Details for: Laptm5

Gene ID: 16792

Symbol: Laptm5

Ensembl ID: ENSMUSG00000028581

Description: lysosomal-associated protein transmembrane 5

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Cytoplasmic vesicle
    (GO:0031410)
  • Defense response to tumor cell
    (GO:0002357)
  • Enzyme binding
    (GO:0019899)
  • Golgi to lysosome transport
    (GO:0090160)
  • Induction of programmed cell death
    (GO:0012502)
  • Intracellular protein transport
    (GO:0006886)
  • Lysosomal membrane
    (GO:0005765)
  • Lysosome
    (GO:0005764)
  • Membrane
    (GO:0016020)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of autophagic cell death
    (GO:1904093)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of pre-b cell receptor expression
    (GO:0140646)
  • Negative regulation of t cell activation
    (GO:0050868)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of lysosomal membrane permeability
    (GO:0097214)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of proteolysis involved in protein catabolic process
    (GO:1903052)
  • Positive regulation of receptor catabolic process
    (GO:2000646)
  • Positive regulation of tumor necrosis factor-mediated signaling pathway
    (GO:1903265)
  • Positive regulation of ubiquitin-dependent protein catabolic process
    (GO:2000060)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein localization to lysosome
    (GO:0061462)
  • Protein sequestering activity
    (GO:0140311)
  • Protein targeting to lysosome
    (GO:0006622)
  • Transport vesicle
    (GO:0030133)
  • Ubiquitin-dependent protein binding
    (GO:0140036)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 4021919316

Symbol: LAPM5_MOUSE

Name: Lysosomal-associated transmembrane protein 5

UniProtKB Accession Codes:

Q61168 Q60923

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 39 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 STRING 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8661146

Title: LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.

PubMed ID: 8661146

DOI: 10.1006/geno.1996.0364

PubMed ID: 8839844

Title: E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.

PubMed ID: 8839844

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

Sequence Information:

  • Length: 261
  • Mass: 29602
  • Checksum: 70B3FA0AFE6743D1
  • Sequence:
    • MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC RFFKMPYLRM 
ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI MDFLLCLLTL LGSYIELPAY 
LKLARPRPGP SKVPLMTLQL LDFCLSILTL CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH 
SQFINMMLIF SVAFITVLIL KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE 
ALSLPPKTPE GDPAPPPYSE V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.