Genular: Defining Cellular Identity and Function

Details for: Lats1

Gene ID: 16798

Symbol: Lats1

Ensembl ID: ENSMUSG00000040021

Description: large tumor suppressor

Associated with

Signaling by hippo
(R-MMU-2028269)
Signal transduction
(R-MMU-162582)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Cytoplasm
(GO:0005737)
Cytoplasmic sequestering of protein
(GO:0051220)
Cytoskeleton
(GO:0005856)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Hippo signaling
(GO:0035329)
Hormone-mediated signaling pathway
(GO:0009755)
Inner cell mass cell fate commitment
(GO:0001827)
Inner cell mass cellular morphogenesis
(GO:0001828)
Keratinocyte differentiation
(GO:0030216)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Mammary gland epithelial cell differentiation
(GO:0060644)
Metal ion binding
(GO:0046872)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of protein localization to nucleus
(GO:1900181)
Nuclear estrogen receptor binding
(GO:0030331)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of actin filament polymerization
(GO:0030833)
Regulation of intracellular estrogen receptor signaling pathway
(GO:0033146)
Regulation of organ growth
(GO:0046620)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Regulation of ubiquitin-dependent protein catabolic process
(GO:2000058)
Sister chromatid segregation
(GO:0000819)
Spindle pole
(GO:0000922)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase LATS1

Genular Protein ID: 2001622349

Symbol: LATS1_MOUSE

Name: Serine/threonine-protein kinase LATS1

UniProtKB Accession Codes:

Q8BYR2 B2RY46 Q9Z0W4

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9988268

Title: Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.

PubMed ID: 9988268

DOI: 10.1038/5960

PubMed ID: 9988269

Title: Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.

PubMed ID: 9988269

DOI: 10.1038/5965

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

Sequence Information:

Length: 1129
Mass: 126258
Checksum: FCDC2EC8BC2FF2DE
Sequence:

MKRGEKPEGY RQMRPKTFPA SNYPGSSRQM LQEIRESLRN LSKPSDASKA EHNLNKMSTE 
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETSSSRSPSE VNPQMFQDLQ AAGFDEDMVI 
QALQKTNNRS IEAAVEFISK MSYQDPRREQ MSAAAARPIN ATMKPGNVQH SINRKQSWKG 
SKESLVPQRH GPSLGENVVY RSESPNSQAD VGRPLSGSGI AAFAQAHPSN GQRVNPPPPP 
QVRSVTPPPP PRGQTPPPRG TTPPPPSWEP SSQTKRYSGN MEYVISRISP VPPGAWQEGY 
PPPPLTTSPM NPPSQAQRAI SSVPVGRQPI IMQSTSKFNF TPGRPGVQNG GGQSDFIVHQ 
NVPTGSVTRQ PPPPYPLTPA NGQSPSALQT GASAAPPSFA NGNVPQSMMV PNRNSHNMEL 
YNINVPGLQT AWPQSSSAPA QSSPSGGHEI PTWQPNIPVR SNSFNNPLGS RASHSANSQP 
SATTVTAITP APIQQPVKSM RVLKPELQTA LAPTHPSWMP QPVQTVQPTP FSEGTASSVP 
VIPPVAEAPS YQGPPPPYPK HLLHQNPSVP PYESVSKPCK DEQPSLPKED DSEKSADSGD 
SGDKEKKQIT TSPITVRKNK KDEERRESRI QSYSPQAFKF FMEQHVENVL KSHQQRLHRK 
KQLENEMMRV GLSQDAQDQM RKMLCQKESN YIRLKRAKMD KSMFVKIKTL GIGAFGEVCL 
ARKVDTKALY ATKTLRKKDV LLRNQVAHVK AERDILAEAD NEWVVRLYYS FQDKDNLYFV 
MDYIPGGDMM SLLIRMGIFP ENLARFYIAE LTCAVESVHK MGFIHRDIKP DNILIDRDGH 
IKLTDFGLCT GFRWTHDSKY YQSGDHPRQD SMDFSNEWGD PSNCRCGDRL KPLERRAARQ 
HQRCLAHSLV GTPNYIAPEV LLRTGYTQLC DWWSVGVILF EMLVGQPPFL AQTPLETQMK 
VINWQTSLHI PPQAKLSPEA SDLIIKLCRG PEDRLGKNGA DEIKAHPFFK TIDFSSDLRQ 
QSASYIPKIT HPTDTSNFDP VDPDKLWSDG SEEENISDTL NGWYKNGKHP EHAFYEFTFR 
RFFDDNGYPY NYPKPIEYEY IHSQGSEQQS DEDDQHTSSD GNNRDLVYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lats1

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. PubMed ID: 9988268

Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. PubMed ID: 9988269

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499