Genular: Defining Cellular Identity and Function

Details for: Loxl3

Gene ID: 16950

Symbol: Loxl3

Ensembl ID: ENSMUSG00000000693

Description: lysyl oxidase-like 3

Associated with

Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Collagen formation
(R-MMU-1474290)
Crosslinking of collagen fibrils
(R-MMU-2243919)
Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen fibril organization
(GO:0030199)
Copper ion binding
(GO:0005507)
Cytoplasm
(GO:0005737)
Epithelial to mesenchymal transition
(GO:0001837)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Fibronectin fibril organization
(GO:1905590)
Inflammatory response
(GO:0006954)
Lung development
(GO:0030324)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of t-helper 17 cell lineage commitment
(GO:2000329)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor
(GO:0016641)
Peptidyl-lysine oxidation
(GO:0018057)
Positive regulation of integrin-mediated signaling pathway
(GO:2001046)
Protein-lysine 6-oxidase activity
(GO:0004720)
Roof of mouth development
(GO:0060021)
Somite development
(GO:0061053)
Spinal cord development
(GO:0021510)

Other Information

Proteins

LOXL3_MOUSE

Genular Protein ID: 2672042696

Symbol: LOXL3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z175 Q91VN8 Q9JJ39

Database IDs:

Citations:

PubMed ID: 9927484

Title: Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13.

PubMed ID: 9927484

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26307084

Title: Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice.

PubMed ID: 26307084

DOI: 10.1093/hmg/ddv333

PubMed ID: 26954549

Title: Localized LoxL3-dependent fibronectin oxidation regulates myofiber stretch and integrin-mediated adhesion.

PubMed ID: 26954549

DOI: 10.1016/j.devcel.2016.02.009

PubMed ID: 28065600

Title: Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation.

PubMed ID: 28065600

DOI: 10.1016/j.molcel.2016.12.002

PubMed ID: 27645581

Title: Loss of lysyl oxidase-like 3 attenuates embryonic lung development in mice.

PubMed ID: 27645581

DOI: 10.1038/srep33856

Sequence Information:

Length: 754
Mass: 83740
Checksum: C3BF60F77696914D
Sequence:

MRAVSVWYCC PWGLLLLHCL CSFSVGSPSP SISPEKKVGS QGLRFRLAGF PRKPYEGRVE 
IQRAGEWGTI CDDDFTLQAA HVLCRELGFT EATGWTHSAK YGPGTGRIWL DNLSCRGTEG 
SVTECASRGW GNSDCTHDED AGVICKDQRL PGFSDSNVIE VEHQLQVEEV RLRPAVEWGR 
RPLPVTEGLV EVRLPEGWSQ VCDKGWSAHN SHVVCGMLGF PGEKRVNMAF YRMLAQKKQH 
SFGLHSVACV GTEAHLSLCS LEFYRANDTT RCSGGNPAVV SCVLGPLYAT FTGQKKQQHS 
KPQGEARVRL KGGAHQGEGR VEVLKAGTWG TVCDRKWDLQ AASVVCRELG FGTAREALSG 
ARMGQGMGAI HLSEVRCSGQ EPSLWRCPSK NITAEDCSHS QDAGVRCNLP YTGVETKIRL 
SGGRSRYEGR VEVQIGIPGH LRWGLICGDD WGTLEAMVAC RQLGLGYANH GLQETWYWDS 
GNVTEVVMSG VRCTGSELSL NQCAHHSSHI TCKKTGTRFT AGVICSETAS DLLLHSALVQ 
ETAYIEDRPL HMLYCAAEEN CLASSARSAN WPYGHRRLLR FSSQIHNLGR ADFRPKAGRH 
SWVWHECHGH YHSMDIFTHY DILTPNGTKV AEGHKASFCL EDTECQEDVS KRYECANFGE 
QGITVGCWDL YRHDIDCQWI DITDVKPGNY ILQVVINPNF EVAESDFTNN AMKCNCKYDG 
HRIWVHNCHI GDAFSEEANR RFERYPGQTS NQIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Loxl3

Associated with

Other Information

Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13. PubMed ID: 9927484

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. PubMed ID: 26307084

Localized LoxL3-dependent fibronectin oxidation regulates myofiber stretch and integrin-mediated adhesion. PubMed ID: 26954549

Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation. PubMed ID: 28065600

Loss of lysyl oxidase-like 3 attenuates embryonic lung development in mice. PubMed ID: 27645581