Genular: Defining Cellular Identity and Function

Details for: Lmna

Gene ID: 16905

Symbol: Lmna

Ensembl ID: ENSMUSG00000028063

Description: lamin A

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Breakdown of the nuclear lamina
(R-MMU-352238)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Depolymerization of the nuclear lamina
(R-MMU-4419969)
Initiation of nuclear envelope (ne) reformation
(R-MMU-2995383)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Nuclear envelope breakdown
(R-MMU-2980766)
Programmed cell death
(R-MMU-5357801)
Cellular senescence
(GO:0090398)
Dna double-strand break attachment to nuclear envelope
(GO:1990683)
Establishment of cell polarity
(GO:0030010)
Establishment or maintenance of microtubule cytoskeleton polarity
(GO:0030951)
Heterochromatin formation
(GO:0031507)
Identical protein binding
(GO:0042802)
Intermediate filament
(GO:0005882)
Lamin filament
(GO:0005638)
Muscle organ development
(GO:0007517)
Negative regulation of adipose tissue development
(GO:1904178)
Negative regulation of cardiac muscle hypertrophy in response to stress
(GO:1903243)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of mesenchymal cell proliferation
(GO:0072201)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Nuclear envelope
(GO:0005635)
Nuclear envelope organization
(GO:0006998)
Nuclear lamina
(GO:0005652)
Nuclear matrix
(GO:0016363)
Nuclear membrane
(GO:0031965)
Nuclear migration
(GO:0007097)
Nuclear pore localization
(GO:0051664)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Nucleus organization
(GO:0006997)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of osteoblast differentiation
(GO:0045669)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein localization
(GO:0008104)
Protein localization to nuclear envelope
(GO:0090435)
Protein localization to nucleus
(GO:0034504)
Protein phosphatase 1 binding
(GO:0008157)
Regulation of cell migration
(GO:0030334)
Regulation of protein localization to nucleus
(GO:1900180)
Regulation of protein stability
(GO:0031647)
Regulation of telomere maintenance
(GO:0032204)
Site of double-strand break
(GO:0035861)
Structural constituent of cytoskeleton
(GO:0005200)
Ventricular cardiac muscle cell development
(GO:0055015)

Other Information

Proteins

Prelamin-A/C

Genular Protein ID: 4020600748

Symbol: LMNA_MOUSE

Name: Prelamin-A/C

UniProtKB Accession Codes:

P48678 B3RH23 B3RH24 P11516 P97859 Q3TIH0 Q3TTS8 Q3U733 Q3U7I5 Q3UCA0 Q3UCJ8 Q3UCU3 Q91WF2 Q9DC21

Database IDs:

Citations:

PubMed ID: 7781761

Title: Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins.

PubMed ID: 7781761

DOI: 10.1016/0014-5793(95)00453-g

PubMed ID: 2719959

Title: Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence.

PubMed ID: 2719959

DOI: 10.1016/0167-4781(89)90179-6

PubMed ID: 8187835

Title: Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice.

PubMed ID: 8187835

DOI: 10.1006/excr.1994.1164

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7916626

Title: Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence.

PubMed ID: 7916626

DOI: 10.1016/0167-4781(93)90072-l

PubMed ID: 2583287

Title: Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina.

PubMed ID: 2583287

DOI: 10.1016/0014-5793(89)81584-4

PubMed ID: 1959608

Title: Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing.

PubMed ID: 1959608

DOI: 10.1016/0014-5793(91)80868-4

PubMed ID: 10579712

Title: Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy.

PubMed ID: 10579712

DOI: 10.1083/jcb.147.5.913

PubMed ID: 11799477

Title: Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse.

PubMed ID: 11799477

DOI: 10.1086/339274

PubMed ID: 11929849

Title: A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies.

PubMed ID: 11929849

DOI: 10.1093/hmg/11.7.769

PubMed ID: 16380439

Title: Coupling of the nucleus and cytoplasm: role of the LINC complex.

PubMed ID: 16380439

DOI: 10.1083/jcb.200509124

PubMed ID: 16648470

Title: SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

PubMed ID: 16648470

DOI: 10.1128/mcb.26.10.3738-3751.2006

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 17652517

Title: HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.

PubMed ID: 17652517

DOI: 10.1073/pnas.0704212104

PubMed ID: 18606848

Title: Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies.

PubMed ID: 18606848

DOI: 10.1083/jcb.200712124

PubMed ID: 18230648

Title: LUMA interacts with emerin and influences its distribution at the inner nuclear membrane.

PubMed ID: 18230648

DOI: 10.1242/jcs.019281

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19124654

Title: Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy.

PubMed ID: 19124654

DOI: 10.1083/jcb.200811035

PubMed ID: 19843581

Title: Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.

PubMed ID: 19843581

DOI: 10.1242/jcs.057075

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19933576

Title: Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.

PubMed ID: 19933576

DOI: 10.1074/jbc.m109.071910

PubMed ID: 21498514

Title: Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP).

PubMed ID: 21498514

DOI: 10.1074/jbc.m110.165548

PubMed ID: 21982926

Title: Lamin A/C deficiency is associated with fat infiltration of muscle and bone.

PubMed ID: 21982926

DOI: 10.1016/j.mad.2011.09.004

PubMed ID: 21547077

Title: Decreased bone formation and osteopenia in lamin a/c-deficient mice.

PubMed ID: 21547077

DOI: 10.1371/journal.pone.0019313

PubMed ID: 22349700

Title: Samp1 is a component of TAN lines and is required for nuclear movement.

PubMed ID: 22349700

DOI: 10.1242/jcs.087049

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23695662

Title: Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.

PubMed ID: 23695662

DOI: 10.1038/ncomms2885

PubMed ID: 23535822

Title: Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2alpha.

PubMed ID: 23535822

DOI: 10.1093/hmg/ddt135

PubMed ID: 26436652

Title: Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.

PubMed ID: 26436652

DOI: 10.1172/jci82423

Sequence Information:

Length: 665
Mass: 74238
Checksum: 5434F574803FCB15
Sequence:

METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR 
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN 
TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK 
KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR 
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID 
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ 
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK 
LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT 
YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INSTGEEVAM 
RKLVRSLTMV EDNEDDDEDG EELLHHHRGS HCSGSGDPAE YNLRSRTVLC GTCGQPADKA 
AGGAGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG NSSPRSQSSQ 
NCSIM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lmna

Associated with

Other Information

Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins. PubMed ID: 7781761

Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence. PubMed ID: 2719959

Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice. PubMed ID: 8187835

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence. PubMed ID: 7916626

Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina. PubMed ID: 2583287

Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing. PubMed ID: 1959608

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. PubMed ID: 10579712

Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. PubMed ID: 11799477

A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. PubMed ID: 11929849

Coupling of the nucleus and cytoplasm: role of the LINC complex. PubMed ID: 16380439

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. PubMed ID: 16648470

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. PubMed ID: 17652517

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. PubMed ID: 18606848

LUMA interacts with emerin and influences its distribution at the inner nuclear membrane. PubMed ID: 18230648

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. PubMed ID: 19124654

Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. PubMed ID: 19843581

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. PubMed ID: 19933576

Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP). PubMed ID: 21498514

Lamin A/C deficiency is associated with fat infiltration of muscle and bone. PubMed ID: 21982926

Decreased bone formation and osteopenia in lamin a/c-deficient mice. PubMed ID: 21547077

Samp1 is a component of TAN lines and is required for nuclear movement. PubMed ID: 22349700

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. PubMed ID: 23695662

Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2alpha. PubMed ID: 23535822

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. PubMed ID: 26436652