Genular: Defining Cellular Identity and Function

Details for: Ldb1

Gene ID: 16825

Symbol: Ldb1

Ensembl ID: ENSMUSG00000025223

Description: LIM domain binding 1

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-MMU-8939236)
Transcriptional regulation by runx1
(R-MMU-8878171)
Anterior/posterior axis specification
(GO:0009948)
Beta-catenin-tcf complex
(GO:1990907)
Cell adhesion
(GO:0007155)
Cell leading edge
(GO:0031252)
Cellular component assembly
(GO:0022607)
Cerebellar purkinje cell differentiation
(GO:0021702)
Cerebellum development
(GO:0021549)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Epithelial structure maintenance
(GO:0010669)
Gastrulation with mouth forming second
(GO:0001702)
Hair follicle development
(GO:0001942)
Head development
(GO:0060322)
Identical protein binding
(GO:0042802)
Lim domain binding
(GO:0030274)
Multicellular organism development
(GO:0007275)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of hemoglobin biosynthetic process
(GO:0046985)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Primitive erythrocyte differentiation
(GO:0060319)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein self-association
(GO:0043621)
Regulation of cell migration
(GO:0030334)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of kinase activity
(GO:0043549)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Somatic stem cell population maintenance
(GO:0035019)
Transcription-dependent tethering of rna polymerase ii gene dna at nuclear periphery
(GO:0000972)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Transcription regulator complex
(GO:0005667)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

LIM domain-binding protein 1

Genular Protein ID: 3133971314

Symbol: LDB1_MOUSE

Name: LIM domain-binding protein 1

UniProtKB Accession Codes:

P70662 O55204 Q1EQX2 Q71V68

Database IDs:

Citations:

PubMed ID: 8918878

Title: Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.

PubMed ID: 8918878

DOI: 10.1038/384270a0

PubMed ID: 8876198

Title: Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development.

PubMed ID: 8876198

DOI: 10.1073/pnas.93.21.11693

PubMed ID: 9192866

Title: A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.

PubMed ID: 9192866

DOI: 10.1101/gad.11.11.1370

PubMed ID: 9391090

Title: The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.

PubMed ID: 9391090

DOI: 10.1073/pnas.94.25.13707

PubMed ID: 9503020

Title: Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1.

PubMed ID: 9503020

DOI: 10.1006/geno.1997.5163

PubMed ID: 16815859

Title: Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.

PubMed ID: 16815859

DOI: 10.1093/jb/mvj134

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9315627

Title: Functional analysis of the nuclear LIM domain interactor NLI.

PubMed ID: 9315627

DOI: 10.1128/mcb.17.10.5688

PubMed ID: 9468533

Title: Interactions between LIM domains and the LIM domain-binding protein Ldb1.

PubMed ID: 9468533

DOI: 10.1074/jbc.273.8.4712

PubMed ID: 9860983

Title: Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators.

PubMed ID: 9860983

DOI: 10.1073/pnas.95.26.15418

PubMed ID: 10393337

Title: A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains.

PubMed ID: 10393337

DOI: 10.1093/oxfordjournals.jbchem.a022420

PubMed ID: 10330499

Title: Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex.

PubMed ID: 10330499

DOI: 10.1016/s0925-4773(98)00233-0

PubMed ID: 12150931

Title: LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

PubMed ID: 12150931

DOI: 10.1016/s0092-8674(02)00823-1

PubMed ID: 11882901

Title: Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.

PubMed ID: 11882901

DOI: 10.1038/416099a

PubMed ID: 16407974

Title: ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.

PubMed ID: 16407974

DOI: 10.1038/sj.emboj.7600934

PubMed ID: 18539116

Title: A regulatory network to segregate the identity of neuronal subtypes.

PubMed ID: 18539116

DOI: 10.1016/j.devcel.2008.03.021

PubMed ID: 19675209

Title: The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.

PubMed ID: 19675209

DOI: 10.1091/mbc.e08-07-0707

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 12727888

Title: Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.

PubMed ID: 12727888

DOI: 10.1093/emboj/cdg196

PubMed ID: 15343268

Title: Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex.

PubMed ID: 15343268

DOI: 10.1038/sj.emboj.7600376

PubMed ID: 23353824

Title: Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.

PubMed ID: 23353824

DOI: 10.1016/j.jmb.2013.01.017

Sequence Information:

Length: 411
Mass: 46503
Checksum: 47C53DFA23044580
Sequence:

MSVGCACPGC SSKSFKLYSP KEPPNGNAFP PFHPGTMLDR DVGPTPMYPP TYLEPGIGRH 
TPYGNQTDYR IFELNKRLQN WTEECDNLWW DAFTTEFFED DAMLTITFCL EDGPKRYTIG 
RTLIPRYFRS IFEGGATELY YVLKHPKEAF HSNFVSLDCD QGSMVTQHGK PMFTQVCVEG 
RLYLEFMFDD MMRIKTWHFS IRQHRELIPR SILAMHAQDP QMLDQLSKNI TRCGLSNSTL 
NYLRLCVILE PMQELMSRHK TYSLSPRDCL KTCLFQKWQR MVAPPAEPAR QQPSKRRKRK 
MSGGSTMSSG GGNTNNSNSK KKSPASTFAL SSQVPDVMVV GEPTLMGGEF GDEDERLITR 
LENTQFDAAN GIDDEDSFNN SPALGANSPW NSKPPSSQES KSENPTSQAS Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ldb1

Associated with

Other Information

Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. PubMed ID: 8918878

Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. PubMed ID: 8876198

A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. PubMed ID: 9192866

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. PubMed ID: 9391090

Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1. PubMed ID: 9503020

Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain. PubMed ID: 16815859

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional analysis of the nuclear LIM domain interactor NLI. PubMed ID: 9315627

Interactions between LIM domains and the LIM domain-binding protein Ldb1. PubMed ID: 9468533

Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. PubMed ID: 9860983

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. PubMed ID: 10393337

Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex. PubMed ID: 10330499

LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. PubMed ID: 12150931

Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. PubMed ID: 11882901

ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. PubMed ID: 16407974

A regulatory network to segregate the identity of neuronal subtypes. PubMed ID: 18539116

The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. PubMed ID: 19675209

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. PubMed ID: 12727888

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex. PubMed ID: 15343268

Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8. PubMed ID: 23353824