Genular: Defining Cellular Identity and Function

Details for: Lcp2

Gene ID: 16822

Symbol: Lcp2

Ensembl ID: ENSMUSG00000002699

Description: lymphocyte cytosolic protein 2

Associated with

Adaptive immune system
(R-MMU-1280218)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Fceri mediated mapk activation
(R-MMU-2871796)
Generation of second messenger molecules
(R-MMU-202433)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Tcr signaling
(R-MMU-202403)
Cell-cell junction
(GO:0005911)
Cytokine production
(GO:0001816)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Mast cell activation
(GO:0045576)
Plasma membrane raft
(GO:0044853)
Protein binding
(GO:0005515)
T cell receptor signaling pathway
(GO:0050852)
Tcr signalosome
(GO:0036398)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Lymphocyte cytosolic protein 2

Genular Protein ID: 3090451307

Symbol: LCP2_MOUSE

Name: Lymphocyte cytosolic protein 2

UniProtKB Accession Codes:

Q60787 Q922M0

Database IDs:

Citations:

PubMed ID: 7706237

Title: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.

PubMed ID: 7706237

DOI: 10.1074/jbc.270.13.7029

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10660534

Title: Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.

PubMed ID: 10660534

DOI: 10.1074/jbc.275.6.3835

PubMed ID: 10662792

Title: Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling.

PubMed ID: 10662792

DOI: 10.1084/jem.191.3.463

PubMed ID: 10646608

Title: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.

PubMed ID: 10646608

DOI: 10.1038/35003228

PubMed ID: 16914752

Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.

PubMed ID: 16914752

DOI: 10.1128/mcb.00688-06

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24584089

Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

PubMed ID: 24584089

DOI: 10.1038/ni.2843

Sequence Information:

Length: 533
Mass: 60238
Checksum: 50AEA025EF0DAD01
Sequence:

MALKNVPFRS EVLAWNSDNL ADYFRKLNYR DCEKAVKKYH IDGARFLNLT ENDIQKFPKL 
RMPLLSKLSQ DINKNEERRS IFTRKPQIPR FLEETESHEE DDGGWSSFED DYESPNDDDP 
DGEDDGDYES PNEEEQALVD DAADYEPPPS NNEEALQSSI LPPNSFHNTN SMYIDRPPTG 
KVSQQPPVPP LRPKPALPPL PTGRNHSPLS PPHPNHEEPS RSGNNKTAKL PAPSIDRSTK 
PPLDRSLAPL DREPFILGKK PPFSDKPSAP LGREHLPKIQ KPPLPPAMDR HERNERLGPV 
TTRKPPVPRH GRGPDRREND EDDVHQRPLP QPSLPSMSSN TFPSRSVQPS SKNTFPLAHM 
PGAFSESNIG FQQSASLPPY FSQGPGNRPP LRSEGRNLPL PVPNRPQPPS PGEEETPLDE 
EWYVSYITRP EAEAALRKIN QDGTFLVRDS SKKTANNPYV LMVLYKDKVY NIQIRYQEES 
QVYLLGTGLR GKEDFLSVSD IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GCL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lcp2

Associated with

Other Information

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. PubMed ID: 7706237

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells. PubMed ID: 10660534

Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. PubMed ID: 10662792

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. PubMed ID: 10646608

CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. PubMed ID: 16914752

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. PubMed ID: 24584089