Details for: Lgals9

Gene ID: 16859

Symbol: Lgals9

Ensembl ID: ENSMUSG00000001123

Description: lectin, galactose binding, soluble 9

Associated with

  • Carbohydrate binding
    (GO:0030246)
  • Cellular response to virus
    (GO:0098586)
  • Chemotaxis
    (GO:0006935)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Disaccharide binding
    (GO:0048030)
  • Enzyme binding
    (GO:0019899)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Galactoside binding
    (GO:0016936)
  • Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
    (GO:0007157)
  • Immune system process
    (GO:0002376)
  • Maintenance of protein location
    (GO:0045185)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell degranulation
    (GO:0043322)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Nucleus
    (GO:0005634)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of defense response to bacterium
    (GO:1900426)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of innate immune response
    (GO:0045089)
  • Positive regulation of interleukin-1 production
    (GO:0032732)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of oxidoreductase activity
    (GO:0051353)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein binding
    (GO:0005515)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Receptor clustering
    (GO:0043113)
  • Regulation of natural killer cell differentiation
    (GO:0032823)
  • Regulation of t-helper 17 type immune response
    (GO:2000316)
  • Regulation of t cell chemotaxis
    (GO:0010819)
  • Regulation of t cell differentiation in thymus
    (GO:0033081)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Signaling receptor binding
    (GO:0005102)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)

Other Information

Genular Protein ID: 3845665322

Symbol: LEG9_MOUSE

Name: Galectin-9

UniProtKB Accession Codes:

O08573 O08572 Q3UKE5 Q99L83

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 6 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 9038233

Title: Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.

PubMed ID: 9038233

DOI: 10.1074/jbc.272.9.6078

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9153289

Title: Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

PubMed ID: 9153289

DOI: 10.1172/jci119429

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20937702

Title: Tim3 binding to galectin-9 stimulates antimicrobial immunity.

PubMed ID: 20937702

DOI: 10.1084/jem.20100687

PubMed ID: 21670307

Title: Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.

PubMed ID: 21670307

DOI: 10.1073/pnas.1017954108

PubMed ID: 23242525

Title: Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.

PubMed ID: 23242525

DOI: 10.1095/biolreprod.112.105460

PubMed ID: 23408620

Title: Galectin-9 functionally impairs natural killer cells in humans and mice.

PubMed ID: 23408620

DOI: 10.1128/jvi.01085-12

PubMed ID: 25065622

Title: Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells.

PubMed ID: 25065622

DOI: 10.1016/j.immuni.2014.06.011

PubMed ID: 25158758

Title: Astrocyte galectin-9 potentiates microglial TNF secretion.

PubMed ID: 25158758

DOI: 10.1186/s12974-014-0144-0

PubMed ID: 16990264

Title: Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.

PubMed ID: 16990264

DOI: 10.1074/jbc.m606648200

Sequence Information:

  • Length: 353
  • Mass: 40036
  • Checksum: B54036F6E280C531
  • Sequence:
    • MALFSAQSPY INPIIPFTGP IQGGLQEGLQ VTLQGTTKSF AQRFVVNFQN SFNGNDIAFH 
FNPRFEEGGY VVCNTKQNGQ WGPEERKMQM PFQKGMPFEL CFLVQRSEFK VMVNKKFFVQ 
YQHRVPYHLV DTIAVSGCLK LSFITFQNSA APVQHVFSTL QFSQPVQFPR TPKGRKQKTQ 
NFRPAHQAPM AQTTIHMVHS TPGQMFSTPG IPPVVYPTPA YTIPFYTPIP NGLYPSKSIM 
ISGNVLPDAT RFHINLRCGG DIAFHLNPRF NENAVVRNTQ INNSWGQEER SLLGRMPFSR 
GQSFSVWIIC EGHCFKVAVN GQHMCEYYHR LKNLQDINTL EVAGDIQLTH VQT

Genular Protein ID: 326490351

Symbol: G3X9T7_MOUSE

Name: N/A

UniProtKB Accession Codes:

G3X9T7

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 InterPro 3 KEGG 1 MGI 2 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 353
  • Mass: 40022
  • Checksum: A9BB311FEC7BC2D1
  • Sequence:
    • MALFSAQSPY INPIIPFTGP IQGGLQEGLQ VTLQGTTKSF AQRFVVNFQN SFNGNDIAFH 
FNPRFEEGGY VVCNTKQNGQ WGPEERKMQM PFQKGMPFEL CFLVQRSEFK VMVNKKFFVQ 
YQHRVPYHLV DTIAVSGCLK LSFITFQNSA APVQHVFSTV QFSQPVQFPR TPKGRKQKTQ 
NFRPAHQAPM AQTTIHMVHS TPGQMFSTPG IPPVVYPTPA YTIPFYTPIP NGLYPSKSIM 
ISGNVLPDAT RFHINLRCGG DIAFHLNPRF NENAVVRNTQ INNSWGQEER SLLGRMPFSR 
GQSFSVWIIC EGHCFKVAVN GQHMCEYYHR LKNLQDINTL EVAGDIQLTH VQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.