Genular: Defining Cellular Identity and Function

Details for: Large1

Gene ID: 16795

Symbol: Large1

Ensembl ID: ENSMUSG00000004383

Description: LARGE xylosyl- and glucuronyltransferase 1

Associated with

Metabolism of proteins
(R-MMU-392499)
O-linked glycosylation
(R-MMU-5173105)
Astrocyte differentiation
(GO:0048708)
Behavioral fear response
(GO:0001662)
Blood vessel development
(GO:0001568)
Bone development
(GO:0060348)
Brain development
(GO:0007420)
Cardiac muscle cell development
(GO:0055013)
Cardiac muscle tissue development
(GO:0048738)
Catalytic activity
(GO:0003824)
Cellular component organization
(GO:0016043)
Chemical synaptic transmission
(GO:0007268)
Cytoskeleton organization
(GO:0007010)
Dentate gyrus development
(GO:0021542)
Determination of adult lifespan
(GO:0008340)
Gene expression
(GO:0010467)
Glucuronosyltransferase activity
(GO:0015020)
Glycoprotein biosynthetic process
(GO:0009101)
Glycoprotein metabolic process
(GO:0009100)
Glycosyltransferase activity
(GO:0016757)
Heart development
(GO:0007507)
Hexosyltransferase activity
(GO:0016758)
Intracellular protein transport
(GO:0006886)
Limb development
(GO:0060173)
Localization of cell
(GO:0051674)
Long-term synaptic potentiation
(GO:0060291)
Macrophage differentiation
(GO:0030225)
Manganese ion binding
(GO:0030145)
Memory
(GO:0007613)
Metabolic process
(GO:0008152)
Metal ion binding
(GO:0046872)
Multicellular organism growth
(GO:0035264)
Multicellular organism reproduction
(GO:0032504)
Muscle cell cellular homeostasis
(GO:0046716)
Muscle organ development
(GO:0007517)
Myelination
(GO:0042552)
Myotube differentiation
(GO:0014902)
Nerve development
(GO:0021675)
Neuromuscular junction development
(GO:0007528)
Neuromuscular process
(GO:0050905)
Neuromuscular process controlling posture
(GO:0050884)
Neuromuscular synaptic transmission
(GO:0007274)
Neuron migration
(GO:0001764)
Plasma membrane organization
(GO:0007009)
Post-embryonic hindlimb morphogenesis
(GO:0035129)
Post-translational protein modification
(GO:0043687)
Principal sensory nucleus of trigeminal nerve development
(GO:0021740)
Protein binding
(GO:0005515)
Protein deglycosylation
(GO:0006517)
Protein glycosylation
(GO:0006486)
Protein localization
(GO:0008104)
Protein modification process
(GO:0036211)
Protein o-linked glycosylation
(GO:0006493)
Protein o-linked mannosylation
(GO:0035269)
Protein phosphorylation
(GO:0006468)
Protein targeting to membrane
(GO:0006612)
Regulation of kinase activity
(GO:0043549)
Regulation of protein binding
(GO:0043393)
Regulation of synaptic plasticity
(GO:0048167)
Response to light stimulus
(GO:0009416)
Response to mechanical stimulus
(GO:0009612)
Retina development in camera-type eye
(GO:0060041)
Retina layer formation
(GO:0010842)
Sensory perception of sound
(GO:0007605)
Skeletal muscle fiber development
(GO:0048741)
Skeletal muscle organ development
(GO:0060538)
Skeletal muscle tissue regeneration
(GO:0043403)
Striated muscle cell development
(GO:0055002)
Striated muscle contraction
(GO:0006941)
Synapse organization
(GO:0050808)
Synaptic assembly at neuromuscular junction
(GO:0051124)
Transferase activity
(GO:0016740)
Transmembrane transport
(GO:0055085)
Water transport
(GO:0006833)
Xylosyltransferase activity
(GO:0042285)

Other Information

Proteins

Acetylglucosaminyltransferase-like 1A

Genular Protein ID: 384402354

Symbol: LARG1_MOUSE

Name: Acetylglucosaminyltransferase-like 1A

UniProtKB Accession Codes:

Q9Z1M7 Q497S9 Q6P7U2 Q80TW0

Database IDs:

Citations:

PubMed ID: 9892679

Title: The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family.

PubMed ID: 9892679

DOI: 10.1073/pnas.96.2.598

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12693553

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 12693553

DOI: 10.1093/dnares/10.1.35

PubMed ID: 11381262

Title: Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse.

PubMed ID: 11381262

DOI: 10.1038/88865

PubMed ID: 15210115

Title: Molecular recognition by LARGE is essential for expression of functional dystroglycan.

PubMed ID: 15210115

DOI: 10.1016/j.cell.2004.06.003

PubMed ID: 15958417

Title: Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.

PubMed ID: 15958417

DOI: 10.1093/glycob/cwi094

PubMed ID: 15184894

Title:

PubMed ID: 15184894

DOI: 10.1038/nm1059

PubMed ID: 23125099

Title: Xylosyl- and glucuronyltransferase functions of LARGE in alpha-dystroglycan modification are conserved in LARGE2.

PubMed ID: 23125099

DOI: 10.1093/glycob/cws152

PubMed ID: 23135544

Title: LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.

PubMed ID: 23135544

DOI: 10.1093/glycob/cws153

PubMed ID: 24132234

Title: LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy.

PubMed ID: 24132234

DOI: 10.1038/nature12605

PubMed ID: 25138275

Title: Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of alpha-dystroglycan in cells and tissues.

PubMed ID: 25138275

DOI: 10.1074/jbc.m114.597831

PubMed ID: 32975514

Title: POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan.

PubMed ID: 32975514

DOI: 10.7554/elife.61388

Sequence Information:

Length: 756
Mass: 87964
Checksum: 37B32E039AB8895F
Sequence:

MLGICRGRRK FLAASLTLLC IPAITWIYLF AGSFEDGKPV SLSPLESQAH SPRYTASSQR 
ERESLEVRVR EVEEENRALR RQLSLAQGQS PAHHRGNHSK TYSMEEGTGD SENLRAGIVA 
GNSSECGQQP AVEKCETIHV AIVCAGYNAS RDVVTLVKSV LFHRRNPLHF HLIADSIAEQ 
ILATLFQTWM VPAVRVDFYN ADELKSEVSW IPNKHYSGIY GLMKLVLTKT LPANLERVIV 
LDTDITFATD IAELWAVFHK FKGQQVLGLV ENQSDWYLGN LWKNHRPWPA LGRGYNTGVI 
LLLLDKLRKM KWEQMWRLTA ERELMGMLST SLADQDIFNA VIKQNPFLVY QLPCFWNVQL 
SDHTRSEQCY RDVSDLKVIH WNSPKKLRVK NKHVEFFRNL YLTFLEYDGN LLRRELFGCP 
SETDVNNENL QKQLSELDED DLCYEFRRER FTVHRTHLYF LHYEFEPSAD NTDVTLVAQL 
SMDRLQMLEA ICKHWEGPIS LALYLSDAEA QQFLRYAQGS EVLMSRQNVG YHIVYKEGQF 
YPVNLLRNVA MKHISTPYMF LSDIDFLPMY GLYEYLRKSV IQLDLANTKK AMIVPAFETL 
RYRLSFPKSK AELLSMLDMG TLFTFRYHVW TKGHAPTNFA KWRTATTPYQ VEWEADFEPY 
VVVRRDCPEY DRRFVGFGWN KVAHIMELDA QEYEFTVLPN AYMIHMPHAP SFDITKFRSN 
KQYRICLKTL KEEFQQDMSR RYGFAALKYL TAENNS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Large1

Associated with

Other Information

The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family. PubMed ID: 9892679

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 12693553

Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. PubMed ID: 11381262

Molecular recognition by LARGE is essential for expression of functional dystroglycan. PubMed ID: 15210115

Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. PubMed ID: 15958417