Genular: Defining Cellular Identity and Function

Details for: Lrp5

Gene ID: 16973

Symbol: Lrp5

Ensembl ID: ENSMUSG00000024913

Description: low density lipoprotein receptor-related protein 5

Associated with

Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Negative regulation of tcf-dependent signaling by wnt ligand antagonists
(R-MMU-3772470)
Regulation of fzd by ubiquitination
(R-MMU-4641263)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Adipose tissue development
(GO:0060612)
Amino acid transport
(GO:0006865)
Anatomical structure regression
(GO:0060033)
Anterior/posterior pattern specification
(GO:0009952)
Apoptotic process involved in blood vessel morphogenesis
(GO:1902262)
Blood vessel morphogenesis
(GO:0048514)
Bone development
(GO:0060348)
Bone marrow development
(GO:0048539)
Bone morphogenesis
(GO:0060349)
Bone remodeling
(GO:0046849)
Branching involved in mammary gland duct morphogenesis
(GO:0060444)
Canonical wnt signaling pathway
(GO:0060070)
Cell-cell adhesion
(GO:0098609)
Cell-cell signaling involved in mammary gland development
(GO:0060764)
Cell migration involved in gastrulation
(GO:0042074)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Coreceptor activity
(GO:0015026)
Embryonic digit morphogenesis
(GO:0042733)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Establishment of blood-brain barrier
(GO:0060856)
Establishment of blood-retinal barrier
(GO:1990963)
Extracellular matrix-cell signaling
(GO:0035426)
Gastrulation with mouth forming second
(GO:0001702)
Gene expression
(GO:0010467)
Limb morphogenesis
(GO:0035108)
Mammary gland duct morphogenesis
(GO:0060603)
Membrane
(GO:0016020)
Mesodermal cell migration
(GO:0008078)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Norrin signaling pathway
(GO:0110135)
Osteoblast development
(GO:0002076)
Osteoblast proliferation
(GO:0033687)
Plasma membrane
(GO:0005886)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering
(GO:1904395)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of apoptotic process
(GO:0042981)
Regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061178)
Retinal blood vessel morphogenesis
(GO:0061304)
Retina vasculature development in camera-type eye
(GO:0061298)
Retina vasculature morphogenesis in camera-type eye
(GO:0061299)
Somatic stem cell population maintenance
(GO:0035019)
Vasculature development
(GO:0001944)
Wnt-protein binding
(GO:0017147)
Wnt receptor activity
(GO:0042813)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

LRP5_MOUSE

Genular Protein ID: 870617520

Symbol: LRP5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q91VN0 E9QQ75 O88883 Q9R208

Database IDs:

Citations:

PubMed ID: 9714764

Title: Cloning of a novel member of the low-density lipoprotein receptor family.

PubMed ID: 9714764

DOI: 10.1016/s0378-1119(98)00311-4

PubMed ID: 10049586

Title: Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human.

PubMed ID: 10049586

DOI: 10.1006/geno.1998.5688

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11719191

Title: LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

PubMed ID: 11719191

DOI: 10.1016/s0092-8674(01)00571-2

PubMed ID: 12581525

Title: Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.

PubMed ID: 12581525

DOI: 10.1016/s0092-8674(03)00045-x

PubMed ID: 15142971

Title: The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

PubMed ID: 15142971

DOI: 10.1242/dev.01137

PubMed ID: 11956231

Title: Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor.

PubMed ID: 11956231

DOI: 10.1083/jcb.200201089

Sequence Information:

Length: 1614
Mass: 178885
Checksum: 80FF4288470A4FC5
Sequence:

METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV KLESTIVASG 
LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN IVISGLVSPD GLACDWVGKK 
LYWTDSETNR IEVANLNGTS RKVLFWQDLD QPRAIALDPA HGYMYWTDWG EAPRIERAGM 
DGSTRKIIVD SDIYWPNGLT IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF 
ALTLSGDTLY WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE 
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD LRRISLDTPD 
FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY LDGSGAQTLV NTEINDPDGI 
AVDWVARNLY WTDTGTDRIE VTRLNGTSRK ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN 
PKIECANLDG RDRHVLVNTS LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL 
EDKLPHIFGF TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG 
TNPCADGNGG CSHLCFFTPR ATKCGCPIGL ELLSDMKTCI IPEAFLVFTS RATIHRISLE 
TNNNDVAIPL TGVKEASALD FDVSNNHIYW TDVSLKTISR AFMNGSSVEH VIEFGLDYPE 
GMAVDWMGKN LYWADTGTNR IEVARLDGQF RQVLVWRDLD NPRSLALDPT KGYIYWTEWG 
GKPRIVRAFM DGTNCMTLVD KVGRANDLTI DYADQRLYWT DLDTNMIESS NMLGQERMVI 
ADDLPYPFGL TQYSDYIYWT DWNLHSIERA DKTSGRNRTL IQGHLDFVMD ILVFHSSRQD 
GLNDCVHSNG QCGQLCLAIP GGHRCGCASH YTLDPSSRNC SPPSTFLLFS QKFAISRMIP 
DDQLSPDLVL PLHGLRNVKA INYDPLDKFI YWVDGRQNIK RAKDDGTQPS MLTSPSQSLS 
PDRQPHDLSI DIYSRTLFWT CEATNTINVH RLDGDAMGVV LRGDRDKPRA IAVNAERGYM 
YFTNMQDHAA KIERASLDGT EREVLFTTGL IRPVALVVDN ALGKLFWVDA DLKRIESCDL 
SGANRLTLED ANIVQPVGLT VLGRHLYWID RQQQMIERVE KTTGDKRTRV QGRVTHLTGI 
HAVEEVSLEE FSAHPCARDN GGCSHICIAK GDGTPRCSCP VHLVLLQNLL TCGEPPTCSP 
DQFACTTGEI DCIPGAWRCD GFPECADQSD EEGCPVCSAS QFPCARGQCV DLRLRCDGEA 
DCQDRSDEAN CDAVCLPNQF RCTSGQCVLI KQQCDSFPDC ADGSDELMCE INKPPSDDIP 
AHSSAIGPVI GIILSLFVMG GVYFVCQRVM CQRYTGASGP FPHEYVGGAP HVPLNFIAPG 
GSQHGPFPGI PCSKSVMSSM SLVGGRGSVP LYDRNHVTGA SSSSSSSTKA TLYPPILNPP 
PSPATDPSLY NVDVFYSSGI PATARPYRPY VIRGMAPPTT PCSTDVCDSD YSTSRWKSSK 
YYLDLNSDSD PYPPPPTPHS QYLSAEDSCP PSPGTERSYC HLFPPPPSPC TDSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lrp5

Associated with

Other Information

Cloning of a novel member of the low-density lipoprotein receptor family. PubMed ID: 9714764

Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human. PubMed ID: 10049586

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. PubMed ID: 11719191

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. PubMed ID: 12581525

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. PubMed ID: 15142971

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. PubMed ID: 11956231