Genular: Defining Cellular Identity and Function

Details for: Psmb8

Gene ID: 16913

Symbol: Psmb8

Ensembl ID: ENSMUSG00000024338

Description: proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Assembly of the pre-replicative complex
(R-MMU-68867)
Asymmetric localization of pcp proteins
(R-MMU-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-MMU-174084)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cellular response to hypoxia
(R-MMU-1234174)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-MMU-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Degradation of axin
(R-MMU-4641257)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of dvl
(R-MMU-4641258)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Deubiquitination
(R-MMU-5688426)
Dna replication
(R-MMU-69306)
Dna replication pre-initiation
(R-MMU-69002)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Intracellular signaling by second messengers
(R-MMU-9006925)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of polyamines
(R-MMU-351202)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Mitotic anaphase
(R-MMU-68882)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Neddylation
(R-MMU-8951664)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
P53-independent g1/s dna damage checkpoint
(R-MMU-69613)
Pcp/ce pathway
(R-MMU-4086400)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Pten regulation
(R-MMU-6807070)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Regulation of ornithine decarboxylase (odc)
(R-MMU-350562)
Regulation of ras by gaps
(R-MMU-5658442)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tcr signaling
(R-MMU-202403)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Transport of small molecules
(R-MMU-382551)
Ub-specific processing proteases
(R-MMU-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-MMU-75815)
Uch proteinases
(R-MMU-5689603)

Other Information

Proteins

Proteasome subunit beta type-8

Genular Protein ID: 833634790

Symbol: PSB8_MOUSE

Name: Proteasome subunit beta type-8

UniProtKB Accession Codes:

P28063 Q3UK42 Q64300 Q792S8 Q7TMX9 Q91VH7

Database IDs:

Citations:

PubMed ID: 1633842

Title: Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA.

PubMed ID: 1633842

DOI: 10.1016/0014-5793(92)80420-l

PubMed ID: 8344725

Title: Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes.

PubMed ID: 8344725

DOI: 10.1007/bf00210482

PubMed ID: 8406612

Title: Genomic organization and tissue expression of the mouse proteasome gene Lmp-7.

PubMed ID: 8406612

DOI: 10.1007/bf00184520

PubMed ID: 8854085

Title: Molecular and serological analysis of polymorphisms in the murine major histocompatibility complex-encoded proteasome subunits, LMP-2 and LMP-7.

PubMed ID: 8854085

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8066463

Title: MHC class I expression in mice lacking the proteasome subunit LMP-7.

PubMed ID: 8066463

DOI: 10.1126/science.8066463

PubMed ID: 15371230

Title: Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets.

PubMed ID: 15371230

DOI: 10.1080/15287390490483827

PubMed ID: 15907481

Title: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.

PubMed ID: 15907481

DOI: 10.1016/j.febslet.2005.04.012

PubMed ID: 17142736

Title: Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes.

PubMed ID: 17142736

DOI: 10.4049/jimmunol.177.12.8393

PubMed ID: 16452686

Title: Regulation of the neuronal proteasome by Zif268 (Egr1).

PubMed ID: 16452686

DOI: 10.1523/jneurosci.4199-05.2006

PubMed ID: 16857966

Title: Mapping the murine cardiac 26S proteasome complexes.

PubMed ID: 16857966

DOI: 10.1161/01.res.0000237386.98506.f7

PubMed ID: 19525961

Title: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

PubMed ID: 19525961

DOI: 10.1038/nm.1978

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21881205

Title: A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.

PubMed ID: 21881205

DOI: 10.1172/jci58414

PubMed ID: 23706739

Title: Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

PubMed ID: 23706739

DOI: 10.1016/j.cell.2013.04.032

PubMed ID: 22341445

Title: Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

PubMed ID: 22341445

DOI: 10.1016/j.cell.2011.12.030

Sequence Information:

Length: 276
Mass: 30260
Checksum: D9FCCF3EF83CD3C3
Sequence:

MALLDLCGAA RGQRPEWAAL DAGSGGRSDP GHYSFSAQAP ELALPRGMQP TAFLRSFGGD 
QERNVQIEMA HGTTTLAFKF QHGVIVAVDS RATAGSYISS LRMNKVIEIN PYLLGTMSGC 
AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMML QYRGMGLSMG SMICGWDKKG 
PGLYYVDDNG TRLSGQMFST GSGNTYAYGV MDSGYRQDLS PEEAYDLGRR AIAYATHRDN 
YSGGVVNMYH MKEDGWVKVE SSDVSDLLYK YGEAAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Psmb8

Associated with

Other Information

Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA. PubMed ID: 1633842

Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes. PubMed ID: 8344725

Genomic organization and tissue expression of the mouse proteasome gene Lmp-7. PubMed ID: 8406612

Molecular and serological analysis of polymorphisms in the murine major histocompatibility complex-encoded proteasome subunits, LMP-2 and LMP-7. PubMed ID: 8854085

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MHC class I expression in mice lacking the proteasome subunit LMP-7. PubMed ID: 8066463

Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets. PubMed ID: 15371230

IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. PubMed ID: 15907481

Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes. PubMed ID: 17142736

Regulation of the neuronal proteasome by Zif268 (Egr1). PubMed ID: 16452686

Mapping the murine cardiac 26S proteasome complexes. PubMed ID: 16857966

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. PubMed ID: 19525961

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans. PubMed ID: 21881205

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. PubMed ID: 23706739

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. PubMed ID: 22341445