Details for: Lepr

Gene ID: 16847

Symbol: Lepr

Ensembl ID: ENSMUSG00000057722

Description: leptin receptor

Associated with

Other Information

Genular Protein ID: 1173601801

Symbol: LEPR_MOUSE

Name: Leptin receptor

UniProtKB Accession Codes:

P48356 O35686 O54986 Q61215 Q64309 Q9QWG3 Q9QWV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 3 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 ELM 1 EMBL 81 EMDB 7 Ensembl 3 ExpressionAtlas 1 GO 40 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 10 PIR 5 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8548812

Title: Identification and expression cloning of a leptin receptor, OB-R.

PubMed ID: 8548812

DOI: 10.1016/0092-8674(95)90151-5

PubMed ID: 8608603

Title: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

PubMed ID: 8608603

DOI: 10.1016/s0092-8674(00)81294-5

PubMed ID: 8628397

Title: Abnormal splicing of the leptin receptor in diabetic mice.

PubMed ID: 8628397

DOI: 10.1038/379632a0

PubMed ID: 8616721

Title: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.

PubMed ID: 8616721

DOI: 10.1038/nm0596-585

PubMed ID: 8692797

Title: Defective STAT signaling by the leptin receptor in diabetic mice.

PubMed ID: 8692797

DOI: 10.1073/pnas.93.13.6231

PubMed ID: 9322935

Title: Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse.

PubMed ID: 9322935

DOI: 10.1210/endo.138.10.5428

PubMed ID: 9344648

Title: Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts.

PubMed ID: 9344648

DOI: 10.1006/geno.1997.4962

PubMed ID: 9845674

Title: Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain.

PubMed ID: 9845674

DOI: 10.1677/jme.0.0210337

PubMed ID: 9732873

Title: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.

PubMed ID: 9732873

DOI: 10.1038/29795

PubMed ID: 10660043

Title: Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.

PubMed ID: 10660043

DOI: 10.1016/s0092-8674(00)81558-5

PubMed ID: 11108838

Title: Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor.

PubMed ID: 11108838

DOI: 10.1016/s0014-5793(00)02205-5

PubMed ID: 10799542

Title: Activation of downstream signals by the long form of the leptin receptor.

PubMed ID: 10799542

DOI: 10.1074/jbc.275.19.14563

PubMed ID: 11018044

Title: SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.

PubMed ID: 11018044

DOI: 10.1074/jbc.m007577200

PubMed ID: 11861497

Title: Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.

PubMed ID: 11861497

DOI: 10.1210/endo.143.3.8669

PubMed ID: 12196522

Title: Regulation of Jak kinases by intracellular leptin receptor sequences.

PubMed ID: 12196522

DOI: 10.1074/jbc.m205148200

PubMed ID: 11923481

Title: Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers.

PubMed ID: 11923481

DOI: 10.1210/mend.16.4.0800

PubMed ID: 12594516

Title: STAT3 signalling is required for leptin regulation of energy balance but not reproduction.

PubMed ID: 12594516

DOI: 10.1038/nature01388

PubMed ID: 17620316

Title: Soluble receptor inhibits leptin transport.

PubMed ID: 17620316

DOI: 10.1002/jcp.21195

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20223942

Title: Unique leptin trafficking by a tailless receptor.

PubMed ID: 20223942

DOI: 10.1096/fj.09-143487

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 25383904

Title: Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.

PubMed ID: 25383904

DOI: 10.1038/nn.3861

Sequence Information:

  • Length: 1162
  • Mass: 130789
  • Checksum: 0E1E75B076BA60A2
  • Sequence:
    • MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 
KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 
RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 
FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 
GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 
SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 
AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 
SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 
VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 
LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 
SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 
MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 
YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH 
AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS SICISDQCNS 
ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE QGFIHSPVSN CISSNHSPLR 
QSFSSSSWET EAQTFFLLSD QQPTMISPQL SFSGLDELLE LEGSFPEENH REKSVCYLGV 
TSVNRRESGV LLTGEAGILC TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP 
QFQTCSTHSH KIMENKMCDL TV

Genular Protein ID: 235958134

Symbol: Q640Q2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q640Q2

Database IDs:

AGR 1 ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 InterPro 7 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 818
  • Mass: 92395
  • Checksum: BC4989D04B9ED8E1
  • Sequence:
    • MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 
KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 
RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 
FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 
GLHMEVTDDG NLKISWDSQT MAPSPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 
SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 
AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 
SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 
VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTFSWPMSKV 
SAVESLSAYP LSSSCVILSW TLSPDDYSLL YLVIEWKILN EDDGMKWLRI PSNVKKFYIH 
DNFIPIEKYQ FSLYPVFMEG VGKPKIINGF TKDAIDKQQN DAGLYVIVPI IISSCVLLLG 
TLLISHQRMK KLFWDDVPNP KNCSWAQGLN FQKRTDTL

Genular Protein ID: 2395467111

Symbol: Q3US58_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3US58

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 InterPro 8 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 Pfam 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 894
  • Mass: 101058
  • Checksum: DF9A7A0E5AC75A53
  • Sequence:
    • MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 
KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 
RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 
FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 
GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 
SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 
AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 
SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 
VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 
LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 
SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 
MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 
YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKR TDTL

Genular Protein ID: 1681758165

Symbol: Q3UNU8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UNU8

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 Genevisible 1 HOGENOM 1 InterPro 8 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 6 Pfam 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 892
  • Mass: 100771
  • Checksum: 726E5C075A53C9F3
  • Sequence:
    • MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 
KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 
RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 
FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 
GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 
SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 
AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 
SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 
VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 
LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 
SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 
MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 
YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKV TV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.