Genular: Defining Cellular Identity and Function

Details for: Lbp

Gene ID: 16803

Symbol: Lbp

Ensembl ID: ENSMUSG00000016024

Description: lipopolysaccharide binding protein

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Transfer of lps from lbp carrier to cd14
(R-MMU-166020)
Acute-phase response
(GO:0006953)
Cell surface
(GO:0009986)
Cell surface pattern recognition receptor signaling pathway
(GO:0002752)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to lipoteichoic acid
(GO:0071223)
Coreceptor activity
(GO:0015026)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Detection of molecule of bacterial origin
(GO:0032490)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Leukocyte chemotaxis involved in inflammatory response
(GO:0002232)
Lipid binding
(GO:0008289)
Lipid transport
(GO:0006869)
Lipopeptide binding
(GO:0071723)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide transport
(GO:0015920)
Lipoteichoic acid binding
(GO:0070891)
Macrophage activation involved in immune response
(GO:0002281)
Membrane
(GO:0016020)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Positive regulation of respiratory burst involved in inflammatory response
(GO:0060265)
Positive regulation of toll-like receptor 4 signaling pathway
(GO:0034145)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Regulation of membrane permeability
(GO:0090559)
Response to lipopolysaccharide
(GO:0032496)
Signaling receptor binding
(GO:0005102)
Tumor necrosis factor production
(GO:0032640)

Other Information

Proteins

Lipopolysaccharide-binding protein

Genular Protein ID: 3134390237

Symbol: LBP_MOUSE

Name: Lipopolysaccharide-binding protein

UniProtKB Accession Codes:

Q61805 A2AC66 Q99KA0

Database IDs:

Citations:

PubMed ID: 9144073

Title: Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and Gram-negative bacteria.

PubMed ID: 9144073

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24380872

Title: The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

PubMed ID: 24380872

DOI: 10.1093/intimm/dxt071

PubMed ID: 24120359

Title: The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.

PubMed ID: 24120359

DOI: 10.1016/j.immuni.2013.09.005

Sequence Information:

Length: 481
Mass: 53055
Checksum: AC1D3FC2DA87FE9A
Sequence:

MKAGTGPLLS TLLGLLFLSI QGTGGVNPGV VARITDKGLA YAAKEGLVAL QRELYKITLP 
DFSGDFKIKA VGRGQYEFHS LEIQNCELRG SSLKLLPGQG LSLAISDSSI GVRGKWKVRK 
SFLKLHGSFD LDVKGVTISV DLLLGMDPSG RPTVSASGCS SRICDLDVHI SGNVGWLLNL 
FHNQIESKLQ KVLENKVCEM IQKSVTSDLQ PYLQTLPVTA EIDNVLGIDY SLVAAPQAKA 
QVLDVMFKGE IFNRNHRSPV ATPTPTMSLP EDSKQMVYFA ISDYAFNIAS RVYHQAGYLN 
FSITDDMLPH DSGIRLNTKA FRPFTPQIYK KYPDMKLELL GTVVSAPILN VSPGNLSLAP 
QMEIEGFVIL PTSAREPVFR LGVVTNVFAS LTFNNSKVTG MLHPDKAQVR LIESKVGMFN 
VNLFQAFLNY YLLNSLYPDV NAELAQGFPL PLPRHIQLHD LDFQIRKDFL YLGANVQYMR 
V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lbp

Associated with

Other Information

Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and Gram-negative bacteria. PubMed ID: 9144073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334