Details for: Lhx3

Gene ID: 16871

Symbol: Lhx3

Ensembl ID: ENSMUSG00000026934

Description: LIM homeobox protein 3

Associated with

  • Apoptotic process
    (GO:0006915)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dorsal/ventral pattern formation
    (GO:0009953)
  • Intracellular anatomical structure
    (GO:0005622)
  • Medial motor column neuron differentiation
    (GO:0021526)
  • Metal ion binding
    (GO:0046872)
  • Motor neuron axon guidance
    (GO:0008045)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pituitary gland development
    (GO:0021983)
  • Placenta development
    (GO:0001890)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prolactin secreting cell differentiation
    (GO:0060127)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Somatotropin secreting cell differentiation
    (GO:0060126)
  • Spinal cord association neuron differentiation
    (GO:0021527)
  • Spinal cord motor neuron cell fate specification
    (GO:0021520)
  • Thyroid-stimulating hormone-secreting cell differentiation
    (GO:0060129)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription regulator complex
    (GO:0005667)
  • Ventral spinal cord interneuron specification
    (GO:0021521)

Other Information

Genular Protein ID: 2375855172

Symbol: LHX3_MOUSE

Name: LIM/homeobox protein Lhx3

UniProtKB Accession Codes:

P50481 A2ALD9 Q61800 Q61801

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 3 CORUM 1 CTD 1 DNASU 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 2 SAM 1 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7811383

Title: The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary.

PubMed ID: 7811383

DOI: 10.1089/dna.1994.13.1163

PubMed ID: 7708713

Title: P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

PubMed ID: 7708713

DOI: 10.1073/pnas.92.7.2720

PubMed ID: 7626792

Title: Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues.

PubMed ID: 7626792

DOI: 10.1002/aja.1002020405

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9192866

Title: A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.

PubMed ID: 9192866

DOI: 10.1101/gad.11.11.1370

PubMed ID: 10593900

Title: MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.

PubMed ID: 10593900

DOI: 10.1074/jbc.274.51.36159

PubMed ID: 12150931

Title: LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

PubMed ID: 12150931

DOI: 10.1016/s0092-8674(02)00823-1

PubMed ID: 18539116

Title: A regulatory network to segregate the identity of neuronal subtypes.

PubMed ID: 18539116

DOI: 10.1016/j.devcel.2008.03.021

PubMed ID: 18583962

Title: Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.

PubMed ID: 18583962

DOI: 10.1038/emboj.2008.123

Sequence Information:

  • Length: 400
  • Mass: 44010
  • Checksum: AD7A9453CFACC730
  • Sequence:
    • MLLEAELDCH RERPGAPGAS ALCTFSRTPE IPMCAGCDQH ILDRFILKAL DRHWHSKCLK 
CSDCHVPLAE RCFSRGESVY CKDDFFKRFG TKCAACQLGI PPTQVVRRAQ DFVYHLHCFA 
CVVCKRQLAT GDEFYLMEDS RLVCKADYET AKQREAEATA KRPRTTITAK QLETLKSAYN 
TSPKPARHVR EQLSSETGLD MRVVQVWFQN RRAKEKRLKK DAGRQRWGQY FRNMKRSRGS 
SKSDKDSIQE GQDSDAEVSF TDEPSMADMG PANGLYSSLG EPAPALGRPV GGLGSFTLDH 
GGLTGPEQYR ELRPGSPYGI PPSPAAPQSL PGPQPLLSSL VYPDTNLSLV PSGPPGGPPP 
MRVLAGNGPS SDLSTESSSG YPDFPASPAS WLDEVDHAQF

Genular Protein ID: 856375095

Symbol: A2ALD8_MOUSE

Name: N/A

UniProtKB Accession Codes:

A2ALD8

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 3 ExpressionAtlas 1 GO 8 Gene3D 2 HOGENOM 1 InterPro 4 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 402
  • Mass: 44289
  • Checksum: 45942CCDADC72080
  • Sequence:
    • MEARGELDPS RESAGGDLLL ALLARRADLR REIPMCAGCD QHILDRFILK ALDRHWHSKC 
LKCSDCHVPL AERCFSRGES VYCKDDFFKR FGTKCAACQL GIPPTQVVRR AQDFVYHLHC 
FACVVCKRQL ATGDEFYLME DSRLVCKADY ETAKQREAEA TAKRPRTTIT AKQLETLKSA 
YNTSPKPARH VREQLSSETG LDMRVVQVWF QNRRAKEKRL KKDAGRQRWG QYFRNMKRSR 
GSSKSDKDSI QEGQDSDAEV SFTDEPSMAD MGPANGLYSS LGEPAPALGR PVGGLGSFTL 
DHGGLTGPEQ YRELRPGSPY GIPPSPAAPQ SLPGPQPLLS SLVYPDTNLS LVPSGPPGGP 
PPMRVLAGNG PSSDLSTESS SGYPDFPASP ASWLDEVDHA QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.