Genular: Defining Cellular Identity and Function

Details for: Lep

Gene ID: 16846

Symbol: Lep

Ensembl ID: ENSMUSG00000059201

Description: leptin

Associated with

Incretin synthesis, secretion, and inactivation
(R-MMU-400508)
Metabolism of proteins
(R-MMU-392499)
Peptide hormone metabolism
(R-MMU-2980736)
Synthesis, secretion, and deacylation of ghrelin
(R-MMU-422085)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-MMU-381771)
Adult feeding behavior
(GO:0008343)
Angiogenesis
(GO:0001525)
Aorta development
(GO:0035904)
Bile acid metabolic process
(GO:0008206)
Bone mineralization involved in bone maturation
(GO:0035630)
Cardiac muscle hypertrophy
(GO:0003300)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to leptin stimulus
(GO:0044320)
Central nervous system neuron development
(GO:0021954)
Cholesterol metabolic process
(GO:0008203)
Determination of adult lifespan
(GO:0008340)
Dna binding
(GO:0003677)
Eating behavior
(GO:0042755)
Energy reserve metabolic process
(GO:0006112)
Fatty acid beta-oxidation
(GO:0006635)
Fatty acid catabolic process
(GO:0009062)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Glycerol biosynthetic process
(GO:0006114)
Growth factor activity
(GO:0008083)
Hormone activity
(GO:0005179)
Hormone metabolic process
(GO:0042445)
Insulin secretion
(GO:0030073)
Intestinal absorption
(GO:0050892)
Intracellular signal transduction
(GO:0035556)
Leptin-mediated signaling pathway
(GO:0033210)
Leptin receptor binding
(GO:1990460)
Lipid metabolic process
(GO:0006629)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of appetite
(GO:0032099)
Negative regulation of appetite by leptin-mediated signaling pathway
(GO:0038108)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of metabolic process
(GO:0009892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vasoconstriction
(GO:0045906)
Ovulation from ovarian follicle
(GO:0001542)
Peptide hormone receptor binding
(GO:0051428)
Phagocytosis
(GO:0006909)
Placenta development
(GO:0001890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of monoatomic ion transport
(GO:0043270)
Positive regulation of myeloid cell differentiation
(GO:0045639)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Regulation of angiogenesis
(GO:0045765)
Regulation of blood pressure
(GO:0008217)
Regulation of bone remodeling
(GO:0046850)
Regulation of catalytic activity
(GO:0050790)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of gluconeogenesis
(GO:0006111)
Regulation of insulin secretion
(GO:0050796)
Regulation of intestinal cholesterol absorption
(GO:0030300)
Regulation of lipid biosynthetic process
(GO:0046890)
Regulation of metabolic process
(GO:0019222)
Regulation of natural killer cell activation
(GO:0032814)
Regulation of natural killer cell mediated cytotoxicity
(GO:0042269)
Regulation of natural killer cell proliferation
(GO:0032817)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of steroid biosynthetic process
(GO:0050810)
Response to dietary excess
(GO:0002021)
Response to insulin
(GO:0032868)
Sexual reproduction
(GO:0019953)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
T cell differentiation
(GO:0030217)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Leptin

Genular Protein ID: 1911746548

Symbol: LEP_MOUSE

Name: Leptin

UniProtKB Accession Codes:

P41160

Database IDs:

Citations:

PubMed ID: 7984236

Title: Positional cloning of the mouse obese gene and its human homologue.

PubMed ID: 7984236

DOI: 10.1038/372425a0

PubMed ID: 8589726

Title: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin.

PubMed ID: 8589726

DOI: 10.1038/ng0396-318

PubMed ID: 9732873

Title: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.

PubMed ID: 9732873

DOI: 10.1038/29795

PubMed ID: 10660043

Title: Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.

PubMed ID: 10660043

DOI: 10.1016/s0092-8674(00)81558-5

PubMed ID: 11373681

Title: Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus.

PubMed ID: 11373681

DOI: 10.1038/35078085

PubMed ID: 12594516

Title: STAT3 signalling is required for leptin regulation of energy balance but not reproduction.

PubMed ID: 12594516

DOI: 10.1038/nature01388

PubMed ID: 15122202

Title: The weight of leptin in immunity.

PubMed ID: 15122202

DOI: 10.1038/nri1350

PubMed ID: 15899045

Title: signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1.

PubMed ID: 15899045

DOI: 10.1186/ar1708

PubMed ID: 16825198

Title: Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2).

PubMed ID: 16825198

DOI: 10.1074/jbc.m601991200

PubMed ID: 20620997

Title: SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.

PubMed ID: 20620997

DOI: 10.1016/j.cmet.2010.05.010

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 25060689

Title: Leptin modulates autophagy in human CD4+CD25- conventional T cells.

PubMed ID: 25060689

DOI: 10.1016/j.metabol.2014.06.010

PubMed ID: 25383904

Title: Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.

PubMed ID: 25383904

DOI: 10.1038/nn.3861

Sequence Information:

Length: 167
Mass: 18709
Checksum: D6783E6C76FD7116
Sequence:

MCWRPLCRFL WLWSYLSYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL 
DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP 
QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lep

Associated with

Other Information

Positional cloning of the mouse obese gene and its human homologue. PubMed ID: 7984236

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. PubMed ID: 8589726

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. PubMed ID: 9732873

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. PubMed ID: 10660043

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. PubMed ID: 11373681

STAT3 signalling is required for leptin regulation of energy balance but not reproduction. PubMed ID: 12594516

The weight of leptin in immunity. PubMed ID: 15122202

signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. PubMed ID: 15899045

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). PubMed ID: 16825198

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. PubMed ID: 20620997

20 years of leptin: connecting leptin signaling to biological function. PubMed ID: 25232147

Leptin modulates autophagy in human CD4+CD25- conventional T cells. PubMed ID: 25060689

Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. PubMed ID: 25383904