Genular: Defining Cellular Identity and Function

Details for: Lif

Gene ID: 16878

Symbol: Lif

Ensembl ID: ENSMUSG00000034394

Description: leukemia inhibitory factor

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Il-6-type cytokine receptor ligand interactions
(R-MMU-6788467)
Immune system
(R-MMU-168256)
Interleukin-6 family signaling
(R-MMU-6783589)
Signaling by interleukins
(R-MMU-449147)
Animal organ regeneration
(GO:0031100)
Astrocyte differentiation
(GO:0048708)
Blood vessel remodeling
(GO:0001974)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Cytokine activity
(GO:0005125)
Cytosol
(GO:0005829)
Decidualization
(GO:0046697)
Embryo implantation
(GO:0007566)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast proliferation
(GO:0048144)
Gene expression
(GO:0010467)
Growth factor activity
(GO:0008083)
Immune response
(GO:0006955)
Leukemia inhibitory factor receptor binding
(GO:0005146)
Leukemia inhibitory factor signaling pathway
(GO:0048861)
Lung alveolus development
(GO:0048286)
Lung development
(GO:0030324)
Lung lobe morphogenesis
(GO:0060463)
Lung vasculature development
(GO:0060426)
Maternal process involved in female pregnancy
(GO:0060135)
Meiotic nuclear division
(GO:0140013)
Muscle organ morphogenesis
(GO:0048644)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of hormone secretion
(GO:0046888)
Negative regulation of meiotic nuclear division
(GO:0045835)
Neuron development
(GO:0048666)
Positive regulation of astrocyte differentiation
(GO:0048711)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of corticotropin secretion
(GO:0051461)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
(GO:0072108)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-serine phosphorylation of stat protein
(GO:0033141)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Receptor signaling pathway via stat
(GO:0097696)
Regulation of cell differentiation
(GO:0045595)
Regulation of metanephric nephron tubule epithelial cell differentiation
(GO:0072307)
Regulation of rna polymerase ii regulatory region sequence-specific dna binding
(GO:1903025)
Response to hypoxia
(GO:0001666)
Retina development in camera-type eye
(GO:0060041)
Signaling receptor binding
(GO:0005102)
Somatic stem cell population maintenance
(GO:0035019)
Spongiotrophoblast differentiation
(GO:0060708)
Stem cell differentiation
(GO:0048863)
Transdifferentiation
(GO:0060290)
Trophoblast giant cell differentiation
(GO:0060707)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Leukemia inhibitory factor
F8WH42_MOUSE

Genular Protein ID: 2799661587

Symbol: LIF_MOUSE

Name: Leukemia inhibitory factor

UniProtKB Accession Codes:

P09056

Database IDs:

Citations:

PubMed ID: 3186448

Title: Complete sequence of murine myeloid leukaemia inhibitory factor (LIF).

PubMed ID: 3186448

DOI: 10.1093/nar/16.20.9857

PubMed ID: 1692837

Title: Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

PubMed ID: 1692837

DOI: 10.1016/s0021-9258(19)38963-x

PubMed ID: 10438970

Title: Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.

PubMed ID: 10438970

PubMed ID: 3127201

Title: Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).

PubMed ID: 3127201

DOI: 10.1002/j.1460-2075.1987.tb02742.x

PubMed ID: 3147726

Title: Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cells.

PubMed ID: 3147726

PubMed ID: 2475312

Title: Genomic cloning and heterologous expression of human differentiation-stimulating factor.

PubMed ID: 2475312

DOI: 10.1089/dna.1.1989.8.351

PubMed ID: 8422244

Title: The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications.

PubMed ID: 8422244

DOI: 10.1006/bbrc.1993.1004

PubMed ID: 8020098

Title: The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding.

PubMed ID: 8020098

DOI: 10.1016/0092-8674(94)90449-9

PubMed ID: 9254611

Title: Solution dynamics and secondary structure of murine leukemia inhibitory factor: a four-helix cytokine with a rigid CD loop.

PubMed ID: 9254611

DOI: 10.1021/bi970665m

PubMed ID: 9593715

Title: Solution structure of leukemia inhibitory factor.

PubMed ID: 9593715

DOI: 10.1074/jbc.273.22.13738

Sequence Information:

Length: 203
Mass: 22287
Checksum: F5C65EF11A67A835
Sequence:

MKVLAAGIVP LLLLVLHWKH GAGSPLPITP VNATCAIRHP CHGNLMNQIK NQLAQLNGSA 
NALFISYYTA QGEPFPNNVE KLCAPNMTDF PSFHGNGTEK TKLVELYRMV AYLSASLTNI 
TRDQKVLNPT AVSLQVKLNA TIDVMRGLLS NVLCRLCNKY RVGHVDVPPV PDHSDKEAFQ 
RKKLGCQLLG TYKQVISVVV QAF

Genular Protein ID: 2405721732

Symbol: F8WH42_MOUSE

Name: N/A

UniProtKB Accession Codes:

F8WH42

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 158
Mass: 17574
Checksum: DD867142A62F322E
Sequence:

MNQIKNQLAQ LNGSANALFI SYYTAQGEPF PNNVEKLCAP NMTDFPSFHG NGTEKTKLVE 
LYRMVAYLSA SLTNITRDQK VLNPTAVSLQ VKLNATIDVM RGLLSNVLCR LCNKYRVGHV 
DVPPVPDHSD KEAFQRKKLG CQLLGTYKQV ISVVVQAF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lif

Associated with

Other Information

Complete sequence of murine myeloid leukaemia inhibitory factor (LIF). PubMed ID: 3186448

Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions. PubMed ID: 1692837

Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. PubMed ID: 10438970

Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). PubMed ID: 3127201

Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cells. PubMed ID: 3147726

Genomic cloning and heterologous expression of human differentiation-stimulating factor. PubMed ID: 2475312

The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications. PubMed ID: 8422244

The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. PubMed ID: 8020098

Solution dynamics and secondary structure of murine leukemia inhibitory factor: a four-helix cytokine with a rigid CD loop. PubMed ID: 9254611

Solution structure of leukemia inhibitory factor. PubMed ID: 9593715

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303