Genular: Defining Cellular Identity and Function

Details for: Lhx2

Gene ID: 16870

Symbol: Lhx2

Ensembl ID: ENSMUSG00000000247

Description: LIM homeobox protein 2

Associated with

Anatomical structure formation involved in morphogenesis
(GO:0048646)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Brain development
(GO:0007420)
Cerebral cortex development
(GO:0021987)
Chromatin binding
(GO:0003682)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dorsal/ventral pattern formation
(GO:0009953)
Hair follicle development
(GO:0001942)
Intracellular anatomical structure
(GO:0005622)
Maintenance of epithelial cell apical/basal polarity
(GO:0045199)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of transcription regulatory region dna binding
(GO:2000678)
Nervous system development
(GO:0007399)
Neural tube closure
(GO:0001843)
Neurogenesis
(GO:0022008)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory bulb development
(GO:0021772)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Retina development in camera-type eye
(GO:0060041)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Transcription factor binding
(GO:0008134)

Other Information

Proteins

LIM/homeobox protein Lhx2
F6Z9H5_MOUSE

Genular Protein ID: 4090509760

Symbol: LHX2_MOUSE

Name: LIM/homeobox protein Lhx2

UniProtKB Accession Codes:

Q9Z0S2

Database IDs:

Citations:

PubMed ID: 10051612

Title: Conservation of the expression and function of apterous orthologs in Drosophila and mammals.

PubMed ID: 10051612

DOI: 10.1073/pnas.96.5.2165

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10593900

Title: MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.

PubMed ID: 10593900

DOI: 10.1074/jbc.274.51.36159

PubMed ID: 24643061

Title: Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.

PubMed ID: 24643061

DOI: 10.1371/journal.pone.0092105

Sequence Information:

Length: 406
Mass: 44419
Checksum: FE7B4E76454D6A90
Sequence:

MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA ALCAGCGGKI 
SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI YCKEDYYRRF SVQRCARCHL 
GISASEMVMR ARDLVYHLNC FTCTTCNKML TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH 
FNHADVAAAA AAAAAAKSAG LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY 
NAALSCNEND AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA 
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA SELSNASLSP 
SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT TLTNLF

Genular Protein ID: 837792626

Symbol: F6Z9H5_MOUSE

Name: N/A

UniProtKB Accession Codes:

F6Z9H5

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 365
Mass: 40009
Checksum: 640E6138C06E520F
Sequence:

MPSISSDRAA LCAGCGGKIS DRYYLLAVDK QWHMRCLKCC ECKLNLESEL TCFSKDGSIY 
CKEDYYRRFS VQRCARCHLG ISASEMVMRA RDLVYHLNCF TCTTCNKMLT TGDHFGMKDS 
LVYCRLHFEA LLQGEYPAHF NHADVAAAAA AAAAAKSAGL GSAGANPLGL PYYNGVGTVQ 
KGRPRKRKSP GPGADLAAYN AALSCNENDA EHLDRDQPYP SSQKTKRMRT SFKHHQLRTM 
KSYFAINHNP DAKDLKQLAQ KTGLTKRVLQ VWFQNARAKF RRNLLRQENT GVDKTSDATL 
QTGTPSGPAS ELSNASLSPS STPTTLTDLT SPTLPTVTSV LTSVPGNLEG HEPHSPSQTT 
LTNLF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lhx2

Associated with

Other Information

Conservation of the expression and function of apterous orthologs in Drosophila and mammals. PubMed ID: 10051612

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. PubMed ID: 10593900