Genular: Defining Cellular Identity and Function

Details for: Lox

Gene ID: 16948

Symbol: Lox

Ensembl ID: ENSMUSG00000024529

Description: lysyl oxidase

Associated with

Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Collagen formation
(R-MMU-1474290)
Crosslinking of collagen fibrils
(R-MMU-2243919)
Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Aorta development
(GO:0035904)
Ascending aorta development
(GO:0035905)
Blood vessel development
(GO:0001568)
Blood vessel morphogenesis
(GO:0048514)
Bone mineralization
(GO:0030282)
Cell chemotaxis
(GO:0060326)
Cellular response to chemokine
(GO:1990869)
Cellular response to organic substance
(GO:0071310)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen fibril organization
(GO:0030199)
Collagen trimer
(GO:0005581)
Connective tissue development
(GO:0061448)
Copper ion binding
(GO:0005507)
Descending aorta development
(GO:0035906)
Dna biosynthetic process
(GO:0071897)
Elastic fiber assembly
(GO:0048251)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heart development
(GO:0007507)
Lung development
(GO:0030324)
Metal ion binding
(GO:0046872)
Molecular adaptor activity
(GO:0060090)
Muscle cell cellular homeostasis
(GO:0046716)
Muscle cell development
(GO:0055001)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Osteoblast differentiation
(GO:0001649)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor
(GO:0016641)
Peptidyl-lysine oxidation
(GO:0018057)
Platelet-derived growth factor receptor-beta signaling pathway
(GO:0035791)
Protein-lysine 6-oxidase activity
(GO:0004720)
Protein binding
(GO:0005515)
Protein oxidation
(GO:0018158)
Regulation of apoptotic process
(GO:0042981)
Regulation of bone development
(GO:1903010)
Regulation of gene expression
(GO:0010468)
Regulation of megakaryocyte differentiation
(GO:0045652)
Regulation of platelet-derived growth factor receptor-beta signaling pathway
(GO:2000586)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of receptor binding
(GO:1900120)
Regulation of striated muscle tissue development
(GO:0016202)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to hormone
(GO:0009725)
Response to steroid hormone
(GO:0048545)
Small molecule binding
(GO:0036094)

Other Information

Proteins

Protein-lysine 6-oxidase
Q3TP83_MOUSE

Genular Protein ID: 1579541321

Symbol: LYOX_MOUSE

Name: Protein-lysine 6-oxidase

UniProtKB Accession Codes:

P28301

Database IDs:

Citations:

PubMed ID: 1678898

Title: Lysyl oxidase and rrg messenger RNA.

PubMed ID: 1678898

DOI: 10.1126/science.1678898

PubMed ID: 8100214

Title: Structure of the mouse lysyl oxidase gene.

PubMed ID: 8100214

DOI: 10.1006/geno.1993.1202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16251195

Title: The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers.

PubMed ID: 16251195

DOI: 10.1074/jbc.m506832200

PubMed ID: 20181949

Title: Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.

PubMed ID: 20181949

DOI: 10.1074/jbc.m109.088864

PubMed ID: 27432961

Title: Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.

PubMed ID: 27432961

DOI: 10.1073/pnas.1601442113

Sequence Information:

Length: 411
Mass: 46701
Checksum: DBC0563A9C0AEB52
Sequence:

MRFAWAVLLL GPLQLCPLLR CAPQTPREPP AAPGAWRQTI QWENNGQVFS LLSLGAQYQP 
QRRRDPSATA RRPDGDAASQ PRTPILLLRD NRTASTRART PSPSGVAAGR PRPAARHWFQ 
AGFSPSGARD GASRRAANRT ASPQPPQLSN LRPPSHIDRM VGDDPYNPYK YSDDNPYYNY 
YDTYERPRPG SRNRPGYGTG YFQYGLPDLV PDPYYIQAST YVQKMSMYNL RCAAEENCLA 
SSAYRADVRD YDHRVLLRFP QRVKNQGTSD FLPSRPRYSW EWHSCHQHYH SMDEFSHYDL 
LDANTQRRVA EGHKASFCLE DTSCDYGYHR RFACTAHTQG LSPGCYDTYA ADIDCQWIDI 
TDVQPGNYIL KVSVNPSYLV PESDYTNNVV RCDIRYTGHH AYASGCTISP Y

Genular Protein ID: 2489373645

Symbol: Q3TP83_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TP83

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 411
Mass: 46773
Checksum: 81C05639FF6AE831
Sequence:

MRFAWAVLLL GPLQLCPLLR CAPQTPREPP AAPGAWRQTI QWENNGQVFS LLSLGAQYQP 
QRRRDPSATA RRPDGDAASQ PRTPILLLRD NRTASTRART PSPSGVAAGR PRPAARHWFQ 
AGFSPSGARD GASRRAANRT ASPQPPQLSN LRPPSHIDRM VGDDPYNPYK YSDDNPYYNY 
YDTYERPRPG SRNRPGYGTG YFQYGLPDLV PDPYYIQAST YVQKMSMYNL RCAAEENCLA 
SSAYRADVRD YDHRVLLRFP QRVKNQGTSD FLPSRPRYSW EWHSCHQHYH SMDEFSHYDL 
LDANTQRRVA EGHKASFCLE DTSCDYGYHR RFACTAHTQG LSPECYDTYA ADIDCQWIDI 
TDVQPGNYIL KVSVNPSYLV PESDYTNNVV RCDIRYTGHH AYASGCTISP Y

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lox

Associated with

Other Information

Lysyl oxidase and rrg messenger RNA. PubMed ID: 1678898

Structure of the mouse lysyl oxidase gene. PubMed ID: 8100214

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. PubMed ID: 16251195

Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. PubMed ID: 20181949

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. PubMed ID: 27432961

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073