
(GO:0005802)

Other Information

Proteins

Lysosome-associated membrane glycoprotein 2
Q8C5K0_MOUSE

Genular Protein ID: 4095169826

Symbol: LAMP2_MOUSE

Name: Lysosome-associated membrane glycoprotein 2

UniProtKB Accession Codes:

P17047 A2A430 Q3TXG5 Q8BSG8

Database IDs:

Citations:

PubMed ID: 2318880

Title: The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins.

PubMed ID: 2318880

DOI: 10.1016/s0021-9258(19)34076-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2142158

Title: Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.

PubMed ID: 2142158

DOI: 10.1016/s0021-9258(19)38504-7

PubMed ID: 7546292

Title: The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c.

PubMed ID: 7546292

DOI: 10.1089/dna.1995.14.863

PubMed ID: 11082038

Title: Unique properties of lamp2a compared to other lamp2 isoforms.

PubMed ID: 11082038

DOI: 10.1242/jcs.113.24.4441

PubMed ID: 10972293

Title: Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.

PubMed ID: 10972293

DOI: 10.1038/35022595

PubMed ID: 12221139

Title: Role of LAMP-2 in lysosome biogenesis and autophagy.

PubMed ID: 12221139

DOI: 10.1091/mbc.e02-02-0114

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22641697

Title: The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.

PubMed ID: 22641697

DOI: 10.1242/jcs.087346

PubMed ID: 27628032

Title: LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

PubMed ID: 27628032

DOI: 10.1242/bio.018648

PubMed ID: 27663661

Title: Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes.

PubMed ID: 27663661

DOI: 10.1016/j.bbrc.2016.09.093

Sequence Information:

Length: 415
Mass: 45681
Checksum: 053A874B4DF67C88
Sequence:

MCLSPVKGAK LILIFLFLGA VQSNALIVNL TDSKGTCLYA EWEMNFTITY ETTNQTNKTI 
TIAVPDKATH DGSSCGDDRN SAKIMIQFGF AVSWAVNFTK EASHYSIHDI VLSYNTSDST 
VFPGAVAKGV HTVKNPENFK VPLDVIFKCN SVLTYNLTPV VQKYWGIHLQ AFVQNGTVSK 
NEQVCEEDQT PTTVAPIIHT TAPSTTTTLT PTSTPTPTPT PTPTVGNYSI RNGNTTCLLA 
TMGLQLNITE EKVPFIFNIN PATTNFTGSC QPQSAQLRLN NSQIKYLDFI FAVKNEKRFY 
LKEVNVYMYL ANGSAFNISN KNLSFWDAPL GSSYMCNKEQ VLSVSRAFQI NTFNLKVQPF 
NVTKGQYSTA QDCSADEDNF LVPIAVGAAL GGVLILVLLA YFIGLKRHHT GYEQF

Genular Protein ID: 3961753792

Symbol: Q8C5K0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C5K0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 416
Mass: 45797
Checksum: F6FE0E2F2B5689E2
Sequence:

MCLSPVKGAK LILIFLFLGA VQSNALIVNL TDSKGTCLYA EWEMNFTITY ETTNQTNKTI 
TIAVPDKATH DGSSCGDDRN SAKIMIQFGF AVSWAVNFTK EASHYSIHDI VLSYNTSDST 
VFPGAVAKGV HTVKNPENFK VPLDVIFKCN SVLTYNLTPV VQKYWGIHLQ AFVQNGTVSK 
NEQVCEEDQT PTTVAPIIHT TAPSTTTTLT PTSTPTPTPT PTPTVGNYSI RNGNTTCLLA 
TMGLQLNITE EKVPFIFNIN PATTNFTGSC QPQSAQLRLN NSQIKYLDFI FAVKNEKRFY 
LKEVNVYMYL ANGSAFNISN KNLSFWDAPL GSSYMCNKEQ VLSVSRAFQI NTFNLKVQPF 
NVTKGQYSTA EECAADSDLN FLIPVAVGVA LGFLIIAVFI SYMIGRRKSR TGYQSV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lamp2

Associated with

Other Information

The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. PubMed ID: 2318880

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells. PubMed ID: 2142158

The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c. PubMed ID: 7546292

Unique properties of lamp2a compared to other lamp2 isoforms. PubMed ID: 11082038

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. PubMed ID: 10972293

Role of LAMP-2 in lysosome biogenesis and autophagy. PubMed ID: 12221139

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. PubMed ID: 22641697

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes. PubMed ID: 27628032

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. PubMed ID: 27663661

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073