Genular: Defining Cellular Identity and Function

Details for: Lpl

Gene ID: 16956

Symbol: Lpl

Ensembl ID: ENSMUSG00000015568

Description: lipoprotein lipase

Associated with

Assembly of active lpl and lipc lipase complexes
(R-MMU-8963889)
Metabolism
(R-MMU-1430728)
Metabolism of fat-soluble vitamins
(R-MMU-6806667)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Retinoid metabolism and transport
(R-MMU-975634)
Sensory perception
(R-MMU-9709957)
Transport of small molecules
(R-MMU-382551)
Visual phototransduction
(R-MMU-2187338)
1-acyl-2-lysophosphatidylserine acylhydrolase activity
(GO:0052740)
Apolipoprotein binding
(GO:0034185)
Calcium ion binding
(GO:0005509)
Carboxylic ester hydrolase activity
(GO:0052689)
Catalytic complex
(GO:1902494)
Cell surface
(GO:0009986)
Cellular response to fatty acid
(GO:0071398)
Cellular response to nutrient
(GO:0031670)
Cholesterol homeostasis
(GO:0042632)
Chylomicron
(GO:0042627)
Chylomicron remodeling
(GO:0034371)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid metabolic process
(GO:0006631)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
High-density lipoprotein particle remodeling
(GO:0034375)
Hydrolase activity
(GO:0016787)
Lipase activity
(GO:0016298)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Lipoprotein lipase activity
(GO:0004465)
Lipoprotein particle binding
(GO:0071813)
Low-density lipoprotein particle mediated signaling
(GO:0055096)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of cellular response to insulin stimulus
(GO:1900077)
Phosphatidylserine 1-acylhydrolase activity
(GO:0052739)
Phospholipase a1 activity
(GO:0008970)
Plasma membrane
(GO:0005886)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of chemokine (c-x-c motif) ligand 2 production
(GO:2000343)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of sequestering of triglyceride
(GO:0010890)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to bacterium
(GO:0009617)
Signaling receptor binding
(GO:0005102)
Triglyceride binding
(GO:0017129)
Triglyceride biosynthetic process
(GO:0019432)
Triglyceride catabolic process
(GO:0019433)
Triglyceride homeostasis
(GO:0070328)
Triglyceride lipase activity
(GO:0004806)
Very-low-density lipoprotein particle
(GO:0034361)
Very-low-density lipoprotein particle remodeling
(GO:0034372)

Other Information

Proteins

Lipoprotein lipase

Genular Protein ID: 3364754664

Symbol: LIPL_MOUSE

Name: Lipoprotein lipase

UniProtKB Accession Codes:

P11152 Q05956 Q542L4 Q9D3M9 Q9DCM8

Database IDs:

Citations:

PubMed ID: 2723548

Title: Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution.

PubMed ID: 2723548

PubMed ID: 1765386

Title: The structure of the mouse lipoprotein lipase gene: a B1 repetitive element is inserted into the 3' untranslated region of the mRNA.

PubMed ID: 1765386

DOI: 10.1016/0888-7543(91)90102-k

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1339460

Title: Adipogenesis in a myeloid supporting bone marrow stromal cell line.

PubMed ID: 1339460

DOI: 10.1002/jcb.240500112

PubMed ID: 1748295

Title: Cloning and characterization of the promoter of the murine lipoprotein lipase-encoding gene: structural and functional analysis.

PubMed ID: 1748295

DOI: 10.1016/0378-1119(91)90325-6

PubMed ID: 3597382

Title: The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family.

PubMed ID: 3597382

DOI: 10.1016/s0021-9258(18)47435-2

PubMed ID: 8675619

Title: Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

PubMed ID: 8675619

DOI: 10.1172/jci118319

PubMed ID: 17403372

Title: Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.

PubMed ID: 17403372

DOI: 10.1016/j.cmet.2007.02.002

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20620994

Title: GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.

PubMed ID: 20620994

DOI: 10.1016/j.cmet.2010.04.016

PubMed ID: 25066055

Title: The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism.

PubMed ID: 25066055

DOI: 10.1016/j.cmet.2014.06.015

PubMed ID: 24726386

Title: The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.

PubMed ID: 24726386

DOI: 10.1016/j.cmet.2014.01.017

PubMed ID: 27811232

Title: Mobility of 'HSPG-bound' LPL explains how LPL is able to reach GPIHBP1 on capillaries.

PubMed ID: 27811232

DOI: 10.1194/jlr.m072520

Sequence Information:

Length: 474
Mass: 53109
Checksum: E5895C98B7AE16CD
Sequence:

MESKALLLVV LGVWLQSLTA FRGGVAAADA GRDFSDIESK FALRTPEDTA EDTCHLIPGL 
ADSVSNCHFN HSSKTFVVIH GWTVTGMYES WVPKLVAALY KREPDSNVIV VDWLYRAQQH 
YPVSAGYTKL VGNDVARFIN WMEEEFNYPL DNVHLLGYSL GAHAAGVAGS LTNKKVNRIT 
GLDPAGPNFE YAEAPSRLSP DDADFVDVLH TFTRGSPGRS IGIQKPVGHV DIYPNGGTFQ 
PGCNIGEAIR VIAERGLGDV DQLVKCSHER SIHLFIDSLL NEENPSKAYR CNSKEAFEKG 
LCLSCRKNRC NNLGYEINKV RAKRSSKMYL KTRSQMPYKV FHYQVKIHFS GTEDGKQHNQ 
AFEISLYGTV AESENIPFTL PEVSTNKTYS FLIYTEVDIG ELLMMKLKWI SDSYFSWPDW 
WSSPSFVIER IRVKAGETQK KVIFCAREKV SHLQKGKDSA VFVKCHDKSL KKSG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lpl

Associated with

Other Information

Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution. PubMed ID: 2723548

The structure of the mouse lipoprotein lipase gene: a B1 repetitive element is inserted into the 3' untranslated region of the mRNA. PubMed ID: 1765386

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Adipogenesis in a myeloid supporting bone marrow stromal cell line. PubMed ID: 1339460

Cloning and characterization of the promoter of the murine lipoprotein lipase-encoding gene: structural and functional analysis. PubMed ID: 1748295

The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. PubMed ID: 3597382

Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. PubMed ID: 8675619

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. PubMed ID: 17403372

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. PubMed ID: 20620994

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. PubMed ID: 25066055

The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. PubMed ID: 24726386

Mobility of 'HSPG-bound' LPL explains how LPL is able to reach GPIHBP1 on capillaries. PubMed ID: 27811232