Genular: Defining Cellular Identity and Function

Details for: Anxa1

Gene ID: 16952

Symbol: Anxa1

Ensembl ID: ENSMUSG00000024659

Description: annexin A1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Formyl peptide receptors bind formyl peptides and many other ligands
(R-MMU-444473)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Actin cytoskeleton organization
(GO:0030036)
Actin filament
(GO:0005884)
Adaptive immune response
(GO:0002250)
Alpha-beta t cell differentiation
(GO:0046632)
Apical plasma membrane
(GO:0016324)
Arachidonic acid secretion
(GO:0050482)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Cilium
(GO:0005929)
Collagen-containing extracellular matrix
(GO:0062023)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Dna/dna annealing activity
(GO:1990814)
Dna duplex unwinding
(GO:0032508)
Double-stranded dna helicase activity
(GO:0036121)
Endosome
(GO:0005768)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Granulocyte chemotaxis
(GO:0071621)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Insulin secretion
(GO:0030073)
Keratinocyte differentiation
(GO:0030216)
Lateral plasma membrane
(GO:0016328)
Lipid binding
(GO:0008289)
Localization
(GO:0051179)
Mast cell granule
(GO:0042629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial membrane
(GO:0031966)
Monocyte chemotaxis
(GO:0002548)
Motile cilium
(GO:0031514)
Myoblast migration involved in skeletal muscle regeneration
(GO:0014839)
Negative regulation of exocytosis
(GO:0045920)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of t-helper 2 cell differentiation
(GO:0045629)
Neutrophil activation
(GO:0042119)
Neutrophil clearance
(GO:0097350)
Neutrophil homeostasis
(GO:0001780)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptide cross-linking
(GO:0018149)
Phagocytosis
(GO:0006909)
Phosphatidylserine binding
(GO:0001786)
Phospholipase a2 inhibitor activity
(GO:0019834)
Phospholipase inhibitor activity
(GO:0004859)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of neutrophil apoptotic process
(GO:0033031)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of t-helper 1 cell differentiation
(GO:0045627)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of vesicle fusion
(GO:0031340)
Positive regulation of wound healing
(GO:0090303)
Prolactin secretion
(GO:0070459)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cell shape
(GO:0008360)
Regulation of hormone secretion
(GO:0046883)
Regulation of inflammatory response
(GO:0050727)
Regulation of interleukin-1 production
(GO:0032652)
Regulation of leukocyte migration
(GO:0002685)
Sarcolemma
(GO:0042383)
Signal transduction
(GO:0007165)
Single-stranded dna binding
(GO:0003697)
Single-stranded rna binding
(GO:0003727)

Other Information

Proteins

Annexin A1

Genular Protein ID: 1422617968

Symbol: ANXA1_MOUSE

Name: Annexin A1

UniProtKB Accession Codes:

P10107

Database IDs:

Citations:

PubMed ID: 2974946

Title: Mouse lipocortin I cDNA.

PubMed ID: 2974946

DOI: 10.1093/nar/16.24.11818

PubMed ID: 1676980

Title: Mouse lipocortin I gene structure and chromosomal assignment: gene duplication and the origins of a gene family.

PubMed ID: 1676980

DOI: 10.1016/0888-7543(91)90321-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2522299

Title: cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I.

PubMed ID: 2522299

DOI: 10.1016/0006-291x(89)92417-0

PubMed ID: 12475898

Title: Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.

PubMed ID: 12475898

DOI: 10.1096/fj.02-0239fje

PubMed ID: 14506282

Title: Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.

PubMed ID: 14506282

DOI: 10.1074/jbc.m307247200

PubMed ID: 17384087

Title: CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway.

PubMed ID: 17384087

DOI: 10.1152/ajplung.00014.2007

PubMed ID: 17948261

Title: Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells.

PubMed ID: 17948261

DOI: 10.1002/eji.200636792

PubMed ID: 18641677

Title: Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.

PubMed ID: 18641677

DOI: 10.1038/bjp.2008.252

PubMed ID: 18802107

Title: Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.

PubMed ID: 18802107

DOI: 10.4049/jimmunol.181.7.5035

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 19104500

Title: Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.

PubMed ID: 19104500

DOI: 10.1038/nri2470

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21245195

Title: Annexin A1 is a new functional linker between actin filaments and phagosomes during phagocytosis.

PubMed ID: 21245195

DOI: 10.1242/jcs.076208

PubMed ID: 23727357

Title: Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation.

PubMed ID: 23727357

DOI: 10.1016/j.cellsig.2013.05.028

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25664854

Title: Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

PubMed ID: 25664854

DOI: 10.1172/jci76693

Sequence Information:

Length: 346
Mass: 38734
Checksum: 9393A11B24191D3C
Sequence:

MAMVSEFLKQ ARFLENQEQE YVQAVKSYKG GPGSAVSPYP SFNVSSDVAA LHKAIMVKGV 
DEATIIDILT KRTNAQRQQI KAAYLQENGK PLDEVLRKAL TGHLEEVVLA MLKTPAQFDA 
DELRGAMKGL GTDEDTLIEI LTTRSNEQIR EINRVYREEL KRDLAKDITS DTSGDFRKAL 
LALAKGDRCQ DLSVNQDLAD TDARALYEAG ERRKGTDVNV FTTILTSRSF PHLRRVFQNY 
GKYSQHDMNK ALDLELKGDI EKCLTTIVKC ATSTPAFFAE KLYEAMKGAG TRHKALIRIM 
VSRSEIDMNE IKVFYQKKYG ISLCQAILDE TKGDYEKILV ALCGGN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Anxa1

Associated with

Other Information

Mouse lipocortin I cDNA. PubMed ID: 2974946

Mouse lipocortin I gene structure and chromosomal assignment: gene duplication and the origins of a gene family. PubMed ID: 1676980

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I. PubMed ID: 2522299

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. PubMed ID: 12475898

Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. PubMed ID: 14506282

CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. PubMed ID: 17384087

Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. PubMed ID: 17948261

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. PubMed ID: 18641677

Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. PubMed ID: 18802107

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. PubMed ID: 19104500

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Annexin A1 is a new functional linker between actin filaments and phagosomes during phagocytosis. PubMed ID: 21245195

Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation. PubMed ID: 23727357

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. PubMed ID: 25664854