Genular: Defining Cellular Identity and Function

Details for: Lcn2

Gene ID: 16819

Symbol: Lcn2

Ensembl ID: ENSMUSG00000026822

Description: lipocalin 2

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Iron uptake and transport
(R-MMU-917937)
Metal sequestration by antimicrobial proteins
(R-MMU-6799990)
Neutrophil degranulation
(R-MMU-6798695)
Transport of small molecules
(R-MMU-382551)
Apoptotic process
(GO:0006915)
Cellular response to hydrogen peroxide
(GO:0070301)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Enterobactin binding
(GO:1903981)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Iron ion binding
(GO:0005506)
Iron ion sequestering activity
(GO:0140315)
Iron ion transport
(GO:0006826)
Long-term memory
(GO:0007616)
Monoatomic ion transport
(GO:0006811)
Negative regulation of hippocampal neuron apoptotic process
(GO:0110091)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell projection organization
(GO:0031346)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial tube morphogenesis
(GO:1905956)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of hippocampal neuron apoptotic process
(GO:0110090)
Positive regulation of iron ion import across plasma membrane
(GO:1904440)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Response to bacterium
(GO:0009617)
Response to herbicide
(GO:0009635)
Response to virus
(GO:0009615)
Response to xenobiotic stimulus
(GO:0009410)
Short-term memory
(GO:0007614)
Siderophore transport
(GO:0015891)
Small molecule binding
(GO:0036094)

Other Information

Proteins

Neutrophil gelatinase-associated lipocalin

Genular Protein ID: 2932745896

Symbol: NGAL_MOUSE

Name: Neutrophil gelatinase-associated lipocalin

UniProtKB Accession Codes:

P11672 Q3UE34

Database IDs:

Citations:

PubMed ID: 2542864

Title: SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism.

PubMed ID: 2542864

PubMed ID: 8666241

Title: An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3.

PubMed ID: 8666241

DOI: 10.1016/0378-1119(95)00896-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8687399

Title: Demonstration of a glycoprotein derived from the 24p3 gene in mouse uterine luminal fluid.

PubMed ID: 8687399

DOI: 10.1042/bj3160545

PubMed ID: 1723819

Title: The first lipocalin with enzymatic activity.

PubMed ID: 1723819

DOI: 10.1016/0968-0004(91)90149-p

PubMed ID: 1834059

Title: Mouse oncogene protein 24p3 is a member of the lipocalin protein family.

PubMed ID: 1834059

DOI: 10.1016/s0006-291x(05)81256-2

PubMed ID: 12453413

Title: An iron delivery pathway mediated by a lipocalin.

PubMed ID: 12453413

DOI: 10.1016/s1097-2765(02)00710-4

PubMed ID: 15531878

Title: Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.

PubMed ID: 15531878

DOI: 10.1038/nature03104

PubMed ID: 16377569

Title: A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.

PubMed ID: 16377569

DOI: 10.1016/j.cell.2005.10.027

PubMed ID: 16446425

Title: Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

PubMed ID: 16446425

DOI: 10.1073/pnas.0510847103

PubMed ID: 20550936

Title: A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production.

PubMed ID: 20550936

DOI: 10.1016/j.cell.2010.04.040

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30418175

Title: Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.

PubMed ID: 30418175

DOI: 10.1172/jci98595

PubMed ID: 21911364

Title: Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.

PubMed ID: 21911364

DOI: 10.1093/nar/gkr706

Sequence Information:

Length: 200
Mass: 22875
Checksum: DD9A8D08750E6863
Sequence:

MALSVMCLGL ALLGVLQSQA QDSTQNLIPA PSLLTVPLQP DFRSDQFRGR WYVVGLAGNA 
VQKKTEGSFT MYSTIYELQE NNSYNVTSIL VRDQDQGCRY WIRTFVPSSR AGQFTLGNMH 
RYPQVQSYNV QVATTDYNQF AMVFFRKTSE NKQYFKITLY GRTKELSPEL KERFTRFAKS 
LGLKDDNIIF SVPTDQCIDN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lcn2

Associated with

Other Information

SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. PubMed ID: 2542864

An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3. PubMed ID: 8666241

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration of a glycoprotein derived from the 24p3 gene in mouse uterine luminal fluid. PubMed ID: 8687399

The first lipocalin with enzymatic activity. PubMed ID: 1723819

Mouse oncogene protein 24p3 is a member of the lipocalin protein family. PubMed ID: 1834059

An iron delivery pathway mediated by a lipocalin. PubMed ID: 12453413

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. PubMed ID: 15531878

A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. PubMed ID: 16377569

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. PubMed ID: 16446425

A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. PubMed ID: 20550936

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses. PubMed ID: 30418175

Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. PubMed ID: 21911364