Details for: Zbtb7a

Gene ID: 16969

Symbol: Zbtb7a

Ensembl ID: ENSMUSG00000035011

Description: zinc finger and BTB domain containing 7a

Associated with

  • B cell differentiation
    (GO:0030183)
  • Cartilage development
    (GO:0051216)
  • Cell differentiation
    (GO:0030154)
  • Chromatin organization
    (GO:0006325)
  • Chromatin remodeling
    (GO:0006338)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-dependent protein kinase complex
    (GO:0070418)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Dna damage response
    (GO:0006974)
  • Dna repair
    (GO:0006281)
  • Double-strand break repair via classical nonhomologous end joining
    (GO:0097680)
  • Erythrocyte maturation
    (GO:0043249)
  • Fat cell differentiation
    (GO:0045444)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Nuclear androgen receptor binding
    (GO:0050681)
  • Nucleus
    (GO:0005634)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Protein binding
    (GO:0005515)
  • Protein localization to nucleus
    (GO:0034504)
  • Regulation of alternative mrna splicing, via spliceosome
    (GO:0000381)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of dna-binding transcription factor activity
    (GO:0051090)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of glycolytic process
    (GO:0006110)
  • Regulation of osteoclast differentiation
    (GO:0045670)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of transcription regulatory region dna binding
    (GO:2000677)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Site of double-strand break
    (GO:0035861)
  • Smad binding
    (GO:0046332)
  • Transcription corepressor binding
    (GO:0001222)

Other Information

Genular Protein ID: 3167587704

Symbol: ZBT7A_MOUSE

Name: N/A

UniProtKB Accession Codes:

O88939 B2RRP7 B7ZNL6 Q3U372 Q9CRJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 38 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 9927193

Title: Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene.

PubMed ID: 9927193

DOI: 10.1038/sj.onc.1202332

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14701838

Title: Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.

PubMed ID: 14701838

DOI: 10.1074/jbc.m310240200

PubMed ID: 15337766

Title: Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.

PubMed ID: 15337766

DOI: 10.1074/jbc.m405288200

PubMed ID: 15662416

Title: Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.

PubMed ID: 15662416

DOI: 10.1038/nature03203

PubMed ID: 17495164

Title: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

PubMed ID: 17495164

DOI: 10.1126/science.1140881

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26446488

Title: LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

PubMed ID: 26446488

DOI: 10.1038/ncomms9325

PubMed ID: 26816381

Title: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

PubMed ID: 26816381

DOI: 10.1126/science.aad3312

PubMed ID: 29813070

Title: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.

PubMed ID: 29813070

DOI: 10.1371/journal.pbio.2004526

Sequence Information:

  • Length: 569
  • Mass: 60281
  • Checksum: B4F79FF89A88CBD5
  • Sequence:
    • MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK 
KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS 
HVCADLLERQ ILAADDVGDA SQPDGAGPTD QRNLLRAKEY LEFFRSNPMN SLPPTAFPWS 
GFGAPDDDLD ATKEAVAAAV AAVAAGDCNG LDFYGPGPPA DRPPAGDGDE GDSTPGLWPE 
RDEDAPPGGL FPPPTAPPAT TQNGHYGRAG AGTGEEEAAA LSEAAPEPGD SPGFLSGAAE 
GEDGDAADVD GLAASTLLQQ MMSSVGRAGD SDEESRTDDK GVMDYYLKYF SGAHEGDVYP 
AWSQKGEKKI RAKAFQKCPI CEKVIQGAGK LPRHIRTHTG EKPYECNICK VRFTRQDKLK 
VHMRKHTGEK PYLCQQCGAA FAHNYDLKNH MRVHTGLRPY QCDSCCKTFV RSDHLHRHLK 
KDGCNGVPSR RGRKPRVRGV PPDVPAGAGA PPGLPDAPRN GQEKHFKDEE EDEEEASPDG 
SGRLNVAGSG GDDGAGGPAV ATAEGNFAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.